Scientist, physician, husband, father of daughters. I study and treat pulmonary hypertension. @willoldham@med-mastodon.com
Boston, MA
Joined August 2018
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Will Oldham retweeted
First preprint from the lab, led by @rantinggev!
We identify a metabolic bottleneck that helps set the pace of human development: low levels of the redox enzyme GPD1L limit NADH recycling. Boosting GPD1L mimics mouse cells and accelerates development!
biorxiv.org/content/10.64898…
Will Oldham retweeted
🫁🔬 Great work from @wm_oldham @BrownUnivHealth Pulm/CC/Sleep) — new in @ScienceTM identifying MCT1/MCT4 as promising targets for pulmonary fibrosis, cutting fibrotic damage in human cells & mouse models. 👏 tinyurl.com/OldhamBrown
@ATS_PC @PVRI @PHAssociation
Will Oldham retweeted
Spotlight: The first to establish alanine metabolism as a potential therapeutic target for fibrotic diseases👇
doi.org/10.1172/jci.insight.…
William M. Oldham @wm_oldham & team @BrownMedicine report scar-forming cells in #PulmonaryFibrosis rely on alanine as a metabolic building block and simultaneously blocking its synthesis and uptake suppresses #fibrosis in human lung tissue.
The images: Markers of myofibroblast differentiation (α-SMA and COL1A1) in IPF patient-derived cells under conditions of TGF-β stimulation (1/2) and impaired alanine metabolism (2/2).
with @EdyKim5
Will Oldham retweeted
Two for Thursday: We want to highlight another fantastic collaboration, this time with William Oldham's lab at Brown University and our @N8Krah, demonstrating that MCT4 is a druggable target in pulmonary fibrosis. Check it out here: science.org/doi/10.1126/scit… @UofUHematology @huntsmancancer
Congrats to everyone involved!
Will Oldham retweeted
Today marks the start of Brad Maron’s two-year term as PVRI President.
As Brad begins his presidency at this milestone moment for our community, his focus over the next two years will centre on:
▪️ Supporting career development across all stages
▪️ Strengthening equity and inclusion across global PH care
▪️ Expanding multidisciplinary collaboration, including AI, data science, and emerging research methods
▪️ Ensuring sustainable growth and transparency, while protecting access for early-career and global members
▪️ Addressing emerging global challenges shaping the future of PH
We’re grateful for Brad’s leadership and look forward to working together to advance research, care, and collaboration for our global PH community.
#PVRI2026
Will Oldham retweeted
Such well deserved recognitions all around! Delighted to see @BrownPVD’s @wm_oldham recognized along with Katarina Zeder for their invaluable contributions to making @PVRI a place where we all feel welcome and are excited to be every year!
Last night was about celebration and recognition ✨🏆️
The PVRI 2026 Gala Dinner honoured outstanding contributions across PH research, mentorship, and service — a powerful reminder of how far we’ve come together as a community.
Congratulations to our 2026 award recipients:
▪️Stephen Archer — PVRI Lifetime Achievement Award
▪️Daniel Colon Hidalgo — Butrous Foundation Young Investigator Award
▪️Sebastien Bonnet & Steeve Provencher — PVRI Achievement Award
▪️Gabor Kovacs — PVRI Achievement Award
▪️Katarina Zeder — PVRI Special Recognition Award
▪️Will Oldham — PVRI Special Recognition Award
▪️Abdullah Aldalaan — PVRI Special Recognition Award
▪️Sylvia Nikkho — Certificate of Recognition
Go raibh míle maith agaibh to all our awardees — and to everyone who makes the global PH community so special 👏
Will Oldham retweeted
Last night was about celebration and recognition ✨🏆️
The PVRI 2026 Gala Dinner honoured outstanding contributions across PH research, mentorship, and service — a powerful reminder of how far we’ve come together as a community.
Congratulations to our 2026 award recipients:
▪️Stephen Archer — PVRI Lifetime Achievement Award
▪️Daniel Colon Hidalgo — Butrous Foundation Young Investigator Award
▪️Sebastien Bonnet & Steeve Provencher — PVRI Achievement Award
▪️Gabor Kovacs — PVRI Achievement Award
▪️Katarina Zeder — PVRI Special Recognition Award
▪️Will Oldham — PVRI Special Recognition Award
▪️Abdullah Aldalaan — PVRI Special Recognition Award
▪️Sylvia Nikkho — Certificate of Recognition
Go raibh míle maith agaibh to all our awardees — and to everyone who makes the global PH community so special 👏
Will Oldham retweeted
#PVRI2026 was incredible! Got to catch up with friends & colleagues, hear exciting science, share our own (using PAEC biopsies & systems pharmacology for precision PAH care) and applaud @BrownPVD colleagues @wm_oldham & Dr. Klinger who were recognized for their own stellar work!
Will Oldham retweeted
Super excited to share that my first first-author story is live on BioRxiv! Huge thank you to @ishahjain, Ken Nakamura, + team at @GladstoneInst, @arcinstitute, @UCSF and beyond for their immense efforts on this project. 🧵
biorxiv.org/content/10.64898…
Will Oldham retweeted
Why do some genetic mutations devastate specific tissues while sparing others?
We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain.
🧵 on our new paper in Science:
🔗 science.org/doi/10.1126/scie…
Will Oldham retweeted
STING and PH? Check it out!
"Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension" by @ajbryantlab & team
insight.jci.org/articles/vie…
Will Oldham retweeted
Ever wonder how smooth muscle and inflammatory cells act through a common mediator in causing pulmonary hypertension? STING may be the answer.
JCI Insight - Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension insight.jci.org/articles/vie…
Will Oldham retweeted
Yesterday I was so thrilled to support my first mentee - the talented Talia Volpicelli, an MS-1 in the @BrownMedicine Basic and Translational Science Program. She presented our work on MYDGF at the DOM Research Symposium. I’m so excited to see all the great work she produces!
Will Oldham retweeted
Editorial Focus by @navneetsinghmd and @wm_oldham: Targeting type-2 inflammation in pulmonary hypertension: lessons from a novel model
ow.ly/sTqF50VEL4p. Read the original article at ow.ly/jRrT50VEL4r.
Will Oldham retweeted
Incredibly honored to see our work featured in the New England Journal of Medicine. Grateful to an outstanding team and collaborators who made this possible. A milestone we’ll never forget. #NEJM @MGBResearchNews @harvardmed @harvard_data @NUnetsi
Food contains more than 139,000 molecules, which influence nearly half the human proteome. Systematic analysis of food–chemical interactions can potentially advance nutrition science and drug discovery.
Learn more in the Review Article “Chemical Complexity of Food and Implications for Therapeutics,” the latest in the Nutrition in Medicine series, by Giulia Menichetti, PhD (@menicgiulia), Albert-László Barabási, PhD (@barabasi), and Joseph Loscalzo, MD, PhD, from @BrighamWomens, @harvardmed, @Northeastern, @Harvard, and @ceu: nej.md/3EEDtq4
ALT Nutrition in Medicine Chemical Complexity of Food and Implications for Therapeutics An illustrated table of the overall approach to food molecule research, from Nutrition Dark Matter (NDM) to Food as Medicine.
Will Oldham retweeted
Finally! The Pulmonary Fibrosis Drug Connectome is on #IPFCellAtlas!! If you want to know if a drug is antifibrotic, which cells it targets, or what drugs target a gene , in what cells - go to ipfcellatlas.com/ click on the Connectome tab. Enjoy!!
#DataSharing
#CurePF4All
Excited to announce that, In 26 days, I will be joining Brown University Health! Excited for new colleagues, new opportunities, and renewed energy to advance our work toward a cure for pulmonary fibrosis! @BrownPVD
Will Oldham retweeted
Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spec-based flux analysis framework to build a whole-body flux model of energy metabolism. Full article access here: authors.elsevier.com/a/1keM5…
@yuanbogeneral
Beautiful work! Congratulations! #cureIPF
It’s my pleasure to announce our recent work published in Nature Genetics: “Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis” 1/14 nature.com/articles/s41588-0…
Will Oldham retweeted
Hot off the printing press!! #pvri2025 delegate bags are ready. With only 2 weeks to go, we can’t wait to see you all in Rio soon! #pulmonaryhypertension
