Microbe-host crosstalk, engineering microbial therapies. Assistant Prof @MITBiology / Core Faculty @broadinstitute / Dermatologist MGH / HHMI Hanna Gray Fellow.
Joined April 2011
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Thank you @DamonRunyon so much for your support! I'm in such good company and excited to see what everyone will discover.
Congratulations to the recipients of the 2025 Damon Runyon-Rachleff Innovation Award! Five exceptional scientists received initial grants, and three previous awardees were given Stage 2 support to continue their critical work. Read more: damonrunyon.org/news/entries…
Beautiful work with @DjenetBousbaine @kdbauman_ @mfgrp @BelkaidLab - skin commensal colonization generates re-directable and potent antibody responses!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
I'm going to the other place, hope to meet again there! bsky.app/profile/yerinchen.b…
Totally agree - one of the most fun parts of doing science.
❤️
It’s always an amazing experience when reconnecting with my 2018 cohort of @HHMINEWS Hanna Gray Fellows! 6 years ago, we came to Headquarters and competed for this fellowship. This week, we’ve returned to our annual HGF retreat as Faculty Fellows! This community is priceless.!
Congrats Sam on this cool high resolution live cell imaging technology! Really setting the bar for super efficient junior faculty :)
Excited to share the first paper from the lab! pubs.acs.org/doi/full/10.102…
Limited by photobleaching in single-molecule imaging? We present multicolor long-term single-particle tracking in live cells for 10 min. The probes are actually stable for more than several hours!
Y. Erin Chen, MD PhD retweeted
Here is an open link to: Basic Science is not just a Foundation. (Nature Cell Biology, Volume 26, pages 8–10 (2024): rdcu.be/dv82R
We made the list! Work I did with @mfgrp @DjenetBousbaine. Much more to come on this advance from our labs.
Y. Erin Chen, MD PhD retweeted
Everyone has a best of list now that the year is coming to an end. I’m too disorganized to have a list but if I had one this paper would be right on top of it. – at Shoreline, WA
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. @yerinchen led the charge w/ help from @DjenetBousbaine, @VeinbachsA, @BelkaidLab. @ScienceMagazine 1/26
science.org/doi/10.1126/scie…
Y. Erin Chen, MD PhD retweeted
✨#ImmuneDictionary✨is out today in @Nature!
Paper nature.com/articles/s41586-0…
Software immune-dictionary.org
We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/
ALT The Immune Dictionary is a large-scale compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines in vivo, a reference for understanding the complex immune system. The image lists the 86 cytokines, representing almost all major cytokines in the immune system, studied in the dictionary. For more information, see our Nature (2023) publication "Dictionary of immune responses to cytokines at single-cell resolution": https://www.nature.com/articles/s41586-023-06816-9
Y. Erin Chen, MD PhD retweeted
Are all skin TRM cells created equal? Beyond excited to share our new paper in @ScienceMagazine, where we show diverse CD8+ TRM use distinct molecular pathways to develop and persist in skin, which we can target to fine-tune the skin-immune landscape🧵👇🏻 science.org/doi/10.1126/scie…
Y. Erin Chen, MD PhD retweeted
Check out @altaetran’s thread below for more info on our paper investigating rare CRISPR systems using big data approaches! Huge thank you to our team, collaborators and mentors Anthony, @KeplerMears, Esra, @lkmoeller, @kocalars, @rachel_oshiro, Kira, Rhiannon, Eugene and @zhangf
Our latest work exploring ultra rare CRISPR systems with new big data algorithms has been published by @ScienceMagazine! @zhangf @soumya_kannan12. This thread will unwrap how we found needles in a haystack of metagenomes. Let's dive in! (1/8) doi.org/10.1126/science.adi1…
There's still time to apply for this computational biology faculty position at MIT Biology!!! Deadline is Dec. 31, but send your application sooner rather than later. Looking for a creative and curious colleague to join our department!
Looking for a computational faculty to join my department - MIT Biology! It's a great place to work - apply here: academicjobsonline.org/ajo/j…
Learn about the cool biology and chemistry (at the single molecule level) happening in the lab next to us, led by super smart and nice @CTSPeng!
A great 2-minute video about our work. Thanks @broadinstitute for making me sound way more articulate and succinct than usual. :)
Meet Erin Chen, one of Broad's new core institute members. Hear from Chen, who joined the Broad early this year, about her lab's work studying how microbes on the skin communicate with the immune system. youtube.com/watch?v=YWCXYSxl…
Looking for a computational faculty to join my department - MIT Biology! It's a great place to work - apply here: academicjobsonline.org/ajo/j…
Y. Erin Chen, MD PhD retweeted
Are you a postdoc/grad student preparing to launch a faculty search? Have you worked to increase equity & inclusion in STEM? Apply to the 2023 Next Generation Faculty Symposium (berkeleystanfordnextgensympo…)! RT widely! (1/4) @CZBiohub @Stanford_ChEMH @StanfordBioE @StanfordBioX
Y. Erin Chen, MD PhD retweeted
Faculty Search(es) in Microbial Pathogenesis at Yale!
Come be our colleague! @YaleMicroPath is offering assistant professor faculty position(s) in pathogenesis of viral/bacterial/parasitic infections, pathogen-host interactions, and microbes in health and disease. Info: apply.interfolio.com/129541. Q&A webinar in Sept. Please RT!
