Scientist studying mucosal immunity and gut microbiota
St Louis, MO
Joined February 2021
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Excited to share that I’ve joined VCU as an Assistant Professor and launched the Fachi Lab! We study how diet, the gut microbiota, and tissue-derived signals shape mucosal immunity, dysbiosis, and susceptibility to intestinal diseases, especially C. difficile infection.
José Fachi, PhD retweeted
Excited to share our latest work in J Exp Med! We identify LINGO4 as a key regulator of ILC3 fitness, IL-22 production and microbiota homeostasis, with major impact on host defense against enteric infection. Check it out!
doi.org/10.1084/jem.20252632
José Fachi, PhD retweeted
Fachi, Trsan, Colonna et al. identify LINGO4 as a key regulator of ILC3s, coordinating mitochondrial fitness & IL-22 production. LINGO4 deficiency disrupts #ILC3 function & #microbiota composition, altering susceptibility to enteric infections hubs.la/Q04dLS_k0
José Fachi, PhD retweeted
LINGO4 is a key regulator of mitochondrial fitness and IL-22 production in ILC3, reducing susceptibility to enteric infections @JExpMed @TheColonnaLab @WashU @zefachi
rupress.org/jem/article/223/…
José Fachi, PhD retweeted
🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴
sciencedirect.com/science/ar…
José Fachi, PhD retweeted
Platelet-derived growth factor D (#PDGFD) binds to PDGFRβ in #ILC3s in mice and NKp44 in human ILC3s, promoting divergent innate immune responses following intestinal infections. @TheColonnaLab
Learn more in Science #Immunology: scim.ag/4aXJmL1
José Fachi, PhD retweeted
Excited to share our new work in @SciImmunology, led by @zefachi! Mesenchymal cells produce PDGF-D during colitis, driving species-specific ILC3 programs: via PDGFRβ in mice (IL-22, repair) and NKp44 in humans (type I response, pathogen clearance).
science.org/eprint/EFDJ3BJRF…
José Fachi, PhD retweeted
PDGF-D engages PDGFRβ in mice and NKp44 in humans to drive ILC3 responses @SciImmunology
science.org/doi/10.1126/scii… @TheColonnaLab @zefachi
José Fachi, PhD retweeted
Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses.
rb.gy/lyvce8
José Fachi, PhD retweeted
@zefachi talk is now on YouTube!
🎙️ José Luis Fachi (Washington University in St. Louis l)
📣 NKp46+ ILC3s promote early neutrophil defense against Clostridioides difficile infection through GM-CSF secretion (PNAS, 20254)
youtu.be/wEaptMNfNw0
José Fachi, PhD retweeted
Excited to share that our work by @PatFernRod and @TongWu99 is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more: authors.elsevier.com/sd/arti…
José Fachi, PhD retweeted
OBS #Immunology Seminar ILC3
📆 Thu, 27th March , 9 am PDT, 12 pm EDT
🎙️@zefachi@TheColonnaLab
🎙️ Leandro Pires Araújo -Ivaylo I. Ivanov Lab
📣 Moderator @eugeccc
Registration
us02web.zoom.us/meeting/regi…
José Fachi, PhD retweeted
Estudo sugere que consumo de #fibras protege o #intestino contra infecção bacteriana grave. Roedores alimentados com dieta rica em fibras solúveis lidaram melhor com microrganismo que causa diarreia e pode levar pacientes debilitados à morte. agencia.fapesp.br/54030
Excited to share that our work is featured on the cover of the latest issue of Cell Host & Microbe! Check it out! @TheColonnaLab @VinoloM @pewtrusts
#Microbiology #Immunology #CellHostMicrobe
Our February issue is now live. Come explore the depths of microbiology!
cell.com/cell-host-microbe/c…
José Fachi, PhD retweeted
Fiber fine tunes MHC to impact CDI
Low-fiber diet worsens C. difficile infection by increasing MHC-II in colonic epithelium, promoting pathogenic CD4+IELs. Acetate from fibers enhances ILC3-derived IL-22, suppressing MHC-II expression
@TheColonnaLab
cell.com/cell-host-microbe/f…
José Fachi, PhD retweeted
A study from @victora_lab and @danmucida in @ScienceMagazine reveals how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of both food allergies and intestinal diseases. #RockefellerScience bit.ly/4hyS18b
José Fachi, PhD retweeted
Our new paper in Cell Host & Microbe:
Low-fiber diets worsen C. difficile infection by increasing epithelial MHC-II and expanding pathogenic CD4+ IELs. Fiber-derived acetate and FFAR2 boost ILC3 IL-22, suppressing colonic MHC-II and aiding recovery.
authors.elsevier.com/sd/arti…
José Fachi, PhD retweeted
Our work by Fachi et al. @zefachi is out in PNAS! We show how NKp46+ ILC3s boost early gut defense against C. difficile infection by producing GM-CSF to support neutrophils. A potential path to new CDI treatments!
pnas.org/doi/10.1073/pnas.24…
José Fachi, PhD retweeted
.@Siyan_Cao et al. from the @TheColonnaLab @WUSTLmed show that the IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease: buff.ly/3W7heyJ
#Gastroenterology #Immunology
