
ALT This image is a set of figures showing PRAME-specific T cells in a pediatric patient with nephroblastoma. Panel A shows a schematic illustration of the mode of action of autologous T cells transduced with a vector encoding for both the HLA-A*02:01–restricted T-cell receptor (TCR) that is specific to preferentially expressed antigen in melanoma (PRAME) and the CD8αβ coreceptor. Panel B shows a schematic overview of the timing of the patient’s treatment course after the PRAME-specific TCR infusion. Panel C shows the patient’s radiologic response in a comparison of imaging performed before treatment and at 6 months. Panel D shows the change in the diameter of respective target lesions measured. Panel E shows the metabolic response on 18F-fluorodeoxyglucose positron-emission tomography–CT (FDG PET-CT) (transverse plane). Panel F shows the results of an analysis of cfDNA in peripheral blood, plotted as the fraction of circulating tumor DNA (ctDNA) within cfDNA.






























