@Abdul_Squared

@TriIMDPhD @junyue_cao lab @RockefellerUniv @WeillCornell (views are my own) Previously @broadinstitute @RutgersU-B.A

 New York, NY
Joined March 2020
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  • Following816
  • Followers604
15Media
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…

Optics-free spatial genomics for mapping mammalian brain aging by IRISeq

Nature Neuroscience - The authors developed an optics-free spatial genomics method to map mouse brain aging, revealing region-specific inflammation and showing that lymphocytes promote harmful...

nature.com
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In our latest work, led by @schoenfeld_j, we explore one of the great enigmas of cancer biology: how systemic iron sequestration promotes tumor progression. 🧵 biorxiv.org/content/10.64898…

Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer

Systemic iron sequestration occurs frequently in cancer due to inflammation-driven expression of the iron-regulatory hormone hepcidin. The impact of systemic iron availability on tumoral immunity is...

biorxiv.org
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Eric Topol
@EricTopolOct 14
Brown fat declines with age but its persistence in adults is linked to less cardiovascular disease, Type 2 diabetes, and hypertension. A new study @Nature using AI in 100,000 people to quantify brown fat adds reduced depression and much more to the list of associated benefits. And commonly used blood pressure medications—angiotensin receptor blockers (ARBs)— increase brown fat prevalence nature.com/articles/s41586-0… nature.com/articles/d41586-0…
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Incredibly excited to share our paper out today in @Nature! We developed a systems-based approach to deeply characterize brown fat in humans and identify medications that could be repurposed to activate this tissue. Immensely grateful to everyone involved nature.com/articles/s41586-0…

Artificial intelligence-enabled clinical phenotyping of human brown fat

Nature - Artificial intelligence-enabled quantification and analyses of brown adipose tissue (BAT) activity uncover links between BAT and a healthier metabolic profile along with lower rates of...

nature.com
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Check out our Opinion paper in @Nature, where we write about: i) The decline in physician-scientist numbers worldwide ii) Why this might be, based on our own data and others’ iii) Steps to reverse the decline nature.com/articles/d41586-0… @rezamotallebov @CharlesSwanton @bealelab

Keep medical doctors in academia — without them, health-care research will suffer

Nature - Better career support and more funding stability is needed to retain this invaluable group of scientists.

nature.com
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Supratim Datta@taurine__Oct 5
The landmark @NatureNeuro paper where @KarlDeisseroth and coworkers showed that a light-sensitive algal protein, Channelrhodopsin-2 (ChR2), could be genetically expressed in mammalian neurons and used to trigger action potentials with millisecond precision. @NobelPrize
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The Nobel Prize
@NobelPrizeOct 5
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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The Nobel Prize
@NobelPrizeOct 5
WATCH LIVE: Join us for the announcement of the 2026 Nobel Prize in Physiology or Medicine. Hear the breaking news first. Where are you watching from? #NobelPrize xitter.cf/i/broadcasts/1RKZzBOPj…
0:00

The Nobel Prize

Announcement of the 2026 Nobel Prize in Physiology or Medicine

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NEJM
@NEJMSep 30
Clinical Implications of Basic Research: The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond nej.md/4A71sWP #Neurology #SleepMedicine
An illustrated diagram from the Clinical Implications of Basic Research article "The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond." Panel A shows the orexin system, discovered in 1998, which consists of two neuropeptides produced in the lateral hypothalamus and two G-protein–coupled receptors expressed in most areas of the brain. Panel B shows deficiency of orexin signaling leading to narcolepsy symptoms in both dogs and rodents. Panel C shows that human patients with narcolepsy lack orexin peptides in the cerebrospinal fluid (CSF), which has led to a reliable diagnostic test. Panel D shows therapeutics from 2014 to the Present.

ALT An illustrated diagram from the Clinical Implications of Basic Research article "The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond." Panel A shows the orexin system, discovered in 1998, which consists of two neuropeptides produced in the lateral hypothalamus and two G-protein–coupled receptors expressed in most areas of the brain. Panel B shows deficiency of orexin signaling leading to narcolepsy symptoms in both dogs and rodents. Panel C shows that human patients with narcolepsy lack orexin peptides in the cerebrospinal fluid (CSF), which has led to a reliable diagnostic test. Panel D shows therapeutics from 2014 to the Present.

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So excited to see my thesis work out in the world! Incredibly grateful to my co-first author Chhiring, @AnnaEnim, and the many people who contributed to this work and made it possible. So much went into this one 🎉
Anna Nam@AnnaEnimSep 15
How does interferon-alpha interfere with clonal evolution in human blood stem cells? We address it here @natureGenet: nature.com/articles/s41588-0… 🎉 Congrats to our super talented students Chhiring Lama, @danielle_isakov! Wonderful collab w/ Ron Hoffman. @WCMC, @WCMCPathology 🧵⤵

Type 1 interferon perturbates clonal competition by reshaping human blood development

Nature Genetics - Single-cell multiomics of blood stem cells from patients with myeloproliferative neoplasms revealed that interferon-α normalizes blood counts by augmenting lymphoid...

nature.com
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By deciphering the molecular signatures of millions of mouse cells, Rockefeller's @junyue_cao has found that aging is not haphazard wear and tear but rather a “remodeling of the cell society.” Learn more in this piece from @QuantaMagazine: bit.ly/4in9iVu

Why Aging May Be a Program, Not a Breakdown | Quanta Magazine

By deciphering the molecular signatures of millions of mouse cells, Junyue Cao has found that aging is not haphazard wear and tear but rather a “remodeling of the cell society.”

quantamagazine.org
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Junyue
@junyue_caoJul 23
Our paper is officially out in @NatureComms today rdcu.be/fvoEY Congrats to @xu_zxu and Aileen from the lab!
Junyue
@junyue_caoJun 3
New preprint alert! 🚀 Across 60 human cancer cell lines spanning 20 cancer types, single-cell RNA+ATAC reveals pan-cancer cell-state heterogeneity, core gene-regulatory networks, and an EMT axis conserved across tissue origins. Huge congrats to first author @xu_zxu, who recently defended his PhD, and Aileen Ugurbil from our lab @RockefellerUniv! biorxiv.org/cgi/content/shor…
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We are heartbroken to have lost our founder, who provided so much inspiration, but we are all honored to carry on the science he loved so much. picower.mit.edu/news/picower… #neuroscience #biology

Picower Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

Tonegawa made landmark discoveries about how the immune system generates antibody diversity and how the brain forms memories.

picower.mit.edu
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I couldn’t be prouder to announce that @tanmana_mitra’s thesis work identifying how metabolic demand drives terminal T cell exhaustion is out today in @ImmunityCP : authors.elsevier.com/a/1nQx9…
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Ruslan Rust
@rust_ruslanJun 30
Wow such cool work: A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates biorxiv.org/content/10.64898…
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Congrats @JasonSynaptic and team! Stunning and easy to understand results, which is becoming more rare these days in neuroscience.
Jason Shepherd@JasonSynapticJun 29
Very excited for our new paper, now out in @CellCellPress! /🧵The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms of Tau transmission are not clear. /1
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We’re happy to announce 2 releases today: - 🧠Brain2qwerty v1 is published at @NatureNeuro - 🚀 Brain2Qwerty v2 is now publicly released Explore how we decode sentences from non-invasive brain recordings: facebookresearch.github.io/b… Links: 📄v1 Nature Neuro: nature.com/articles/s41593-0… 📑v2 Meta preprint: facebookresearch.github.io/b… 💻Code: github.com/facebookresearch/… 📊Data: huggingface.co/datasets/bcbl… 📝Blog: ai.meta.com/blog/brain2qwert… 🧵Thread: xitter.cf/JarodLevy/status/20715…
Jarod Levy@JarodLevyJun 29
🧠⌨️ Decode language from brain activity without surgery. 🧠⌨️ Brain2Qwerty V1 is officially published in Nature Neuroscience. Today, we're releasing Brain2Qwerty V2. We achieve unprecedented performance for a non-invasive MEG setup. Details below 🧵👇
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Ro Khanna
@RoKhannaJun 22
GPS in 1980s, Human Genome Project, CRISPR at Berkley funded through NIH, mRNA, expanded and early Head Start...
Ethan Agarwal
@ethanagarwalJun 22
It’s telling that you can’t point to an example in the last 45 years where the government allocated capital better than the private sector.
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Josh Welch@LabWelchJun 12
Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. nature.com/articles/s41588-0…

CytoSignal detects locations and dynamics of ligand–receptor signaling at cellular resolution from...

Nature Genetics - CytoSignal models ligand–receptor interactions at cellular resolution using spatial transcriptomic data, inferring interaction scores at each spatial position and predicting...

nature.com
Josh Welch@LabWelch15 Mar 2024
How can you use RNA velocity to infer the dynamics of cell signaling from spatial transcriptomic data? Check out our new preprint!
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Sherif Gerges@SherifMorrisJun 8
I’m delighted to finally share work from my PhD with @dalygene and @s_mccarroll. We show how human genetics and AlphaFold3-predicted protein structure can be combined to discover new mechanisms underlying missense risk in brain disorders. 1/n biorxiv.org/content/10.1101/…

Genetic and structural evidence links Ca2+ dysregulation and ATP2B2 to neuropsychiatric illness

Neuropsychiatric disorders are highly heritable, but the molecular mechanisms linking risk variants to disease remain unclear[1][1]. Linking genetics to biological mechanisms requires integrating...

biorxiv.org
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Joshua Weinstein@jaweinstJun 4
Delighted to share our new preprint on xVDM (cross-linked volumetric DNA microscopy), turning the protein scaffolds inside intact tissue into dense, DNA-encoded proximity networks for transcriptome and protein mapping. biorxiv.org/content/10.64898…
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