Using whole-body cell-level imaging to improve disease understanding and therapy development.
Munich
Joined May 2022
- Tweets17
- Following109
- Followers861
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Deep Piction retweeted
An intact human heart, rendered transparent.
Because disease doesn't happen in 2D.
Whole-organ tissue clearing + microscopy reveal coronary vessels (magenta) and atherosclerotic plaques (gold) across the intact organ.
More at: shorturl.at/iqTBh
🫀🔬#FluorescenceFriday!
We're growing! 🔬🧠
Deep Piction is hiring a Scientist to work with tissue clearing, light-sheet microscopy, 3D image analysis, and AI-driven spatial biology.
You'll help generate and analyze some of the world's most detailed whole-organ datasets while contributing to next-generation therapeutics.
📍Munich, Germany
Details below 👇
#Hiring #Biotech #Microscopy #ImageAnalysis #SpatialBiology
We’re hiring at @DeepPiction 🧠🔬
We are looking for a Scientist – Tissue Clearing & Image Analysis (m/f/d) to join our team in Munich.
You will help drive tissue-clearing, light-sheet microscopy, and quantitative 3D imaging projects across internal R&D programs and collaborations with biotechnology and pharmaceutical partners. The role combines hands-on experimental work, project ownership, workflow development, and close collaboration with our AI and image-analysis teams.
We’re looking for someone with strong experience in tissue clearing, fluorescence microscopy, light-sheet imaging, and large-scale 3D image analysis.
Please apply with one single PDF containing your CV and cover letter to:
[email protected]
Subject: Scientist – Tissue Clearing & Image Analysis (DP-TC-2026-01)
Applications will be reviewed on a rolling basis until the position is filled.
linkedin.com/jobs/view/44366…
Deep Piction retweeted
Just out in Cell: a new imaging-based multimodal characterization (IMC) platform combines 𝗗𝗜𝗦𝗖𝗢 tissue clearing, whole-brain single-neuron reconstruction, spatial transcriptomics, and in vivo calcium imaging to profile the same neuron across function, morphology, and gene expression.
By integrating neuronal activity, brain-wide connectivity, and transcriptomic identity in individual neurons, the study provides a powerful framework to understand how genes, structure, and function come together to shape neural circuits.
Great work by the Shengjin Xu and Kai Wang labs!
cell.com/cell/fulltext/S0092…
Deep Piction retweeted
Biology was never meant to be studied in 2D.
One of the coolest things about my new work is being able to visualize:
🧠 Neural circuits
🩸 Vascular networks
🎯 Drug biodistribution
🎗️ Disease progression
Here's a small glimpse of what we're building at @DeepPiction🤩🔬
For decades, we've asked where therapeutics go in the body.
Now we can ask which cells they reach.
Our new SCP-Nano platform combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations.
A new way to accelerate the development of safer and more precise therapies. Read our paper published at @NatureBiotech nature.com/articles/s41587-0…
Deep Piction retweeted
Great to see @VirusesImmunity last paper highlighted at @NatRevImmunol. One of the strongest pieces of evidence yet for autoimmunity in #LongCOVID.
Not proof that autoimmunity explains all neurological Long COVID, but it's getting harder to dismiss as one important mechanism.
Deep Piction retweeted
Amazing work by the entire @DeepPiction team! Proud to see this level of spatial biology pushing boundaries with wildDISCO — whole-body immunolabeling that delivers cellular-resolution 3D atlases while preserving full anatomical context in situ. 🧠🔬
Spatial biology has the power to show us real insights exactly where they matter most.
At @neurosimplicity, we believe research teams should focus on biology and discovery, not data processing. That’s why we’ve built the Neurosimplicity Imaging Suite to automatically extract key insights and compare them against available or custom cohort atlases. More than that, though, the Imaging Suite is purposely built as a next-generation platform for seamless collaboration with terabyte-scale data.
This is exactly the kind of breakthrough that deserves frictionless analysis and sharing. Congrats on the Nature Protocools paper! 🚀
#SpatialBiology #TissueClearing #Imaging #wildDISCO
Deep Piction retweeted
We developed wildDISCO, a whole-body immunolabeling method that makes entire mice transparent and maps cells in 3D using standard antibodies.
We are now using this technology to develop powerful cell-level targeting therapeutics.
How do you map every cell in an entire mouse without slicing it into thousands of sections? Our recently published paper in @NatureProtocols describes wildDISCO: a whole-body immunolabeling approach that makes the mouse transparent and labels cells throughout the body using standard antibodies. The result? Cellular-resolution 3D atlases of entire organisms, preserving the anatomical context that is often lost in traditional histology.
Check more at: nature.com/articles/s41596-0…
#SpatialBiology #Imaging #TissueClearing
Deep Piction retweeted
We are working with Roger Luo who is now @LifeAtPurdue to visually map polyorganic sensory neurons. This work is absolutely powerhouse in terms of the technology!
How do you map every cell in an entire mouse without slicing it into thousands of sections? Our recently published paper in @NatureProtocols describes wildDISCO: a whole-body immunolabeling approach that makes the mouse transparent and labels cells throughout the body using standard antibodies. The result? Cellular-resolution 3D atlases of entire organisms, preserving the anatomical context that is often lost in traditional histology.
Check more at: nature.com/articles/s41596-0…
#SpatialBiology #Imaging #TissueClearing
🚀 Meet Deep Piction at #BIOCAP26 in Berlin this week (June 9–11)!
The biggest challenge in drug delivery isn't getting a payload into the body, it's knowing where it actually ends up.
Our platform maps therapeutic biodistribution across entire organs at single-cell resolution, providing insights that conventional approaches miss.
Stop by Booth 8B and chat with our Head of nanotechnology & drug delivery, @cerenkimna, about how we're accelerating the development of in vivo therapies for different diseases.
#Biotech #DrugDevelopment #GeneTherapy #CellTherapy #PrecisionMedicine
How do you map every cell in an entire mouse without slicing it into thousands of sections? Our recently published paper in @NatureProtocols describes wildDISCO: a whole-body immunolabeling approach that makes the mouse transparent and labels cells throughout the body using standard antibodies. The result? Cellular-resolution 3D atlases of entire organisms, preserving the anatomical context that is often lost in traditional histology.
Check more at: nature.com/articles/s41596-0…
#SpatialBiology #Imaging #TissueClearing
Deep Piction retweeted
Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend @HarsharanBhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys. biorxiv.org/content/10.64898…
We are excited to share our recent study describing
DISCO-seq, a new technique that combines RNA-preserving tissue clearing with whole-organ 3D imaging to enable unbiased single-cell transcriptomics. Read here: biorxiv.org/content/10.64898…
Single-cell RNA-seq transformed biology, but we still sample <0.001% of an organism.
2D sections lose 3D context.
What if we image the whole body first?
We Introduce DISCO-seq🤩: full 3D imaging then scRNAseq👇🏻biorxiv.org/content/10.64898…
by @HarsharanBhatia, Laurent Simons et al.
Deep Piction retweeted
From Whole Body to Single Cell. At DeepPiction.com we
can see where disease begins and identify ways to make therapies safer & more effective. We’re excited to share our new paper at @Nature! Our goal is to advance drug discovery for #Cancer, #LongCovid & #Inflammation
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level
go.nature.com/4dD02sq
Deep Piction retweeted
If you missed the video for our recent @Nature study, check it out 👇🏼 Turn on the sound! We added some art to it 😊
Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733
Deep Piction retweeted
Cure ME/CFS and long COVID.
Tens of millions of people are lying in dark rooms right now, waiting for someone to crack a biology that medicine still barely understands.
With the right data, if AI can decode the mitochondrial dysfunction, the immune dysregulation, the broken energy metabolism, the autonomic collapse, it will have done something no institution has bothered to fund properly in years.
That would be historic.
Please save us.
From Whole Body to Single Cell. At DeepPiction.com we
can see where disease begins and identify ways to make therapies safer & more effective. We’re excited to share our new paper at @Nature! Our goal is to advance drug discovery for #Cancer, #LongCovid & #Inflammation
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level
go.nature.com/4dD02sq