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Pan Mass Challenge #PMC2024 Day 2 riding to the Provincetown at the tip of Outer Cape Cod. Thanks to #PaulsPosse Team and so many other for support of #sarcoma and #GIST research @DanaFarber
george demetri retweeted
The line of the week in biotech comes from Roivant CEO @gline during #statsummit. He also appears to be throwing some shade at the debate in the AI community about AI consciousness, a topic that has also raised safety concerns. $ROIV $XBI $IBB
george demetri retweeted
The Trump attack on science has throttled the NIH and continues to threaten the NCI's cancer research. Fred Hutch biostatistician Joe Unger and team have dissected how NCI-funded work is fundamentally different from what pharma does, going after rare cancers, pediatric work, dosing, combinations, multi-modality studies. All the things that pharma won’t touch because there’s no money in it. I think it’s time for all of us to do the right thing here, and push for a much larger commitment to the NCI. Biopharma benefits from more early research and patients benefit from longer, better quality lives. Here’s what I’m talking about:
endpoints.news/as-trump-2-0-…
george demetri retweeted
Ex Pfizer R&D president @John_LaMattina, who spent 30 yrs at the company incl two mega-mergers, responded on LinkedIn to the AZ/BMS news: "Both R&D organizations will be in turmoil for at least 18 months. Look at their current clinical timelines & add a year... What a disaster."
AstraZeneca holds talks with Bristol Myers Squibb over $400bn tie-up giftarticle.ft.com/giftartic… via @financialtimes
george demetri retweeted
Mega mergers are bad for biotech M&A.
If this $AZN $BMY deal happens, it’s because they believed the best way forward was doing something that history has proven never really works out. They prefer “cost synergies” over buying your favorite biotech.
There are other buyers out there, of course, but make no mistake, a mega- deal like this one dents the biotech M&A thesis.
I guess you can hope this rumor is just a trial balloon and AZ shareholders revolt.
george demetri retweeted
Amazing comments from Elias Zerhouni… thanks for speaking out, Elias!
𝐔.𝐒. 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐒𝐮𝐦𝐦𝐢𝐭: @ModeXTx Founder and Former NIH Director Elias Zerhouni shares his thoughts on a recent OMB proposal to add a political decision making element to the grant making process.
george demetri retweeted
In 1948, Sidney Farber and colleagues published his work in @NEJM that helped open the door to modern chemotherapy.
Seeing that history from the same institution — especially after a remarkable #ASCO26 with major plenary contributions and @NEJM papers from @DanaFarber — is humbling.
A powerful reminder that progress in oncology is built across generations: by patients, scientists, clinicians, and teams who keep asking what might be possible.
Wise words of optimism and vision from a true visionary who has been right most of the time. We all got through the 1960’s and early 70’s that also divided the country in seemingly terminal ways, but this remarkable country continues to mature, to grow, and to thrive.
America at 250. Amazing. Flawed. Amazing. Founded by risk takers and religious extremists. For the young, watch the people from everywhere in the World marveling at our Freedom, the Beauty. The Openness. The Freedom to speak. To Protest. To fly the Flag. Even the Unity. Maybe you actually do not understand what you have.
Those on the far left that want to take it away and far right intolerance will lose. We defeated kings. We are one of the two civilizations in History to END slavery that was practiced by all nations of every creed and color for thousands of years. We saved the world from tyranny. Twice. Won the cold war, defeated the idiocy of socialism and communism.
We are the only country where the children of immigrants will out earn the average. Our innovation has fueled the world. Brought billions out of poverty. Ignited the age of information and AI. The great nations copy us-Imitation is the best form of flattery.
We are ALL the children and grandchildren of immigrants. We will survive governments you hate, and you forget that governments in USA matter far less that a free people, in a beautiful, bountiful land, where we are imperfect for sure, but good hearted.
We need to reject the hatred and division spewed on the left and intolerance on the right and amplified by social media. 80 percent of the country is just fine. Building families, searching for opportunity, defending the weak. Standing up in a complicated and messy world. 250 years of vision. Many years left. So many count us out, and we survive and thrive and lead.
george demetri retweeted
Legendary pharma industry commentator Derek Lowe says "the Trump administration is trying to destroy federally-funded research in the US as we know it and replace it with cronyism and worse."
And who's not speaking up about it? The CEOs of major biopharma companies.
Lowe calls this "odd," apparently using the word the same way I do. (It translates to "batshit crazy.")
He points out:
"(1) the great majority of the employees at these companies came through that exact funding system at some point in their careers, and (2) since the industry depends on the basic science research funded this way to make its own advances in applied and clinical applications."
He has an explanation, though. He thinks they're all scared.
science.org/content/blog-pos…
george demetri retweeted
Congrats to ARCH investment Parabilis (PBLS) and the leadership of Mathai Mammen and innovation of Greg Verdine for its’ record IPO. And thank you to the inspiration of Rick Klausner. Fuck Cancer.
george demetri retweeted
The mob crushing into the #ASCO26 plenary. Like a Who concert in 1979.
george demetri retweeted
a standing ovation for daraxonrasib at asco. over 40k oncologists, entrepreneurs, investors, and patient advocates together celebrating revmed's breakthru in the fight against pancreatic cancer. u never forget these moments. it's what innovation is all about.
george demetri retweeted
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
george demetri retweeted
In the latest issue! Hallmarks of cancer—Then and now, and beyond dlvr.it/TS4Plc
george demetri retweeted
This paper from Harvard and MIT quietly answers the most important AI question nobody benchmarks properly:
Can LLMs actually discover science, or are they just good at talking about it?
The paper is called “Evaluating Large Language Models in Scientific Discovery”, and instead of asking models trivia questions, it tests something much harder:
Can models form hypotheses, design experiments, interpret results, and update beliefs like real scientists?
Here’s what the authors did differently 👇
• They evaluate LLMs across the full discovery loop hypothesis → experiment → observation → revision
• Tasks span biology, chemistry, and physics, not toy puzzles
• Models must work with incomplete data, noisy results, and false leads
• Success is measured by scientific progress, not fluency or confidence
What they found is sobering.
LLMs are decent at suggesting hypotheses, but brittle at everything that follows.
✓ They overfit to surface patterns
✓ They struggle to abandon bad hypotheses even when evidence contradicts them
✓ They confuse correlation for causation
✓ They hallucinate explanations when experiments fail
✓ They optimize for plausibility, not truth
Most striking result:
`High benchmark scores do not correlate with scientific discovery ability.`
Some top models that dominate standard reasoning tests completely fail when forced to run iterative experiments and update theories.
Why this matters:
Real science is not one-shot reasoning.
It’s feedback, failure, revision, and restraint.
LLMs today:
• Talk like scientists
• Write like scientists
• But don’t think like scientists yet
The paper’s core takeaway:
Scientific intelligence is not language intelligence.
It requires memory, hypothesis tracking, causal reasoning, and the ability to say “I was wrong.”
Until models can reliably do that, claims about “AI scientists” are mostly premature.
This paper doesn’t hype AI. It defines the gap we still need to close.
And that’s exactly why it’s important.
george demetri retweeted
Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers | Nature nature.com/articles/s41586-0…
george demetri retweeted
Hope to see you there if you are at #AACR2026 @CancerGrand. Add it to your programme Mon 20th Apr, 5pm - Room 11, Upper Level, San Diego Convention Center.
Heading to #AACR? Don’t miss this first-of-its-kind session exploring breakthrough discoveries from Cancer Grand Challenges.
🔊Chair: @CharlesSwanton | Speakers: @balma85185, @EileenWhitePhD, Karen Cichowski (@CichowskiLab) and Mike Stratton
💡Representing teams: PROMINENT, Mutographs, SPECIFICANCER and CANCAN
📅 Monday 20 April, 5pm PT at @AACR
📌 Room 11 - Upper Level
Add this to your #AACR26 itinerary: abstractsonline.com/pp8/#!/2…
@CR_UK, @theNCI, @UCSF. @RutgersCancer, @harvardmed, @sangerinstitute, @TheCrick
george demetri retweeted
Scientific publishing needs to change. In a new preprint, HHMI President Erin O'Shea and Bodo Stern argue that the incentives are misaligned. Researchers should be evaluated on what they choose to share, not what journals select. I’m proud that @hhmi_science is leading the way. Read the preprint here: doi.org/10.5281/zenodo.19600…
george demetri retweeted
How Do Cancer Cells ‘Learn’ to Resist Treatment?
nyulangone.org/news/how-do-c…
Congratulations to @ItaiYanai @nyulangone for his elegant @Nature paper today that made the cover!
nature.com/articles/s41586-0…
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