neuron-glial interactions, oligodendrocyte lineage, myelin, multi-photon microscopy @CUMedicalSchool
Denver, CO USA
Joined October 2018
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Ethan Hughes retweeted
Repair after CNS injury is not strictly local!
We find that lesion-remote astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter.
@Nature
bit.ly/3KNUm4D
Ethan Hughes retweeted
Glad to share our published version: “ Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms”, led by @AksheevB
nature.com/articles/s41593-0…
Ethan Hughes retweeted
Driving CNS myelination with an approved drug. Fantastic collaboration with Hannelore Ehrenreich and her team at @mpi_nat nature.com/articles/s41467-0…
Ethan Hughes retweeted
Excited to introduce four new mouse lines described in our recent study @YiheZhang97 (soon available from JAX), including two lines for studying TFEB in broader contexts (TFEB 6xMyc, JAX#041044; Rosa26-TFEBS141A;S210A-Halo, JAX#041043) and two new KI lines for myelinating OLs.
Ethan Hughes retweeted
1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint.
If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too below.
biorxiv.org/content/10.1101/…
Ethan Hughes retweeted
You can support the next generation of myelin scientists by funding the Myelin Gordon Research Seminar: my.grc.org/p/contributions/1…. @ubhjkri @MS_Focus @mssociety @NeuroForuMS @SfNtweets @GlialInitiative
Ethan Hughes retweeted
Excited to finally have this published! Out today in @NatureComms, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. nature.com/articles/s41467-0…
1/3
Ethan Hughes retweeted
Extremely happy to share our manuscript jointly authored by me and the amazing @LindsayOsso ! An awesome collaboration between the @EthanHughesLab , @denmanlab and Autobahn Therapeutics nature.com/articles/s41467-0… 🧵
Ethan Hughes retweeted
Excited to share our work published this week! Led by myself and world class co-first @gdfnunes working in the @EthanHughesLab in collaboration with Dan Denman: nature.com/articles/s41467-0…. A short 🧵
Ethan Hughes retweeted
Our 7-year journey on glia-like taste cells is finally published in @CellCellPress! We report how the glia-like cells shape sweet adaptation on the tongue. Huge thanks to our lab members, especially Ghayeon & Geehyun, and collaborators @yulonglilab. cell.com/cell/fulltext/S0092…
Ethan Hughes retweeted
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
biorxiv.org/content/10.1101/…
Ethan Hughes retweeted
Online now: White matter aging and its impact on brain function dlvr.it/TG94g9
Ethan Hughes retweeted
Cool!
Learning-associated astrocyte ensembles regulate memory recall
nature.com/articles/s41586-0…
Ethan Hughes retweeted
Our work with @schirmerlab in multiple sclerosis (MS) is out today in @NatureNeuro. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️
nature.com/articles/s41593-0…
Ethan Hughes retweeted
Agreed! That's why I wrote ggpubfigs, a ggplot2 extension that *only colorblind-friendly color palettes.
Easily make your figures colorblind-friendly with ggpubfigs! xitter.cf/NKWhiteman/status/1852…
Ethan Hughes retweeted
🚨 Cues of trained immunity in macrophages of Multiple Sclerosis patients... Curious to know more? 🔍
Dive into our latest paper showcasing the fantastic work by Jennifer Fransson! 🧾✨
#MultipleSclerosis #TrainedImmunity #OpenAcess
@InstitutCerveau
neurology.org/doi/10.1212/NX…
Ethan Hughes retweeted
My second manuscript from graduate school is now on bioRxiv! We generated a comprehensive scRNA-seq dataset of mouse OPCs from young adult to aged animals with the hope of providing a reference dataset for everyone to dig into! tinyurl.com/aging-opcs
Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan biorxiv.org/cgi/content/shor… #biorxiv_neursci
Ethan Hughes retweeted
nature.com/articles/s41467-0…
I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:
Ethan Hughes retweeted
Important work from Fraser Sim's lab-keep in mind for MS:
"Clemastine Induces Oligodendrocyte Progenitor Pool Exhaustion and Senescence in the Context of Chronic Demyelination in a Rabbit Model" onlinelibrary.wiley.com/doi/…
Ethan Hughes retweeted
New work from @Anpietra that defines in vivo mitochondrial morphometrics and dynamics in microglia. Alicia discovered that mitochondria are rarely present in surveillant or injury-responding processes.
biorxiv.org/content/10.1101/…
@MCBDartmouth @DartmouthNeuro @dartmouthartsci