'Everything I disagree with is stupid unless proven otherwise!'
@FuchsWriter and @camjenglish explain why pro-science voices need to:
- Follow the evidence consistently
- Accept uncertainty where it exists
Matt Fuchs retweeted
Debunking "junk science" is fun, and necessary.
But what happens when our skepticism goes too far?
"Skepticism can become more than a process for truth-finding...maybe even a brand or an identity," says veteran science journalist @FuchsWriter.
Matt Fuchs retweeted
Real impact happens on and off the court. 🌟🎾 Our 2025 Impact Report is officially live! Read the full story and explore the milestones we achieved together: vist.ly/5env2
#ustamidatlantic #ImpactReport #PlayTennis
Matt Fuchs retweeted
Today in @NatureBiotech we report OptiPrime, a mechanism-based machine learning model for predicting prime editing (PE) efficiencies and suggesting pegRNAs to achieve a user-specified edit. OptiPrime incorporates biochemical knowledge about PE into its mathematical structure, enabling training on ~300,000 PE efficiencies collected using 40 experimental conditions in multiple labs, and outcome predictions of PE variants such as twin prime editing not used in its training. OptiPrime enabled the rapid identification of efficient PE strategies across a variety of applications in vitro and in vivo, and could outperform months or years of manual experimental optimization.
Try out OptiPrime here: optipri.me
PDF: drive.google.com/file/d/13JZ…
1/15
Matt Fuchs retweeted
🥳 Is there really a “universal” ageing clock?
⏳FYI .. my clock ≠ yours
💅Every body has its own biological timeline 🌞
nature.com/articles/s41586-0…
Matt Fuchs retweeted
Replying to @FuchsWriter
🏋🏽♀️ Always inspiring ... 💃🏽My midlife is fitter, healthier, stronger, and better than my younger self! - Pls checkout lovely articles by @FuchsWriter fuchsm.substack.com/p/the-wa…
Matt Fuchs retweeted
Lawnmower-like Enzyme Rewinds Decades of Molecular Aging in Human Tissue | The Scientist the-scientist.com/lawnmower-…
Matt Fuchs retweeted
The Biggest Tell That Something Was Written by AI
Look closely and you’ll see that every part of the text is not quite right.
🔗⮛
Matt Fuchs retweeted

Brady Holmer@Brady_HJul 9
🇺🇸
United StatesConnected via United States App StoreAccount-level information, not a live location or per-post device.
This sentence. 🤌
"Physical activity is a canonical characteristic of humans... the normalization of the lack of physical activity has led to the perception that physical activity is an intervention even though it remains as the modus vivendi engrained in our genes."
Brady Holmer@Brady_HJul 9🇺🇸
United StatesConnected via United States App StoreAccount-level information, not a live location or per-post device.
Wow.
We might be able to identify mitochondrial dysfunction with a simple treadmill test.
This new paper by @doctorinigo proposes that two key metrics can serve as a “reliable, early physiological signature of subclinical mitochondrial dysfunction.”
• A blood lactate level above 2.5 mmol/L
• A fat oxidation rate below 0.4 g/min during moderate exercise (50 to 60 percent of VO2 max)
Matt Fuchs retweeted
Long-term exposure to certain types of air pollution linked to increased risk of Parkinson’s disease, Cambridge researchers find 🔗⮛
Matt Fuchs retweeted
😋 My food is pretty healthy... lots of veggies 🥬, fish (love Fremantle sardines 🐟), Aussie roasted almonds, macadamias & Aussie olive oil ...
🤔What other healthy fats should I add? 👇🏽Great list by @FuchsWriter in @TIME time.com/article/2026/06/26/…
Matt Fuchs retweeted
How does early life adversity (ELA) impact the epigenome across the body & brain? Amazing new work from the @CayoBiobank led by @baptistesadou @SMack_Lab & Amanda Lea. By generating multitissue DNA methylation data across the life course in animals with known social histories, we reveal a fundamental contrast in epigenomic remodeling: Age-linked epigenetic variations are highly tissue dependent, but the molecular effect of early life adversity represents a more coordinated, organism-wide response. Congratulations to the entire team! science.org/doi/10.1126/scie…
Matt Fuchs retweeted
These ‘master’ proteins protect us from deadly mutations — and could inspire new drugs > Biology has clever ways to mask the effects of potentially harmful gene mutations. Scientists are investigating how this ‘buffering’ works — and how to exploit it, writes Philip Ball.
nature.com/articles/d41586-0… @Nature
Matt Fuchs retweeted
Big new UK Biobank study (89,537 people, wrist accelerometers, 761 diseases tracked): sedentary time is linked to higher risk of 75 diseases — cardiovascular-kidney-metabolic conditions top the list.
jacc.org/doi/10.1016/j.jacad…
Matt Fuchs retweeted
Replying to @FuchsWriter
If you want the full breakdown of these 4 half-truths and why they're key to healthy aging, head to Prime Factors for the complete post:
fuchsm.substack.com/p/4-half…
Matt Fuchs retweeted
Is bread actually healthy? The answer is more nuanced than a simple yes or no.
In this recent @TIME article, Pennington Biomedical's Dr. Candida Rebello helps break down what the science says about bread, whole grains and how different types of bread can fit into a healthy eating pattern.
Read more to learn why the type of bread you choose matters and what researchers are discovering about its role in overall health at time.com/article/2026/06/15/… #PenningtonBiomedical #NutritionScience #HealthyEating
Matt Fuchs retweeted

Eric Topol@EricTopolJun 15
🇺🇸
United StatesConnected via United States App StoreAccount-level information, not a live location or per-post device.
In a randomized trial of people with prediabetes, lifestyle improvement vs metformin or placebo, lifestyle was best for prevention of chronic conditions
@JAMA_current
jamanetwork.com/journals/jam…
Matt Fuchs retweeted
Microplastics are everywhere. They're in our food, our water, the air we breathe, and—according to recent research—even in the human brain.
But how concerned should we actually be?
In the latest episode of Longevity Science with Matt Kaeberlein, I sat down with environmental toxicologist Dr. Matt Campen, one of the leading researchers studying microplastics and other environmental exposures, to separate what the science tells us from the hype.
We discuss:
🧠 What researchers have found in human brain tissue
🥩 Why food may be a bigger source of microplastic exposure than most people realize
🧬 The emerging links between microplastics, dementia, and aging biology
🔥 How wildfire smoke affects brain health and cognitive function
☣️ Heavy metals, air pollution, and other environmental risks that deserve more attention
🏛️ Why meaningful solutions will likely require policy and infrastructure changes, not just individual behavior
One of the things I appreciated most about this conversation is Matt's balanced perspective. Despite being at the forefront of this research, he's not advocating panic or drastic lifestyle changes. Instead, he emphasizes the importance of understanding the evidence, recognizing uncertainty, and focusing on the interventions most likely to have meaningful impact.
As with many topics in longevity science, the challenge is separating legitimate concerns from fear-driven narratives and marketing claims. This conversation is an excellent example of how to approach a rapidly evolving area of research with both curiosity and scientific rigor.
Check out the full interview here: youtube.com/watch?v=J64kHdKN…
Matt Fuchs retweeted
techxplore.com/news/2026-06-… @TechXplore_com
Thirty-five AI comedians walked into a workshop, and what happened next could reshape how machines learn humor
Matt Fuchs retweeted
Researchers increasingly believe the 40s, 50s and 60s represent a critical window for protecting cognitive health later in life, suggesting dementia is driven by years of metabolic stress, inflammation and vascular damage accumulating across the body. wapo.st/4ehdfaz






















