As you may already know well, "young patients who experienced a second confirmed SARS-CoV-2 infection during the omicron period were more than twice as likely to receive a clinician-documented diagnosis of post-acute sequelae of COVID-19 (PASC) as those in the same calendar period after a first infection.. [In this cohort study of >465,000 patients younger than 21 years,] the incidence of clinician-documented PASC was roughly 1,884 cases per million children after a second infection, compared with about 904 cases per million after a first infection.. Beyond formal PASC diagnoses, children and adolescents who experienced reinfection had an elevated risk of a wide range of symptoms and conditions previously associated with long COVID. These outcomes spanned multiple organ systems, including: - cardiovascular complications such as myocarditis, arrhythmias, heart disease and chest pain; - neurologic and cognitive effects such as headaches, cognitive impairment, postural orthostatic tachycardia syndrome (POTS) and other forms of dysautonomia; - kidney injury; - thrombotic events; and - more common symptom clusters including fatigue, abdominal pain and musculoskeletal pain. Myocarditis risk was more than three times higher after a second infection, and the risk of thrombotic events more than doubled.. These findings directly contradict the common assumption that because acute omicron illness is usually mild in children, and reinfection is clinically inconsequential.." SARS-CoV-2 is different. 'Reinfection raises Long COVID risk in children and adolescents' news.feinberg.northwestern.e…