News from Dr. Mahendran K.R's group @RGCB_Trivandrum Single-molecule sensing with protein nanopores.
RGCB,Thiruvananthapuram,India
Joined November 2020
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Our publication in Nature Nanotechnology is out.
Big milestone for us and the beginning of many more to come. nature.com/articles/s41565-0…
Special thanks to my fantastic collaborators @Krishnanandac and Ulrich.@RGCB_Trivandrum @NatureNano @DBTIndia @ICMRDELHI @CSIR_IND2
Mahendran KR, Membrane Biology GROUP retweeted
#researcherspotlight Archana Samal @ArchanaSamal10 from Dr. Dileep Vasudevan @dileepvasudevan @lab_vasu lab @RGCB_Trivandrum @ILSBhubaneswar talks about her work on "Ani2: A Dual Chaperone Linking Histone Assembly and Protein Folding in Yeast" biopatrika.com/academia/rese…
This is fantastic. Congratulations Christos.
In our latest article we describe the first structure(s) of E coli #MscL in lipids and two conformations, solved by #cryoem. EcMscL was the first #mechanosensitive channel identified. #epr #peldor identified conditions to obtain the open-like state
nature.com/articles/s41467-0…
Membrane proteins again.
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
Biology beyond boundaries.
From Discovery to Impact: Building Bridges Across Disciplines
An exceptional gathering of scientific minds came together for an engaging and thought-provoking panel discussion in presence of Dr. @rajesh_gokhale Director General, BRIC Secretary, Department of Biotechnology, Government of India and invited speakers, moderated by Dr. Pushkar Sharma, Director (Additional Charge) and Dr. Gopalan Sampathkumar, Senior Scientist, @NImmunology .
The discussion brought together diverse perspectives, challenged conventional thinking, and explored the potential of courageous, bigger and bolder ideas that can build bridges across disciplines and translate scientific discoveries into meaningful impact.
The Secretary encouraged scientists to look beyond the laboratory, pursue innovation with a broader societal vision, and focus on creating jobs and opportunities through research and scientific enterprise.
#NIIFoundationDay #BiologyBeyondBoundaries #BRICNII #ScientificResearch
@DrJitendraSingh
@rajesh_gokhale
@BricDbt
@DBT_inStem @NABI_India @bric_ils @HydNiab @FollowDbtNibmg @NIPGRsocial @NImmunology @BRIC_CDFD @DBT_NCCS_Pune @ICGEB @DBT_inStem @DBT_NBRC @RGCB_Trivandrum @DBT_IBSD @THSTIFaridabad @unescorcb @CSIR_IND @ICGEBNewDelhi @BIRAC_2012 @CSIRIndia @DSTI
Fantastic symposium @bric
Dr. Mahendran K. R., Scientist E-II at @RGCB_Trivandrum, is presenting his work on engineering transmembrane pores.
His lab studies how these tiny pores work and how they can be used to detect biomolecules and chemicals.
This research may help develop new biosensors and therapies.
#NIIFoundationDaySymposium2026 #BRICNII #Biosensors #MembraneBiology
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@DBT_inStem @NABI_India @bric_ils @HydNiab @FollowDbtNibmg @NIPGRsocial @NImmunology @BRIC_CDFD @DBT_NCCS_Pune @ICGEB @DBT_inStem @DBT_NBRC @RGCB_Trivandrum @DBT_IBSD @THSTIFaridabad @unescorcb @CSIR_IND @ICGEBNewDelhi @BIRAC_2012 @CSIRIndia @DSTIndia
Those who are interested can apply for this.
Applications are invited from suitable candidates (Indian citizens) for one position of Project Research Scientist-I (Non-Medical) in the ICMR/MAHA MedTech-funded project titled “An AI-Integrated Ultrasensitive Nanopore Sensing System for Non-invasive Early Detection of Cervical Cancer” to work in the Laboratory of Dr. Mahendran K R, Scientist – E-II, at Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram, Kerala.
Link to application portal: rgcb.res.in/adv-2026-10
Last date for receiving the filled application: 14th October 2026
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Mahendran KR, Membrane Biology GROUP retweeted
Applications are invited from suitable candidates (Indian citizens) for one position of Project Research Scientist-I (Non-Medical) in the ICMR/MAHA MedTech-funded project titled “An AI-Integrated Ultrasensitive Nanopore Sensing System for Non-invasive Early Detection of Cervical Cancer” to work in the Laboratory of Dr. Mahendran K R, Scientist – E-II, at Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram, Kerala.
Link to application portal: rgcb.res.in/adv-2026-10
Last date for receiving the filled application: 14th October 2026
@DrJitendraSingh
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@IndiaDST
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Mahendran KR, Membrane Biology GROUP retweeted
How do plants turn local wounding response into a whole-plant defense?
Our work identifies CNGC13, a vasculature localized Ca²⁺ channel that helps propagate systemic Ca²⁺ waves and activate jasmonate & glucosinolate defenses in Arabidopsis.
A new piece of the puzzle in long-distance plant immunity and wound signalling and acts in parallel to well known GLR channels
First PNAS from my lab and is combined efforts of a great team : Misha @MishaKu16647918 and Ramgopal as first authors. Supported by Bhawana @BhawanaSha17 and Mahendra @MahiPawar12 from lab
We thank Alex Costa @lab_costa for his constant support and collaboration ; Yong-Fei Wang for electrophysiology
A huge shout out to @DBTIndia @NIPGRsocial for funding and encouraging basic plant science in India and Arabidopsis research
pnas.org/doi/10.1073/pnas.26…
Strongly recommended.
wo positions open in the Maglia Lab in Groningen! We're looking for a PhD student and a postdoc to push the frontier of single-molecule nanopore science — .
Visit us at: sm-biophysics.com/jobs
Mahendran KR, Membrane Biology GROUP retweeted
Dr. Jackson James (Scientist, Regenerative Biology Program, BRIC-RGCB) and his team were awarded Rs. 7 crores from the Mission for Advancement in High-Impact Areas (MAHA) MedTech Mission grant launched by Anusandhan National Research Foundation (ANRF) in collaboration with the Indian Council of Medical Research (ICMR) and the Gates Foundation. The project is being carried out at BRIC-RGCB in collaboration with a start-up, IndZita Biotech Private Limited, Thiruvananthapuram, and Karkinos Healthcare Private Limited, Mumbai. The device works by detecting piRNA-based biomarkers in blood and measuring them using nanopore technology, a highly sensitive method of detecting molecules at the nanoscale. Dr. K. R. Mahendran (Scientist, Transdisciplinary Biology Program, BRIC-RGCB) and Dr. Ani V. Das (Senior Program Scientist, Cancer Research Program, BRIC-RGCB) are also part of this major grant.
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Looking forward to this.
The programme for the NII Foundation Day Symposium 2026 is taking shape!
On 5 October, Celebrating Biology Beyond Boundaries will bring together scientists working across genomics, ageing, neuroscience, venomics, biomarker discovery, immunity, cell biology and more.
Meet our speakers and explore the programme.
Many frontiers. One celebration of biology.
📍 BRIC–NII, New Delhi
Registration 🔗forms.gle/LuSEcPeJ4xLUFZDF8
@DBTIndia @BricDbt
Mahendran KR, Membrane Biology GROUP retweeted
A new publication from the laboratory of Dr. Dileep Vasudevan (Scientist, Transdisciplinary Biology Program, #BRICRGCB) appeared in the journal "International Journal of Biological Macromolecules," and the title of the manuscript is "Entamoeba histolytica NAP1 is a versatile histone chaperone for both H2A/H2B and H3/H4." The manuscript can be accessed at sciencedirect.com/science/ar….
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Congratulations, Dileep and Archana @lab_vasu @dileepvasudevan
A new publication from the laboratory of Dr. Dileep Vasudevan (Scientist, Transdisciplinary Biology Program, #BRICRGCB) appeared in the journal "International Journal of Biological Macromolecules," and the title of the manuscript is "Unravelling the structure-function features of Ani2, a dual chaperone from Schizosaccharomyces pombe." The manuscript can be accessed at sciencedirect.com/science/ar….
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Mahendran KR, Membrane Biology GROUP retweeted
藤田さんの無細胞ナノポア発現の成果がACS Nanoに掲載されました！28残基は最小の無細胞タンパク質発現！？
doi.org/10.1021/acsnano.5c15…
Mahendran KR, Membrane Biology GROUP retweeted
New Huang Lab publication in Nature Biotechnology. We report an AI-inspired molecular adapter that enables the first unified nanopore sensor capable of simultaneous glycomics, proteomics, and transcriptomics measurements using a single sensing platform. rdcu.be/wxKzEPFjRNna
Mahendran KR, Membrane Biology GROUP retweeted
An engineered nanopore identifies saccharides, amino acids, peptides and ribonucleotides nature.com/articles/s41587-0…
Mahendran KR, Membrane Biology GROUP retweeted
Mechanism of membrane perforation in rotavirus cell entry
science.org/doi/10.1126/scie…
Mahendran KR, Membrane Biology GROUP retweeted
Fluorescence lifetime as a barcode: HaloTag-nanobody fusions give one dye four distinct lifetimes, imaging 8 protein targets in a single staining step on a standard confocal FLIM. #NanoFLex
Read it here 🔗 go.acs.org/eE3
Mahendran KR, Membrane Biology GROUP retweeted
Nature research paper: Creating bottom-up RNA transfer vehicles from synthetic protein assemblies
go.nature.com/4ymcLbW
Mahendran KR, Membrane Biology GROUP retweeted
New paper:
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling.
"Tunable α-helical octameric #nanopores assembled from engineered #peptide enable programmable biomolecular #sensing."
bsky.app/profile/natnano.nat…
nature.com/articles/s41565-0…
