Man of Science 🧬 AI & Gerophysics to understand Aging. 🇸🇬 Rethinking the Fundamentals of Aging & Rejuvenation Biology @TTIScience 🇺🇸

Singapore & Europe
Joined October 2018
Max Unfried retweeted
Am I missing something? Where do the inputs to train this simulation come from? Compute is not the bottleneck in biology. It’s estimated we have only sequenced genomes for 1% of eukaryotic species, and DNA is just the beginning. Infinite compute can’t help you simulate a system that’s never even been observed or measured.
If you had an exponential amount of compute you could solve simulate biology exactly and wouldn't need to run any experiments. Some of you will think "of course, but that's an unrealistic assumption" and others will think "no, you need experiments even with that much compute. That's just How It's Done". You would of course need evaluations once you have a solution, but you don't in principle need experiments to find it: Experiments are a way to save compute, dating from a time when it was much more expensive. And I think the presentation is exponential but real systems aren't irreducibly exponential. AlphaFold worked, after all.
29
23
4
287
14,780
Max Unfried retweeted
I’m convinced 95% of being a high performer is to just do 5 things: - Be obsessed like a psychopath - Have delusional optimism - Avoid unserious people - Take asymmetric risks - Be relentless
73
534
25
5,141
95,448
Max Unfried retweeted
Fantastic Junior Group leader position at the Curie Institute in Paris!! Areas of interest include stem cells, tissue growth and morphogenesis, epigenetics, genomics, integrated physiology, metabolism, and synthetic embryo models. Please RT! jpi-recruitment-curie-umr321…
15
24
3,356
Max Unfried retweeted
Now can self custody your startup. We are live.
Obolos is LIVE on mainnet! We’re building the capital coordination layer for agents and humans. One protocol bringing together cap tables, fundraising, shareholder management and equity workflows, from pre-seed to pre-IPO. Here’s how it works 🧵 Built on @arbitrum and @fhenix.
3
1
7
228
One codon-level therapy can hit nonsense mutations shared across multiple aging diseases. Brian Bodemann (ARTAN Bio) at #ARDD2026. Photos: agingpharma.org/photos2026
1
4
14
1,641
"The most valuable thing in the industry is data on how the human body will respond." @impetusgrants' round on datasets enabling AI to reason about aging and disease will fund ~50 projects to proactively get this data ready for new models. >9/15M raised, tell your friends to donate so we can get going.
Dialectic 60: Patrick Hsu! @pdhsu & @arcinstitute are combining biology, engineering, and AI to turn a sci-fi future into reality. Patrick got expelled from college at 13, returned at 15, later worked on early CRISPR breakthroughs, and teamed up with @SKonermann & @patrickc to found Arc. He works 3 jobs: core investigator at Arc, professor at Stanford, and venture partner at @thrivecapital. For all his intensity and ambition, he carries a lightness and boldness that is contagious. We discuss: - why research is 99% failure and even your best ideas kind of suck - infinite games and speedrunning school - the reach of GLP-1s and power laws in biotech - what makes a good biologist - Arc’s bet on people over projects - lab robots that finally work - AI-designed organisms and new forms of life - why heart disease could go the way of infectious disease - bro science, peptides, and biofuturism - research taste in the age of AI Timestamps: (0:00) Opening Highlights (1:39) Intro: Patrick Hsu (4:29) Start: Boldness, Infinite Games, & Ambition (12:54) GLP-1s and Power Laws in Biotechnology (20:17) Expelled at 13 and Falling for Biology (25:51) What Makes a Good Biologist, Research Taste, and Biology's Data Challenges (37:58) The Arc Model: Full-Stack Science (52:01) Betting on People, Style, & Learning to Simplify (57:22) Perturbation, World Models, and Evo (1:03:27) Virtual Cell Models (1:09:56) Designing Life: From Stem Cells to Genome Writing (1:18:39) Testing, Bro Science, and Human Data (1:24:26) Can It Exist vs. Will It Exist: Science Meets Markets (1:29:59) Biofuturism: Interoception, Peptides, Muscle Modulation, Sleep, and New Forms of Life (1:43:47) Fun, Obsolescence, Going Slow, and the Future @dialecticpod 60: Patrick Hsu - Speedrunning the Infinite Game - is available on all platforms, including X. Links below.
1
14
35
3,888
— This is the Amber Heard type who destroyed David Sabatini’s life and career. He may have gotten a big judgement against her from the jury, but he will likely have to fight to see even a penny of it. Meanwhile she gets to continue her illustrious career at MIT as a prof with her own lab. Disgusting.
71
280
19
2,552
128,139
Yesterday, phones across Japan lit up with an alert for a magnitude 9.9 earthquake. Luckily, it was a false alarm. Tbh, the whole country has been preparing to build through earthquakes for decades. I still remember the drills at school, and watching our cities rebuild to stricter quake codes. Most of that know-how still stays at home. Meanwhile Turkey, Indonesia, the Philippines, Chile, Mexico and California all need it. If you're building a company that takes Japanese disaster-proof engineering to the world, I want to meet you.
Japan's Meteorological Agency accidentally issued an early warning for a 9.9-magnitude earthquake. The real magnitude was 6.9, according to the USGS. No tsunami alert.
2
20
1,294
Replying to @BillAckman
@BillAckman supported David despite all adversities and massive pressure from the court of public opinion. Read his tweet till the end as it contains critical detail
Bill Ackman
@BillAckmanOct 17
Five years ago, an important miscarriage of justice occurred. The story began in April 2018 when David Sabatini, an MIT, Howard Hughes Medical Institute (HHMI), and Whitehead Institute scientist and professor began a consensual intimate relationship with Dr. Kristin Knouse, a principal investigator with her own lab at the Whitehead. By January 2020, David sought to end the relationship, but Knouse apparently did not want it to end. When David thereafter started a new relationship and Knouse learned about it, she began a secretive campaign to destroy him by attempting to end his career as a scientist. She did so by damaging his name, reputation, and that of his family with false sexual harassment and other claims, thereby making him unemployable. Knouse conspired with Dr. Ruth Lehmann, the then- and still current Director (i.e., President) of the Whitehead Institute, in her efforts to destroy Sabatini. The record presented in court demonstrated that Dr. Lehmann committed to Knouse in October of 2020 that she would fire David. Dr. Lehmann made this commitment to Knouse before any investigation of the facts had taken place. Seven months after committing to fire him, in March of 2021, Dr. Lehmann, on behalf of the Whitehead, hired the law firm of Hinckley, Allen, Snyder (HAS) to undergo an investigation of David. By July 2021, HAS shared a draft of its conclusions with MIT, HHMI, and the Whitehead, but not with David or his lawyers. On the morning of August 19, 2021, David for the first time received the more than 200-page investigative report and a calendar invite for a meeting the following day with Dr. Lehmann, the president of HHMI, and the HR directors of both institutions. The report was riddled with errors and unsupported claims about David and his relationship with Knouse. When David's lawyer immediately thereafter reached out to Whitehead counsel to ask whether David was about to be fired, they confirmed that he would be terminated at the meeting. On the advice of his lawyer, David immediately resigned from HHMI and the Whitehead rather than attend the meeting. HHMI did not accept his resignation, choosing instead to fire him. MIT put David on leave and ultimately revoked his tenure. David thereafter resigned from MIT. On August 20, 2021, one day after sending David the HAS report and before David had the opportunity to dispute the facts and the conclusions of the investigation, Dr. Lehmann emailed all employees at the Whitehead informing them that David had violated a number of Whitehead policies "including policies concerning sexual harassment." The Lehmann public email, David's resignation and firing, and Dr. Lehmann's claims about David's sexual harassment exploded into a major global scandal covered in mainstream, social, and scientific media around the world as it had all of the requisite ingredients: An attractive target with David, one of the most important scientists of his generation in line for the Nobel Prize, a purported inappropriate sexual relationship with a younger female colleague, and a political and institutional environment where punishing a man for sexual harassment advanced the career and reputation of the person and/or institution that destroyed the career and reputation of the accused, regardless of the validity of the allegations. As a result of Knouse's claims, Lehmann's sham investigation, and the media onslaught that followed, David lost all sources of income and his reputation was destroyed. All prizes he had been previously been awarded were withdrawn. He was removed from all scientific advisory and other honorary roles other than as a member of our family foundation's (the Pershing Square Foundation's) scientific advisory board. When I initially learned of the news about David in the summer of 2021, I hired him as a consultant to the Pershing Square Foundation as I believed our small foundation team would benefit greatly by his insights (and he now had the time to help us), and he needed the money to support his family. At my request and under a confidentiality agreement, David provided us with many hundreds of pages of documents including texts and other communications with Knouse, the investigative report, and David's responses to the allegations so that we could do our own evaluation of Knouse's claims. I and a member of our family office's legal team carefully reviewed the documents. After a careful review of the empirical documents -- in particular the texts between Knouse and David -- it became abundantly clear that Knouse's actions were that of an angry and jilted lover, not those of a sexually harassed junior colleague. And the investigative report appeared designed to deliver a pre-ordained conclusion rather than a dispassionate fact-based analysis. The impact of the firings and the destruction of his career and reputation on David and his family was extraordinarily devastating, so much so that we became increasingly concerned that he might commit suicide. [In order to make sure that David's important scientific research would continue, in February 2023, in partnership with an anonymous donor, we funded $25 million to support David launching a new lab. As you might expect, I was reviled in the press, in scientific journals, and on social media for doing so and for supporting a so-called sex offender.] On October 20, 2021, David filed suit against Knouse alleging defamation and tortious interference in his career and his contractual arrangements. Thereafter, Knouse brought counterclaims against David. Today, nearly five years to the date of the filing of the suit, he has finally received justice. Today, a 13-person jury (seven men and six women) of David Sabatini's peers (12 jurors plus an alternate) unanimously determined that David proved that Kristin Knouse defamed him, tortiously interfered with his contractual relationships (his entire career as a scientist), and tortiously interfered with his prospective advantageous relationships (his future employment). The jury awarded him nearly $10 million in damages including interest. The jury rejected all of Knouse's claims including her claims that David engaged in quid pro quo sexual harassment and created a sexually hostile work environment. While five years is a very long time to live under a reputational cloud, justice was finally served today for David, but not completely in my view. To this day, Dr. Ruth Lehmann remains Director of the Whitehead Institute. Dr. Lehmann worked alongside Dr. Knouse to destroy David Sabatini, an acclaimed scientist and professor. She did not follow due process before she intentionally destroyed David's career and reputation. Dr. Lehmann nearly killed David with her actions, as had we not rescued David by finding him employment, supporting him publicly to buffer the reputational damage, and supporting his recovery, he could have ended his life and left his son without a father before the world understood what had transpired here. And the reputational damage was not just to David. David's brother, Bernardo Sabatini, is one of the most important neuroscientists in the world. To this day, he has had to deal with a large cloud over his family name and reputation. Recently, when the new CEO of our brain institute mentioned that Bernardo Sabatini was on our board, he was asked: "Wasn't he involved in some kind of sex scandal?" For obvious reasons, the character of the person who runs a scientific institute is of utmost importance. Among other failures here, Dr. Ruth Lehmann committed to Knouse that she would fire David many months before an investigation was even launched and without consideration of the empirical facts. How can one trust research produced by a scientific institute if its leader is not committed to observing the empirical facts before reaching conclusions that have life-threatening import? We have unfortunately seen massive amounts of scientific fraud which has harmed innumerable human lives and wasted billions of dollars of research funding and time. For her ethical breaches here, Dr. Lehmann should be fired from the Whitehead. Based on her actions in this case, she is in no position to serve as the leader of an important scientific institute. I speak with some perspective on how scientific and other institutions should be led. Including the recent launch of the Ackman Oxman Institute, we have funded approximately $1 billion of scientific research and institutions over the last decade or so, and this experience has given us the opportunity to meet the leadership of many of the most important scientific institutions in the world. To put it plainly, we would not give a dollar to a scientific institute whose leader compromised basic moral principles as has happened here. At an absolute minimum, the board of the Whitehead should immediately launch a detailed and independent investigation of Dr. Lehmann's actions in the Sabatini case. I would encourage the investigation, among other considerations, to carefully exam all of the correspondence between Lehmann and Knouse, as well their correspondence with the HAS law firm on among other areas, the various drafts of the Sabatini investigative report. Alternatively, Dr. Lehmann could resign, minimize further distraction for the Whitehead, and save institutional time and resources that would be better spent on research that benefits humanity.
3
31
2,558
Menopause dynamics reveal "a physiological cliff [...] absent in male individuals" Another fantastic paper by the @UriAlonWeizmann lab! Really interesting to see change by marker and surprisingly not as bad as I'd expect for health outcomes (apart from osteoporosis, arthritis, bronchitis and sleep) nature.com/articles/s41591-0…
5
16
1,017
Max Unfried retweeted
we're recruiting a leader for our RNA process & production team @newlimit this role will have an impact on all the products in our portfolio. you'll explore frontier chemistry, train and lead talented scientists, & shepherd products to the clinic. DM me if you're interested!
2
13
66
5,466
Max Unfried retweeted
What ^ founders felt @ that YC sound bath wasn't magic. It was trance, a normal brain state you drift in / out daily. On 10/10 @hellosimar & I are demystifying what hypnosis can unlock. Then we'll do it live on the entire room. Limited space. Apply to join luma.com/r6lmqlg9
Attended a sound bath session at @ycombinator Reboot and experienced a strange sensation. Talking to fellow YC founders made me realise that some went into a state of trance. Posted this experience on X and a friend told me he's a trained hypnotherapist from last 10 years and HYPNOSIS IS REAL! I am a founder, a man of science. Skeptical of such claims but my friend is legit. So, I am hosting this intimate event with him to explore this domain. Link - luma.com/r6lmqlg9
8
2
16
1,018
Max Unfried retweeted
Why do small dogs live longer than large dog species, and what is the biologic basis of differences in lifespan and healthspan? Epigenetics. There's a lot in the methylation pattern of dogs to explain this @ScienceMagazine science.org/doi/10.1126/scie…
20
113
6
476
47,265
Very happy to see this specifically: “$400 million supports new technologies that expand what biologists can measure.” Bio AI shouldn’t just be trained on what happens to be easy to measure. We should think much harder about which variables we need to observe to actually predict biology, and eventually uncover the rules that drive cell state change
🧵 Biohub, @ENERGY, @NIH, and new funding partners today announced a major expansion of an international effort to generate and make accessible the data enabling predictive AI models of biology. Together, the organizations are investing $1.8 billion in funding, data, computation and new measurement technology - largest coordinated commitment to map the biology of the cell to power development of digital models of biology. bit.ly/3UhjoxD
2
1
9
760
Max Unfried retweeted
Dr. Alex Voda
@DrAlexVodaOct 6
Presenting in front of $1T pharma companies, data scientists and clinicians at @ARDD_Meeting has been an amazing experience! 🥳 We spoke about our reproducibility-aware AI drug discovery models; they've enabled us to improve our tx pipeline and brought us successes in clinical trials, saving feline lives. We're now partnering with pharma to bring those therapeutics to the pharmacy shelves. Having first saved feline lives (with massive improvements in the blood urea of elderly cats, as well as creatine, blood phosphorus), we shared precisely how the data moat we generated may apply to human medicine (and a few other mammalian species) for kidney, musculoskeletal and brain age-related diseases. Many companies and academics have followed up on our presentation with in-person questions, followed with X messages and emails. After all, the ARDD team (led by the incredible @biogerontology, @DomiWilczok, @MaxUnfried et al.) have done an amazing job at bringing longevity biotech and the largest pharma companies together in one place. I apologize if I'm slow to reply for a few days (like 3-4) but I promise I will get back to every single message on these exciting results! @thecathealthco
4
5
16
364
WHERE'S ED BOYDEN? Oh. He was only a PhD student when he co-invented optogenetics and performed the first demonstration, so he gets no credit. Instead his advisor gets all the credit. From National Academy of Sciences: Boyden, "in parallel to his PhD, as an independent side project, co-invented optogenetic control of neurons." One of the worst snubs in Nobel history IMO!
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
61
259
80
2,060
288,850
Max Unfried retweeted
Replying to @MaxUnfried
@MaxUnfried smashing conventional thinking on biological progress at @ARDD_Meeting
2
5
148
Highly positive panel on longevity trials at ARDD: Lowell Zeta (chief of staff) says longevity is a priority for the current FDA. There's now a point person for longevity trial design: Justin Penzenstadler (reviewer on GLP1s). Steven Kozlowski (chief scientist) working on guidance and tech specs, to be released first half of next year. Justin recommends the field forma precompetitive consortium for which biomarkers, how to include in trials. And to talk to regulators regularly.
7
28
7
132
14,455
Brian Christine, Deputy Assistant Secretary for Health at HHS, delivers the Policy & Regulatory Address at #ARDD2026. Regulatory science meets longevity drug discovery. Full program: agingpharma.org/program2026
1
2
11
1,504