paramveer singh retweeted
Today is World Marrow Donor Day, a day dedicated to saying #ThankYouDonor to all who have donated marrow, cord blood or are on the registry. Learn more about how you can participate: worldmarrowdonorday.org/ #WWMDD24 @MarrowDonorDay
#AMLsm 70yr healthy man developed pancytopenia, diagnosed with adverse risk AML [JAK2 V617F VAF ~ 40%,rest NGS negative, complex karyotype with 5 q(-), 20 q(-), refractory to 7+3 [100 and 60], is day 12 of Aza-Ven [75-100], blast count trending up after 7 days of Aza. Next step?
Hi #AMLsm, do you perform day 14 bone marrow biopsy after 7+3 induction in newly diagnosed AML?
83%yes, we do day 14 BM
17%no, we do not day 14 BM
0%depends [pl comment]
6 votes • Final resultsA 65-year-old man with pancytopenia was found to have MDS on bone marrow biopsy with 3-4% CD34 blasts, normal cytogenetics, NGS BCOR 5%, SRSF2 50%, & RUNX1 5%. IPSS-R int, IPSS-M high. Transplant eligible. CBC stable, on monitoring. Would u recommend a transplant?
#MDSmm #BMTsm
29%No
71%Yes
35 votes • Final results@DavidSteensma @Dr_AmerZeidan @drsomedeb @AshKishtagari @NicoGagelmann @garciamanero @TalhaBadarMD @CloneTracker @drsangeetmd @MikkaelSekeres @abhinav_deol @BloodCancerTalk @DrCCutler appreciate your inputs/comments.
paramveer singh retweeted
⚡️Applications are now open!!⚡️
🎊Be a part of a vibrant community where you can enhance your knowledge in nephrology, develop social media skills, and contribute in shaping the future of nephrology education and outreach.🎉
nsmc.blog/
Hey #CARTsm #mmsm #lympsm tweeps. Pl vote. 😊🙏
How far patients are recommended to stay from the CART center, for the first thirty days of receiving the CART product in the hospital? Per your institution/transplant unit policy. Thanks.
67%Within 30 or 60 minutes
33%Within 90 minutes
0%Within 120 minutes
0%No specific time frame
3 votes • Final results paramveer singh retweeted
2. Pip-tazo
Pip-tazo can inhibit renal clearance of methotrexate (MTX) and results in toxicity esp when high dose MTX is used (e.g. for hematological malignancy)
academic.oup.com/jac/article…
“High-dose ATO may be associated with significant nephrotoxicity. We recommend that ATO dose be capped at 15 mg to minimize toxicity for this curable disease.”
Arsenic trioxide 0.15 mg/kg without capping (15 mg maximum dose cap) may cause renal damage in obese patients with APL
@MDAndersonNews
@jenweiying @TapKadia @GBorthakur @MusaYilmazMD @fravandi1
Leukemia & Lymphoma
tandfonline.com/doi/full/10.…
Hi, #bmtsm would you recommend an allogeneic transplant (matched unrelated donor) #alloHCT to a 60-year-old secondary #AMLsm with germline #DDX41 mutation in CR1 after initial induction chemotherapy, who has a good performance status. please vote/comment. Thanks!
50%Allo, RIC conditioning
0%Allo, MAC conditioning
50%Defer Allo
2 votes • Final results paramveer singh retweeted
Excited to share our Viewpoint @JAMA_current on Maintenance of Certification Exam
@JackWestMD
@chadinabhan @VincentRK @AaronGoodman33
jamanetwork.com/journals/jam…
Insightful talk by @DholariaMD on
allogeneic transplant outcomes in
chronic neutrophilic leukemia
from @CIBMTR @TheEBMT
showing favorable outcome
➡️N 29 (excluded blastic phase)
➡️CSF3R (n =9), ASXL1 (n=4)
➡️1 yr NRM 10%
➡️1 yr OS 69%, 4yr 55%
#DAVAWhistler
@DAVAOnc #BMTsm
Insightful talk on #HLH after #CARTsm by Dr. Pullarkat @DAVAONC #DAVAWhistler
1️⃣dropping CRP after giving tocilizumab and rising ferritin useful finding to suspect HLH #pearl
2️⃣etoposide is not recommended as it can decrease the efficacy
timing lymphodepletion in dialysis patients before CART therapy #CARTsm #onconephrology @DAVAOnc @Dr_AdrianaRossi #DAVAWhistler
1️⃣ chemo dose-adjusted for ESRD (e.g., flu 20 mg/m2 instead of 30 on days -5,-4,-3)
2️⃣ dialysis 12 h after each dose of chemo
3️⃣ N=2
PMID 35227310
paramveer singh retweeted
Please don't mix fruits and a whole lot of raw green and colored veggies into a blender and make yourself a detox juice if you have pre existing liver disease.
This is the second patient this week who seems to have developed kidney injury after daily consumption of home made fruit+veggie juice.
A blend of gooseberries, beetroot, spinach & green leaves along with a host of citrus fruits is a new fad thats developing after WhatsApp and YouTube "doctors" have been promoting then as "liver health" options.
Please don't do it. It can cause OXALATE KIDNEY INJURY and the kidneys take a LONG time to recover.
