@PrunedaLab

collectively ran by the Pruneda lab, MMI, Oregon Health & Science University @ohsummi | our views are our own

 Portland, Oregon
ohsu.edu/school-of-medicine/pruneda-lab
Joined September 2019
  • Tweets36
  • Following121
  • Followers155
5Media
Great talk by Rachel Lacoursiere from @PrunedaLab regarding bacterial enzymes to understand non canonical ubiquitination #EMBOubiquitin24
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Excited to share this work from former @PrunedaLab superstar @camgroberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence! biorxiv.org/content/10.1101/…

A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas...

Ubiquitin signaling controls many aspects of eukaryotic biology, including targeted protein degradation and immune defense. Remarkably, invading bacterial pathogens have adapted secreted effector...

biorxiv.org
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Fantastic to have @jnpruneda @PrunedaLab from @OHSUSOM visiting giving a seminar on his team’s exciting work on how pathogenic bacteria use nifty effector proteins to hijack the ubiquitin system and avoid the host response. Real pleasure to have you at @DTUbioengineer, Jonathan.
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Please consider supporting @RaidenScience! We’re determined to find a way to help children afflicted with this rare #ubiquitin-related disease.
Raiden Science Foundation@RaidenScience17 Feb 2024
Our Annual Run4Raiden 5K is back! ⚡️🦓 This year's fundraising goal is to raise $60K to continue our UBA5 drug repurposing program. 🧬🔬 Sign Up or Donate Today: run4raiden.raiselysite.com @OHSUNews @jnpruneda @RuthJeanNapier
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Pleased to share the final version of this work on UBA5, available at @eLife. doi.org/10.7554/eLife.89891.…
Jonathan Pruneda@jnpruneda14 Sep 2023
New @PrunedaLab research direction: a #RareDisease of the #ubiquitin-like modifier UFM1. This sets the stage for understanding and, one day, helping kids with UBA5 disease. Inspiring to work with @RuthJeanNapier and @RaidenScience on this important topic. doi.org/10.7554/eLife.89891.…
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Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work! sciencedirect.com/science/ar…
Jonathan Pruneda@jnpruneda6 Jun 2023
What can bacteria teach us about #ubiquitin? A lot! In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you! biorxiv.org/content/10.1101/…

Bacterial mimicry of eukaryotic HECT ubiquitin ligation

HECT E3 ubiquitin (Ub) ligases direct their modified substrates toward a range of cellular fates dictated by the specific form of monomeric or polymeric Ub (polyUb) signal that is attached. How...

biorxiv.org
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New preprint identifying shared and distinct mechanisms of inactivation of the #ubiquitin E1 enzyme #UBA1 across different diseases #VEXAS #SMA #lungcancer doi.org/10.1101/2023.10.10.5… Thanks to David Beck @nyulangone, @kyliejwalters and all contributors for a great collaboration!
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Excited to share our new review on bacterial effectors that follow or break the "rules" of #ubiquitin signaling. Always a pleasure to work with @camgroberts and @tylergfranklin! embopress.org/doi/abs/10.152…

Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system

The EMBO Journal - Regulation through post‐translational ubiquitin signaling underlies a large portion of eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which...

link.springer.com
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Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Teresa Thurston@ThurstonLab12 Jul 2023
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
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Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
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What can bacteria teach us about #ubiquitin? A lot! In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you! biorxiv.org/content/10.1101/…

Bacterial mimicry of eukaryotic HECT ubiquitin ligation

HECT E3 ubiquitin (Ub) ligases direct their modified substrates toward a range of cellular fates dictated by the specific form of monomeric or polymeric Ub (polyUb) signal that is attached. How...

biorxiv.org
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Happy to share that this work is now online in its peer-reviewed form at @MolecularCell. Huge thanks to our peer reviewers for challenging us, and to my co-authors for rising to meet this challenge. Check out the final product! sciencedirect.com/science/ar…
Jonathan Pruneda@jnpruneda12 May 2022
I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.1101/…

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

The versatility of ubiquitination to impose control over vast domains of eukaryotic biology is due, in part, to diversification through differently-linked poly-ubiquitin chains. Deciphering the...

biorxiv.org
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I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.1101/…

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

The versatility of ubiquitination to impose control over vast domains of eukaryotic biology is due, in part, to diversification through differently-linked poly-ubiquitin chains. Deciphering the...

biorxiv.org
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Proud to 🚀 the #RaidenScienceFoundation including Nobel Laureate Dr. Ciechanovar, @UMassChan @PrunedaLab @StJude and @BCMFromtheLabs ..who will together develop a treatment for #UBA5, an ultra-rare neurodegenerative disease. raidenscience.org/

Raiden Science Foundation

Raiden Science Foundation's mission is to harness the power of community to develop cures for rare diseases, starting with UBA5 Disorder

raidenscience.org
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Ever tried to give a 3-minute research presentation? It isn't easy! @PrunedaLab member @camgroberts gave a fantastic flash talk at #UKcellmicro2021 this week and even won a prize! Congratulations to Cam and thank you to the organizers for such a great meeting!
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Incredibly proud of @tylergfranklin for passing his qualifying exam in @ohsummi today! It’s hard to celebrate achievements like this properly right now, but we’ll do our best. Well done Tyler!
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Now online @embojournal! embopress.org/doi/10.15252/e…
Jonathan Pruneda@jnpruneda29 Mar 2020
Our first @PrunedaLab preprint! A project initiated in the @komander_lab, we describe a family of eukaryote-like deubiquitinases encoded by bacteria to manipulate host #ubiquitin signals. 1/3
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Our first @PrunedaLab preprint! A project initiated in the @komander_lab, we describe a family of eukaryote-like deubiquitinases encoded by bacteria to manipulate host #ubiquitin signals. 1/3
bioRxiv@biorxivpreprint29 Mar 2020
Identification and characterization of diverse OTU deubiquitinases in bacteria biorxiv.org/cgi/content/shor… #bioRxiv
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Very excited our first paper from @PrunedaLab is online! We describe a fluorescence-based assay for monitoring #ubiquitin conjugation and deconjugation in real time, something that would have saved countless hours during my PhD. Great job @tylergfranklin! frontiersin.org/article/10.3…
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Pruneda Lab retweeted
HandLab@thehandiestlab27 Oct 2019
The scariest pumpkin in academia...
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