@thehandiestlab

Microbiome & the immune system: best frenemies forever. Univ. of Pittsburgh/UPMC Children's Hospital/R.K. Mellon Institute for Pediatric Research #immigrant

 Pittsburgh, PA
thehandiestlab.com
Joined October 2018
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Anti-bacterial reactivity in breast milk is heterogeneous between donors but homogeneous over time rupress.org/jem/article-abst…

Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A

We analyze the ability of breast milk–derived immunoglobulin A (IgA) antibodies to bind bacteria commonly found within the preterm infant intestinal microb

rupress.org
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Check it out—hot off the presses. A review on the complex role of the microbiome in cancer. I highly recommend writing grants with friends. @thehandiestlab @ItzDipyaman sciencedirect.com/science/ar…
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The New i4Kids Pilot Grant Proposal is now open for FY26 applications! Deadline is Wednesday, May 14, 2025. Learn more on our website. @PittPediatrics @UPMCPhysicianEd i4kids.org/news-events/news/…
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Happy to share our recent work led by postdoc @DanCorral showing that the maternal adapative immune system promotes optimal lactogenesis. cell.com/cell/abstract/S0092…

Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

Mammary intraepithelial lymphocytes enhance mammary gland differentiation during pregnancy, thereby promoting offspring fitness.

cell.com
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Such cool stuff
Nik Joshi@Joshilabyale13 Feb 2025
This is a thread on our paper by Eric Fagerberg . KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection science.org/doi/10.1126/scie…

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection

Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress...

science.org
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*Attention all mucosal immunologists/microbiologists* @ASImmunology Abstracts for #MIMS2025 in sunny Noosa are extended until the 6th of Feb @MucosalImmunol @socmucimm #sysmex @QIMRB_Institute Don't miss out, amazing line up of speakers!👇
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Feeling itchy? Pitt researchers suggest a novel way to treat inflammatory skin conditions. bit.ly/3DFTqLN
A man looking down at and scratching his arm. 

ALT A man looking down at and scratching his arm. 

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Calling @PittTweet @ChathamU @CMU_Bio undergrads interested in immunology and microbiology! Applications for @MIDSProgramPitt Scholars are due Jan 15th! Providing PAID research experiences for those from diverse and underrepresented groups. pmi.pitt.edu/research/mid-sc…
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Let's try this again - Tiffany Taylor is a rising star in immunology and I'm so excited to see her receive this HHMI award and what she will do with it: hhmi.org/news/hhmi-names-202… @HHMINEWS @Pitt_PMI @PittPediatrics @somgradpitt
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As a co-author on this paper, I’m proud to see so many scientists get ahead of potential risks from mirror life research, and hopeful that scheduled talks at Pasteur, Manchester, and NUS in 2025 will be productive. science.org/doi/10.1126/scie…
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🔥🔥🔥
PoholekLab@poholeklab11 Oct 2024
What a week with two publications from our lab! Spatial microniches of IL-2 drive lung migratory Th2 cells to allergens in NI & a review on Systems Immunology Approaches to studying T cells in npj Systems Biology. nature.com/articles/s41590-0…
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Check out our new paper and let me know if you are interested in using the Fth1-mScarlet mice. journals.aai.org/jimmunol/ar…
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What a week with two publications from our lab! Spatial microniches of IL-2 drive lung migratory Th2 cells to allergens in NI & a review on Systems Immunology Approaches to studying T cells in npj Systems Biology. nature.com/articles/s41590-0…
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In our new paper out today nature.com/articles/s41586-0…, we started with a simple hypothesis - inspired by work on IL-4/IL-13 from @itchdoctor - that an innate immune cell might control sensory neuronal detection of allergens via a secreted factor. (1/11)
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Excited to share our paper out today in @CellCellPress with @BcellBruno @Vignali_Lab! Part of a trio of papers, we show in #Melanoma, anti-PD1+anti-LAG3 therapy modifies CD8 differentiation to promote enhanced effector function tinyurl.com/2ap5w9va
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Maternal IgA regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses @thehandiestlab @D_A_Abbott doi.org/10.1101/2024.06.10.5…
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Congrats @thehandiestlab!
Pitt Department of Pediatrics@PittPediatrics13 May 2024
Congrats to our very own Tim Hand, PhD, for his Ascending Star Award from the University of Pittsburgh! Read more here and support Tim at his guest lecture on July 18th! pediatrics.pitt.edu/news/han…
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So proud of Dr. Chiaranunt, a Department of Immunooogy (UofT) alum! Well done Pailin!
UofT Immunology@ImmunologyUofT10 May 2024
Congratulations to Dr. Chiaranunt (@PhagocyticPai) for being named as a 2024 Schmidt Science Fellow! 👏🏻 Dr. Chiaranunt is a PhD alumna from the Department of Immunology at @uoftmedicine where she researched macrophages & the microbiome under Dr. Mortha's (@nkg2d1) supervision.
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Please share! We are looking for an experienced scientist to join our team @CSHL! This exciting project is in collaboration with a leading US-based venture capital firm and biotech company. Apply here: nature.com/naturecareers/job…

Research Investigator - Beyaz Lab - Cold Spring Harbor, New York

Cold Spring Harbor Laboratory (CSHL) invites applications for a Research Investigator in the laboratory of Dr. Semir Beyaz.

nature.com
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Great to hear from #TimothyHand at #HMI24 about his lab’s work to better understand and #preventNEC by optimizing the power of #humanmilk and collaborating with @hmbana4babies milk banks! @HMI_UCSanDiego @ucmilkbank @DarrenBodkinMD
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Researchers from @thehandiestlab found that the antibodies in breast milk from different donors varies greatly, but each donor’s antibodies remain consistent across pregnancies. The result opens up “a whole new area of research”: pi.tt/breastmilkantibodies @PittPediatrics
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