Company builder, author, investor, advisor. Latest book: https://xitter.cf/t.co/IDV87mIPDI. https://xitter.cf/t.co/G4vdmzYMmA LinkedIn https://xitter.cf/t.co/NKevxv0qUS

Lake Tahoe (Stateline), NV
Joined February 2009
Stress your muscles, and you grow stronger. Stress your neurons, and you grow smarter. Stress your knowledge, and you grow wiser. Stress your assumptions, and you grow sharper. Stress your limits, and you grow tougher. Stress them all, and you climb higher. Stress them too much, and you fall harder. Stress your recovery, and you stop recovering. Because stress is the stimulus. Recovery is the adaptation. Productivity is the tool. Progress is the goal. You don't reach higher by staying comfortable. You reach higher by progressively raising the bar. Push. Adapt. Recover. Repeat. And then push a little further. Evolution figured this out millions of years ago. Modern society is still arguing whether we should work harder or rest more. As if the two were mutually exclusive. The trick isn't avoiding stress. It's becoming progressively better at handling it. And knowing when to stop admiring the view and start climbing again.
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This is why I traveled from Tahoe to Milan for my PCCT
Constantly Re-Working the protocols on the Photon Counting CT scanner People usually think that you put a patient in the scanner and after a few runs the protocols is done and you start working like it's a car. It's not. The work is basically never ending and after many years of working on Photon Counting CT scanners I am still changing and tweaking the machine integrating experience, new applications, and research potential. Having at your disposal hundreds of parameters to modify is a great advantage if you know what you are doing and you how to leverage them. This is part of the constant job of a PCCT super-user.
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Not really. Until non Doctors keep thinking that the job of MDs is ”diagnosing” that’s true. Unfortunately, that’s the easy part already for many years. There plenty of other things.
I think it’s time to rethink medical school and accelerate the path to becoming a doctor, since the job has absolutely nothing to do with just maintaining book knowledge. We could probably shrink medical school length in half. And a good portion of that time should be how to leverage AI to diagnose things
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Just ordered Longevity Unmasked by @afshineemrani. As someone who’s spent the past 3 years immersed in cardiovascular health and longevity research, I’m especially looking forward to his perspective on what the science actually supports versus the hype. a.co/d/09jhNj0s
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PHOTON-COUNTING CT: THE BEST IMAGES ARE NOT THE PRETTIEST. THEY ARE THE ONES YOU CAN TRUST. After five years of using Photon-Counting CT (PCCT) in clinical practice, one thing has become increasingly clear to me. Beyond the extraordinary temporal resolution of Dual-Source CT (66 ms, true hardware-based), what really changed the game was the combination of unprecedented spatial resolution, contrast resolution, and remarkably low image noise. We can visualize tiny anatomical structures, reduce artifacts from stents and calcifications, and characterize coronary atherosclerosis with remarkable detail. But the real breakthrough is not simply better images. IT IS GREATER DIAGNOSTIC CONFIDENCE. When assessing a left main coronary stent, I dont simply want an image suggesting everything is fine. I want the highest possible confidence that everything IS fine. Yet I still hear colleagues asking: Nice images, but whats the clinical impact? Well, heres the point: IMAGE QUALITY IS NOT COSMETIC. DIAGNOSTIC CONFIDENCE IS NOT A LUXURY. DIAGNOSTIC UNCERTAINTY IS NOT HARMLESS. Uncertainty means potentially unnecessary examinations, invasive procedures, diagnostic delays, additional costs, patient anxiety, and sometimes inappropriate clinical decisions. And the safest examination is not necessarily the one with the lowest radiation dose. It is the one providing a reliable answer with the lowest reasonable overall burden to the patient. Of course, better images dont automatically guarantee better outcomes. But better anatomical information, when correctly interpreted, can translate into more accurate diagnoses and better clinical decisions. We need to move beyond pixels and spectacular images and start discussing diagnostic certainty, reproducibility, downstream testing, and patient safety. Because the real question is not simply: Can we make the diagnosis? It is How accurately, how confidently, and at what overall cost to the patient? THE REAL PRODUCT OF DIAGNOSTIC IMAGING IS NOT AN IMAGE. IT IS A CLINICALLY ACTIONABLE ANSWER. #PhotonCountingCT #CardiacCT #DiagnosticConfidence #PatientSafety #CardiovascularImaging
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Steve Kaplan retweeted
In 1957, a Russian immigrant published a novel of more than a thousand pages built around one question: what happens if the people who make the world run simply stop? Its title is Atlas Shrugged. In France it's called La Grève, The Strike. It wasn't even translated into French until 2011. That tells you something. This morning, I think Elon Musk wrote the sequel. A. Where the book comes from. Ayn Rand was born Alisa Rosenbaum in Saint Petersburg in 1905. As a teenager, she watched Bolshevik soldiers walk into her father's pharmacy and seize it in the name of the people. Her family lost everything. Not to a competitor. To a committee. She fled to America in 1926 and spent the rest of her life writing about one distinction: those who create, and those who seize. B. The story. In Atlas Shrugged, America is sliding into decline. Not because of war. Because of rules. Year after year, a growing class of bureaucrats, regulators and planners decides that production must be controlled, shared "fairly," frozen. They never build anything. They issue directives. The worst one freezes every worker in his job and forces every inventor to hand over his patents for the public good. And one by one, the people who make the country run start disappearing. The best engineers. The industrialists. The inventors. An oil man sets his own wells on fire before vanishing. The whole country keeps repeating a question it doesn't understand: "Who is John Galt?" John Galt is the man behind the disappearances. He has convinced the creators to go on strike. They withdraw to a hidden valley in the Colorado mountains, where everyone keeps what they make and trades freely. And they let the world find out what it looks like without them. The lights go out in New York. The grey men are left alone with their directives, and discover that a directive has never produced a single kilowatt. C. The core idea. The strike isn't about money. It's about consent. Rand's insight is that the system that captures the creators runs on their cooperation. It needs them to keep producing so it has something to redistribute. The bureaucrat is a parasite who needs a host. Remove the host, and he's exposed as what he always was: useless. D. What Musk just did. This morning, Musk announced that next year he will give one of his own SpaceX shares to every kid in America. "The first of many." Here's what's fascinating. It's the strike, run in reverse. Rand's creators withdrew. Musk stays. He keeps building rockets, satellites, AI. But instead of walking away from the system, he walks around it. The value goes straight from the builder to the citizen. No ministry, no agency, no committee in the middle. Rand had to make the creators disappear to prove the bureaucrats were useless. Musk doesn't need to disappear. He just needs to stop routing value through them. Same result. The grey men are left standing in the middle of a pipe nobody uses anymore. E. The difference that changes everything. Rand's strike has a flaw her critics never stopped pointing out: ordinary people are left behind. The creators retreat to their valley. The rest of the country sits in the dark. Musk's version fixes that. He isn't taking the creators out of the world. He's bringing the world into the valley. Every kid in America becomes a shareholder in the machine. Not a spectator of the strike. A participant. That's the alliance being formed right now: builders and citizens, directly, with nothing in between. And the only people who lose that deal are the ones who never built anything. F. Why now, and not in 1957. In Rand's time, the strike was a fantasy. You couldn't produce at scale without the state's permission, and you couldn't reach every citizen without its pipes. In 2026, one founder can build rockets, run a global network from orbit, and pledge equity to 73 million children in a single post. AI will soon do in seconds what a ministry does in years. The tools of the strike finally exist. And they don't require anyone to leave. G. The ending. For seventy years, "Who is John Galt?" was a shrug. A way of saying nothing can be done. In the book, the strike ends when the creators decide the road is clear and walk back into the world to rebuild it. That's the scene we're watching. Not a man leaving. A man coming back, with a gift for every child. The grey men are about to discover what Rand promised them seventy years ago: a world that no longer needs them.
I don't know if you realize what just happened. Elon Musk is completely bypassing the State. For 100 years, we've been told the problem is capital. That it must be captured, taxed, redistributed. With an army of intermediaries standing between those who create wealth and the people: ministries, agencies, commissions, bureaucrats. Musk is doing the opposite. He's taking his capital and giving it directly to the people. One SpaceX share to every kid in America. Not a handout. Not a subsidy. A piece of the machine that's taking humanity to Mars. And he says it himself: this is the first of many. Mises understood this back in 1944: the bureaucrat creates nothing. He administers what others created, following rules that have no connection to the value produced. The day value flows directly from the one who creates it to the one who receives it, the bureaucrat has no function left. That's what's being born right now. A new liberal world order, where the very concept of the State will make less and less sense. The world we're entering is a world of abundance. AI, robots, energy, space. And that abundance won't come through the State, for one simple reason: we have a century of proof that it doesn't work. Redistribution was version 1.0. Direct distribution of capital is 2.0. While France is still debating how to tax builders even more, America is handing stock to its kids. Pick your side.
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Steve Kaplan retweeted
Chapter 2 of my lipid tutorial series is now up at Substack. Enjoy my free discourse on Fatty Acids, preferably after you read Chapter 1 published a few days ago. Many more chapters to follow. Please consider signing up. thomasdayspring.substack.com… @nationallipid @foundationofnla @society_eas @ASPCardio @escardio @atherosociety @FamilyHeartFdn @fhpatienteurope @TheEndoSociety
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I resisted medications most of my life. Then Piper, my 5-lb Chihuahua, changed my thinking. Now, on a statin, ezetimibe & Repatha: LDL-C 21, ApoB 39. Read a free chapter from my upcoming book, The Stents I Didn’t Get: heartceo.ai/sample-chapter/
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Thank you, @FCademartiri, for your generosity with your time and patience with my endless questions! It was a pleasure finally meeting you in person and learning so much about photon-counting CT and heart health.
Questo è un mio nuovo paziente: Steve Kaplan @ROIdude Ci siamo conosciuti online nel mezzo delle mie discussioni su TAC del Cuore e Photon Counting CT. Ha appena finito di scrivere un libro che a breve sarà disponibile online e su Amazon da Ottobre e dove parla anche di me. Ora si può già pre-ordinare l'audio book: amazon.com/dp/B0HHTJLGRJ?lv=…, Naturalmente il libro e l'AudioBook sono in inglese. Il libro parla della sua storia e delle sue coronarie con una immersione in questo mondo da paziente che voleva capire e risolvere un problema importante che hanno moltissimi altri pazienti. E' venuto dalla West Coast degli Stati Uniti a Milano al Centro Diagnostico Italiano per risolvere un quesito importante e difficile sulle sue coronarie per completare il suo percorso e vedere se le sue intuizioni erano corrette. Ovviamente con la tecnologia Photon Counting ❤️. Il Libro si intitola: "The Stents I didn't Get" (Gli stent che non mi sono messo) e già da qui si può intuire in che area si sviluppa la sua storia. In seguito vi racconterò/racconteremo più dettagli. Stay Tuned.
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Steve Kaplan retweeted
Every anti-inflammatory drug tested for heart disease has failed. Steroids. NSAIDs. Canakinumab. Colchicine. Ziltivekimab. All of them, either no benefit or outright harm. Meanwhile every single way you lower LDL, statins, fiber, diet, anything, reduces plaque. Proportional to the LDL drop. Every time. Inflammation doesn't start atherosclerosis. It shows up after LDL particles get stuck in the artery wall and refuse to leave. We've been treating the smoke and ignoring the fire for decades.
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A cyclist was told he had “the heart of a 20-year-old.” Six weeks later, he died of a heart attack. Over dinner in Milan before my PCCT scan, @FCademartiri raised a possibility: his earlier chest pain and troponin rise may already have signaled a small heart attack.
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LA TAC A CONTEGGIO DI FOTONI (PHOTON COUNTING CT) E LE SUE RICADUTE PRATICHE IN CARDIOLOGIA Da 30 anni mi occupo di TAC del Cuore. Siamo entrati nel 5° anno di applicazione della tecnologia TAC a Conteggio di Fotoni. La "Killer Application" è senza dubbio la valutazione del Cuore e delle Arterie Coronarie. Come forse sapete già l'Aterosclerosi Coronarica è la 1^ causa di diasabilità e morte nei paesi occidentali. Quindi da un lato è la malattia che pesa di più in termini di complicanze e conseguenze sulla popolazione, dall'altro è anche la malattia meno coperta da programmi di prevenzione ad ampio spettro. Ed è un peccato perché si tratta di una malattia cronica (su base degenerativa, infiammatoria, metabolica, immunomediata,...) che è possibile frenare in modo importante, anche completamente. Specialmente oggi che le opzioni preventive (comportamentali, dietetiche e terapeutiche) sono così avanzate e sviluppate. Il problema storico è che ci siamo sempre affidati, in mancanza di meglio, alla stratificazione di popolazione basata sui fattori di rischio cardiovascolari (età, sesso, colesterolo, pressione, glicemia/diabete, familiarità, fumo, obesità, assenza di attività fisica,...). Purtroppo questo tipo di approccio non consente di derivare realmente un rischio per il singolo individuo, in alcun modo. E' un calcolo che assimila l'individuo/paziente seduto davanti al suo medico in ambulatorio ad una popolazione di pazienti simili a lui per quello che riguarda i fattori di rischio. Ora però siamo entrati in una fase nella quale possiamo realmente individualizzare e personalizzare il livello di aggressività della prevenzione cardiovascolare sul singolo paziente. Questa strategia prevede che si valuti accuratamente la presenza e la tipologia di aterosclerosi coronarica con una risoluzione spaziale di 100 micron (0.1mm), in modo da sviluppare insieme ai Cardiologi, ai Medici curanti, ai Medici dello sport, e a tutti gli specialisti di riferimento del paziente, per poter rallentare/fermare la progressione della malattia ed evitare le conseguenze catastrofiche che può avere. Attenzione, questo non significa che i fattori di rischio non siano fondamentali; diventano piuttosto in quest'ottica dei target per modulare le terapie nel tempo. La corretta gestione medica di questo percorso va fatta insieme al proprio Medico di fiducia. Da pioniere della TAC del Cuore e della TAC a conteggio di fotoni ho investito tutta la mia carriera professionale per arrivare a questo punto; ora possiamo realmente fare la differenza in questo settore dove ancora troppi subiscono danni di salute evitabili. Dr. Filippo Cademartiri Esperto di Photon Counting CT presso: - Centro Diagnostico Italiano, via Saint Bon, Milano - SYNLAB SDN, via Gianturco, Napoli
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I’m a competent adult. Why do I need X when I own a perfectly good megaphone?
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Replying to @drterrysimpson
Amazing that Mark still pushes the “endothelial damage must come first, then LDL enters” hypothesis. ApoB particles don’t need a pre-damaged endothelial wall to enter and become retained. If your entire model depends on that premise, you have a problem.
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@NutritionMadeS3 Appreciate the support. I actually recommend people follow you in my upcoming book, out 10/28. If you’d be interested, I’d be happy to send you a review copy—I’d genuinely value your thoughts.
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I’m just glad I didn’t name my company LowCarbDirect or something that would pigeon hole me into a fringe scientific concept. Building an entire brand around a fringe scientific theory especially dietary isn’t a smart business decision. Iron DPC stands for the heavy metal weight that is lifted and everything that supports human performance and muscle and longevity. We have a gym with Iron weights, a sauna, and a cold plunge at the medical clinic for patients who are interested. The iron weights will never go out of fashion and will never be proven wrong. They never lie. They’re always heavy. They will always make you stronger.
Replying to @SomerwilTara
2/2 Dr. Hartmann is setting the ultimate example of professional integrity in the medical sphere. It takes a true clinician to put patient safety above an internet brand. Let’s push this forward so more practitioners follow his lead and protect future lives. Data wins.
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Just finished recording a podcast with Dr. @WarrickBishop and am incredibly grateful for the conversation. He combines deep cardiology expertise with a genuine commitment to helping patients understand the evidence and take a more active role in their own care.
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A useful list of prominent "LDL doesn't matter" voices. What interests me isn’t their motives, but their methodology: start with a conclusion, then find evidence that supports it while discounting the much larger body of evidence that doesn’t. That’s the opposite of a Bayesian approach.
The patient-media twelve: The white coats patients quote between visits and why ApoB is bad for their business. I had Grok analyze X and the youtubes and websites of these 12 influencers to learn how they generate revenue, their positions on LDL and apo B and if they even practice medicine. I followed these influencers for years and have either interacted with these "experts" or even had patients consult with them before I learned about their grift. I used to search for physicians online who would tell me I could ignore LDL. I have the physique. I am insulin sensitive. Triglycerides look great. I wanted the fantasy to be true. It was a good hypothesis. It has failed in front of me. Patients now walk in already subscribed. They are quoting a short list of doctors, a Harvard-Oxford YouTube channel, an engineer, and a fasting cardiologist with a million subscribers. Below is that list, what they actually sell, and the step that pays. This is a map of the library. It is not a claim that every person on it says “LDL never causes disease.” Some are more careful than others. Patients do not hear the asterisk. Jack Wolfson @DrJackWolfson— The Paleo Cardiologist, Natural Heart Doctor. Virtual protocols, coaches, supplements, Costa Rica based. Public line: statins fail, LDL is not the enemy. My clinic line is worse: a patient after a stroke told to stop his meds after paying the “natural heart doctor” $7,000. Aseem Malhotra @DrAseemMalhotra— A Statin-Free Life. The book in the waiting room. The message: we over-statin low-risk people. The problem? Cumulative apo B exposure over a lifetime generates the plaque. Most of these influencers ignore this and latch onto things like the PREVENT score that estimates risk in the next 5 years. Leap patients hear: I don’t need the pill. Philip Ovadia @ifixhearts— surgeon plus cash-pay metabolic practice. No clean public sticker. I had a patient who did a consult with him for a “carnivore diet” then offered again $7,000 in coaching. Thousands of dollars to hear eat-for-metabolic-health, then my patient went on for a triple bypass anway.📷 Tro Kalayjian @DoctorTro— Toward Health telemedicine. Real visits, CGM, advanced lipids. He professes “LDL is a lie.” He still sits in the neighborhood patients use as permission to stay diet-first as if avoiding carbs magically protects against heart disease based off small studies and cherry picked LMHR and keto case studies. I’ll grant him that he actually manages patients and carries medical liability for what he does. Unfortunately his rhetoric affects others and patients will believe him thanks to his MD and white coat and suffer the consequences later. But at least he manages some patients. The rest? Not so much. They sell views and supplements and courses and hide behind “not medical advice” disclaimers. The LMHR story Nick Norwitz @nicknorwitz— MD-PhD, 1.3 million on YouTube, paid newsletter. Public LDL 574 on keto. Patients hear phenotype = safety. He often says the long-term risk is unknown. That sentence is not what gets clipped. Dave Feldman @realDaveFeldman— engineer, not a physician. Named lean mass hyper-responder. Crowdfunded scans. Built the idea Norwitz scaled. Paul Saladino @CarnivoreMD— Heart & Soil organ supplements sells millions, Costa Rica house, psychiatry training. The diet is the SKU. “Maybe treat the ApoB” is a refund risk. Doesn’t carry liability and doesn’t manage patients. The ambient feed Ken Berry @KenDBerryMDand Anthony Chaffee @anthony_chaffee— short-form everywhere. Proper Human Diet / Plant-Free MD. Patients binge this between visits. No consult required. @SBakerMD Shawn Baker — Revero platform, carnivore athlete-surgeon brand. Meat-heals. That is a subscription machine, not the $8,000 MRI menu. Sean O’Mara @DrSeanOMara— publishes the luxury tier: $8,000 Alpha Start, $50,000 leadership protocol. If visceral fat falls on MRI, LDL becomes a footnote. Pradip Jamnadas. Orlando interventional cardiologist who still puts stents in. YouTube product is fasting. Patients use the lecture to delay the medicine he would still use in the lab. These twelve make money selling the LDL and apo B don’t matter grift. Conservaties are more at risk for this grift. Scorned during the scamdemic with lockdowns and vaccine mandates, the distrust for authority and pharma is highest among the Right. The diet often works on what they can feel: weight, glucose, triglycerides, reflux, energy. Those improvements are real. The sale is the next sentence: therefore ApoB can wait. Statin fear is pre-loaded. Muscle aches, an uncle who infarcted on Lipitor, a Malhotra clip, institutional distrust. A cardiologist saying “don’t start it” is a relief purchase. Then identity. Leaving the tribe means the physique was not immunity. I know that sentence because I lived it. What is true, and the step that is not Metabolic disease is neglected. Ultra-processed food is a disaster. The keto/carnis have willfully misinterpreted the data and latched onto the 5 year PREVENT score and studies that run 5 years on a drug that lowers lipids showing minimal decrease in mortality. The reality? People aren’t a 5 year study. Apo B exposure is a lifetime of risk. Plaque builds over 50 years. Apo B doesn’t care if I have visible abs (which I do). Lean people on keto really can run LDL into the 300s–500s with high HDL and low triglycerides. Visceral fat is a real risk marker. Fasting can lower insulin.None of that makes ApoB optional. ApoB-containing particles cause atherosclerosis. Familial hypercholesterolemia. Mendelian randomization. Statins, ezetimibe, PCSK9 inhibitors. Same direction every time particle number falls. “LDL only matters if small and dense” is false. “If insulin is low, ApoB cannot deposit” is false. I used to believe the second one. I checked. It did not hold. LMHR is a phenotype, not a shield. “We lack a 30-year carnivore RCT” is true. “Therefore do not treat a causal risk factor” is not how you practice after you have watched plaque declare itself. A calcium score of zero in a 35-year-old is not clearance. Soft plaque exists. Time exposure under the curve of apo B matters. Secondary prevention is not a podcast topic. After a stroke or an infarct, stopping proven therapy is not root-cause courage. It is preventable recurrence. If the product is eat more meat, skip the statin, buy the consult, or subscribe to the letter, treating ApoB makes the product look unnecessary. They are rarely the physician of record when someone gets an MI or CVA. Bios say educational content only. The house is in Costa Rica. The surgery is locums. The complication lands in a shop like mine. What I tell the patient? You can keep the meat. You can keep the fasting window. You can chase visceral fat. You can refuse a statin and use ezetimibe or a PCSK9 if the fear is the drug class. You cannot buy an exemption from particle-years with a white coat on YouTube. I wanted that exemption. I looked for the same twelve. The data in the chair in front of me did not care what I wanted.
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New York City's mayor, Zohran Mamdani, wants the city to open its own grocery stores. Mamdani thinks he can run grocery stores better than Kroger. We analyze companies for a living, and grocery is one of the most difficult businesses in the world. Unless it's canned food, your inventory goes bad. These companies run on 2% or 3% margins. The only way the government can run grocery stores better is with huge subsidies. At the end of the day, it's going to cost taxpayers so much more. They should have just sent $100 checks to poor people. A check lets people buy food anywhere, and it doesn't put the store down the street out of business. That would have done so much better, and there would be no competition issues.
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