@Tim_Lohoff

Life Science Venture Capitalist @ForbionLifeSci | Ph.D. in Stem Cell Biology & Medicine from @Cambridge_Uni @ReikLab

 Munich, Bavaria
Joined February 2017
  • Tweets93
  • Following443
  • Followers259
5Media
New preprint! 🚨@KeckMedicineUSC @uzh_irem We started with the simple question: What happens when we transplant stem cells into a mouse model of #stroke, and what are the interactions between graft and host? Took us only 5 yrs to find out😀: biorxiv.org/content/10.1101/… 1/10 🧵
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Tim Lohoff retweeted
Reik Lab@ReikLab12 Jan 2023
New preprint! 🥳 biorxiv.org/content/10.1101/… Led by @AledJohnParry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency. Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1. 🧵👇

Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory...

Epigenetic mechanisms govern developmental cell fate decisions, but how DNA methylation coordinates with chromatin structure and three-dimensional DNA folding to enact cell-type specific gene...

biorxiv.org
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Happy to see another piece of my PhD work published in @GenomeBiology! 🥳 Amazing collaboration with @RArgelaguet and Stephen Clark 💪#DreamTeam Big thanks to everybody involved @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst! Finally, check out the great tweetorial below 👇:
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Great work @rust_ruslan and team! 🙌🐭
Ruslan Rust
@rust_ruslan1 Aug 2022
Preprint 🚨 How does immune suppression alter the molecular 🧬 and anatomical 🧠 roadmap of #stroke pathology? We detect distinct changes in different pharmacological and genetic immunodeficient models of stroked mice 🐭⚡️💉 Read more here: biorxiv.org/content/10.1101/… 🧵👇🏽 1/11

Molecular and anatomical roadmap of stroke pathology in immunodeficient mice

Background Stroke remains a leading cause of disability and death worldwide. It has become apparent that inflammation and immune mediators have a pre-dominant role in initial tissue damage and...

biorxiv.org
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Wow 🤯 Congratulations @felix_lansing and team 🎉 Amazing work. Looking forward to following the path of designer-recombinases towards the clinic 🩸💪🏼 Keep the exciting work up! 🍀 Check out the great tweetorial below 👇
Felix Lansing@felix_lansing20 Jan 2022
Our work just got published in @NatureComms. We developed a dual designer-recombinase system that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. 1/11 @BuchholzLab_TUD @TakebeLab @tudresden_de @Medizin_TUD rdcu.be/cFmeD
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Our work is out in @ScienceMagazine! Using integrated spatial genomics technology, we have extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex with a great team @LongCai_Lab @gc_yuan @swzheng29 #seqFISH science.org/doi/10.1126/scie…

Single-cell nuclear architecture across cell types in the mouse brain

Multimodal measurements in single cells in the brain reveal nuclear organization principles across cell types.

science.org
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Incredibly happy to share that our work, co-led with @Tim_Lohoff is now available online at @NatureBiotech 🎉 Feeling very grateful to everyone who was involved in this project 🙏 Explore the data here: marionilab.cruk.cam.ac.uk/Sp…
Nature Biotechnology
@NatureBiotech7 Sep 2021
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis go.nature.com/3DRM6rY
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Tim Lohoff retweeted
Reik Lab@ReikLab7 Sep 2021
Paper alert! 🎉 By combining SeqFISH and scRNA-seq data we've generated a spatially-resolved map of cell types and gene expression in the early mouse embryo. doi.org/10.1038/s41587-021-0…
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Cai Lab@LongCai_Lab7 Sep 2021
Our work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out at @NatureBiotech ! Congratulations to all the authors! nature.com/articles/s41587-0… #seqfish #spatial #singlecell #transcriptomics

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

Nature Biotechnology - Improved integration of spatial and single-cell transcriptomic data provides insights into mouse development.

nature.com
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Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis go.nature.com/3DRM6rY
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Impressive and important work 🐭 Congratulations to @rust_ruslan and all other authors! 🤩🥳 check it out 👏💥
Ruslan Rust
@rust_ruslan12 Aug 2021
Preprint alert!🚨 We as neuroscientists highly depend on behavioral testing in rodents 🐭. Still, assessing motor function or recovery can be so challenging⚡️. We aimed to change that using #deeplearning @DeepLabCut assisted 3D behavioral profiling biorxiv.org/content/10.1101/… 🧵1/
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Happy to share our latest preprint for imaging-based single-cell multimodal measurements to understand nuclear architecture in mouse brain cortex! Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architecture biorxiv.org/content/10.1101/…

Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architec...

Nuclear architecture in tissues can arise from cell-type specific organization of nuclear bodies, chromatin states and chromosome structures. However, the lack of genome-wide measurements to interr...

biorxiv.org
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We are delighted to announce that Professor Wolf Reik has been appointed Director of the Babraham Institute, following an open and international search. Read the full announcement here: ow.ly/mXhb50E8930
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Tim Lohoff retweeted
Reik Lab@ReikLab11 Mar 2021
Job alert! We're looking for three postdoctoral researchers to lead exciting projects investigating the #epigenetic regulation underlying lineage specification during #development. Apply here: babrahaminstitute.livevacanc… #academicjobs @IHEC_Epigenomes
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Did you ever wonder if there are any biomarker for brain injuries 🧠? Read the nice commentary from the talented @rust_ruslan to learn more!👇🔬🙂
Ruslan Rust
@rust_ruslan10 Feb 2021
Many of us have heard about #biomarker - But why are they so tremendously important to manage a brain injury? Have a look at my recent commentary in @_JCBFM about the recent developments of promising new blood biomarker for stroke. 1/6 👇🧠🤕 journals.sagepub.com/doi/ful…
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Really excited to share our paper on @NatureGenet about the impact of mitochondrial metabolism on nuclear DNA methylation. Thanks to @ERC_Research ,@ArmeniseHarvard, @Telethonitalia, @UniPadova for the amazing support. go.nature.com/39CU7Ur

Metabolic control of DNA methylation in naive pluripotent cells

Nature Genetics - Stat3 depletion in pluripotent cells decreases α-ketoglutarate and increases the expression of Otx2 and its targets Dnmt3a and Dnmt3b, leading to global DNA hypermethylation.

nature.com
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Tim Lohoff retweeted
Cai Lab@LongCai_Lab27 Jan 2021
Check out our latest work of DNA seqFISH+ now published @nature nature.com/articles/s41586-0…
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BetzLab@BetzLab18 Jan 2021
You wanna build muscles? 💪🏼 At least in vitro we know how 😉 Check out our latest paper @eLife investigating forces during muscle development! Huge shout out to @GilbertLab and @JoergEnderlein for making it so beautiful! elifesciences.org/articles/6…
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E8.5 seqFISH data from @Tim_Lohoff/@shazanfar/@LongCai_Lab is on MouseGastrulationData devel now! Count matrices, annotation, spot locations, cell segmentation masks, imputed Tx-wide counts - the whole shebang. Give it a go for methods work or dev bio! bioconductor.org/packages/de…
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Congratulations @Diljeet_Gill @aledjohnparry and all other authors 🥳. One of the most exciting projects from the lab showing that transient reprogramming leads to rejuvenation of human fibroblast! Check out the preprint 👇:
Reik Lab@ReikLab18 Jan 2021
Preprint alert! 🎉 By expressing the Yamanaka factors until the maturation phase of iPSC reprogramming and then withdrawing them, we were able to rejuvenate human cells (many features suggest by ~30 years!) whilst retaining their initial cell identity. biorxiv.org/content/10.1101/…

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue dysfunction and disease. At the cellular level, ageing is associated with reduced function, altered gene...

biorxiv.org
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