@TulpuleLab

Pediatric oncologist and Physician-Scientist at MSKCC. Receptor tyrosine kinase (RTK) fusions and condensates in cancer. DNA repair. Pediatric sarcomas.

 Memorial Sloan Kettering
tulpulelab.net/
Joined April 2021
  • Tweets122
  • Following739
  • Followers667
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without a hint of irony...
nature
@Nature17 Mar 2025
It can be hard to say no to service requests in academia. We sought advice on how to ensure researchers don’t get stuck doing unpaid labour go.nature.com/4bUX6WN

I spent two years organizing an international conference. How do I get compensated for my work?

Nature - It can be hard to say no to service requests in academia. Nature’s Careers team sought advice on how to ensure researchers don’t get stuck doing unpaid labour.

nature.com
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Tulpule Lab retweeted
jobRxiv
@jobRxiv8 Mar 2025
The Tulpule Lab is looking for research technicians. Come spend a few years in New York City and help advance pediatric cancer research! Research Technician in NYC @TulpuleLab Memorial Sloan Kettering Cancer Center See the full job description on jobR... jobrxiv.org/job/memorial-slo…

Research Technician in NYC

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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Tulpule Lab retweeted
jobRxiv
@jobRxiv13 Feb 2025
Postdoctoral Fellow - Cancer Research at MSKCC @TulpuleLab The Tulpule lab at MSKCC is seeking postdocs to study pediatric cancer, biomolecular condensates, and DNA repair. To read the full job description and apply, see link in the thread! #cancer_biology #cell_signaling #...
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New NYE tradition with @kirstin_chen! Afternoon drinks, home by sunset.
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Replying to @TulpuleLab @UCSF @MSKCancerCenter @Shruti_menon09 @DmGracilla33811
Interested in pediatric cancer and DNA repair? We are recruiting PhD students and postdocs, so please reach out and come join us in NYC. #MSKKids
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We would love to hear feedback, opportunities for new directions and collaborations. This is the work of many at @UCSF and @MSKCancerCenter, but led by 2 super star postdocs @Shruti_menon09 and @DmGracilla33811.
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3. Cell-line and PDX testing of the ATR inhibitor elimusertib as a synthetic lethal therapeutic strategy to target ATM defects across the class of FET rearranged tumors.
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2. New mechanistic studies of the interaction/competition between EWSR1-FLI1 (the Ewing fusion) and native FET proteins (i.e., EWSR1) at DNA double-strand breaks.
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1. Direct comparison of EWSR1-FLI1’s suppressive effects on ATM activation/signaling with loss of canonical ATM activators to benchmark the effect size and demonstrate the biological significance of the (partial) ATM defects we report here.
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We posted a BIG update to our study on Ewing sarcoma and other FET fusion-driven cancers. FET fusion oncoproteins are aberrantly recruited to DNA breaks and cause ATM defects, which can be targeted with the ATR inhibitor elimusertib. Updates include: biorxiv.org/content/10.1101/…

FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer

While oncogenes promote cancer cell growth, unrestrained proliferation represents a significant stressor to cellular homeostasis networks such as the DNA damage response (DDR). To enable oncogene...

biorxiv.org
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3. Cell-line and PDX testing of the ATR inhibitor elimusertib as a synthetic lethal therapeutic strategy to target ATM defects across the class of FET rearranged tumors.
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2. New mechanistic studies of the interaction/competition between EWSR1-FLI1 (the Ewing fusion) interaction with native FET proteins (i.e., EWSR1) at DNA double-strand breaks.
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1. Direct comparison of EWSR1-FLI1’s effects on ATM activation/signaling with loss of canonical ATM activators to benchmark the effect size and demonstrate the biological significance of the (partial) ATM defects we report here.
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Meet #MSKPostdoc Daniel Gracilla from the @TulpuleLab. Daniel is studying the role of FET and FET fusion proteins in altering DNA 🧬 damage response to elucidate the DNA Damage Repair vulnerability of Pediatric Sarcoma. 🇵🇭 #NPAW2024 #MSKKids
#BestPartOfScience: Using our imagination to further expand the explanation of biological and other scientific phenomena and unveil the secrets of nature. #CareerMotivation: To all hard-working postdocs out there, we need to keep going. Who knows, one of us may be on the verge of making another groundbreaking cancer treatment. Despite the challenges, we need to forge ahead. #BecomingAScientist: I wanted to blaze a new trail in which I can contribute to ensuring the health of the world. Back in grade school, I had been fascinated with biological things like how our heart beats, how our eyes can see, how a bird can fly, and even how a fish can swim. That propelled me to pursue a scientific career. Daniel Gracilla, PhD Tulpule Lab

ALT #BestPartOfScience: Using our imagination to further expand the explanation of biological and other scientific phenomena and unveil the secrets of nature. #CareerMotivation: To all hard-working postdocs out there, we need to keep going. Who knows, one of us may be on the verge of making another groundbreaking cancer treatment. Despite the challenges, we need to forge ahead. #BecomingAScientist: I wanted to blaze a new trail in which I can contribute to ensuring the health of the world. Back in grade school, I had been fascinated with biological things like how our heart beats, how our eyes can see, how a bird can fly, and even how a fish can swim. That propelled me to pursue a scientific career. Daniel Gracilla, PhD Tulpule Lab

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Replying to @oleg8r
Happy birthday 🔥
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Moved to NYC, started a new job, rebuilt a lab, learned to tie a bowtie.
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Replying to @kriwacki @BivonaTrever @CellCellPress
Thanks for the shout-out @kriwacki! Excited about your work and this focus on fusion oncoproteins, especially in #ChildhoodCancer
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Tulpule Lab retweeted
Anton Henssen@anton_gh11 Jul 2023
33 fully funded PhD positions are available this autumn for people interested in studying the devastating childhood tumor neuroblastoma in Berlin (Charité, MDC), Heidelberg (DKFZ) or Cologne. Please share with your students. nature.com/naturecareers/job…

33 doctoral positions (PhD track, E13) - Berlin (DE)

The Neuroblastoma Evolution Integrated Research Training Group is currently accepting applications for

nature.com
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Replying to @KlebanoffLab
Lived up to the hype! The yuba sandwich with broccoli rabe was 🔥
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