Co-Founder & CEO of women’s health diagnostics Co | ex- VP @Tally_health, ex-858tx, ex- @Genentech & @GSK | PhD @UCSF | MBA @MITSloan. 🧬 🌌 🔭
Princeton, NJ
Joined May 2014
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I don’t go on X much these days, but I just re-secured my account! Apologies for any strange posts! I was hacked!
Dr. Trinna L. Cuellar retweeted
More passion!☀️
More passion!☀️
More energy!💥
More energy!💥
Another M8.8-class flare just erupted from the Sun!
Here’s SDO’s view:
I am thrilled to share our new open-access paper on the non-invasive epigenetic age clock we built with over 8k diverse volunteers and that inspired our commercial non-invasive epigenetic age test @tally_health. @GeroScienceAGE #openaccess #aging #epigeneticagetest #methylation
📢New Open🔓Access Paper
CheekAge: a next-generation buccal epigenetic aging clock associated with lifestyle and health by Maxim N. Shokhirev et al.
link.springer.com/article/10…
#epigeneticage #healthylife #agingclock #ensemblelearning #machinelearning
#simulatedannealing @dancingRNA @tally_health
Dr. Trinna L. Cuellar retweeted
A paper in @NatureElectron reports a hybrid computing system, called Brainoware, consisting of electronic hardware and a brain organoid, which can perform tasks such as speech recognition and nonlinear equation prediction. go.nature.com/489OoRu
ALT This is figure 1, which shows Brainoware with unsupervised learning for AI computing.
Dr. Trinna L. Cuellar retweeted
Isoleucine is an essential amino acid which, in excess, counters the health benefits of the mTOR longevity pathway. The @LammingLab is reporting that an isoleucine-restricted diet extends the lifespan of mice by 33% 👏 @Cell_Metabolism
Dr. Trinna L. Cuellar retweeted
Glycine may prolong life by inducing autophagy and mimicking methionine restriction. sciencedirect.com/science/ar…
Dr. Trinna L. Cuellar retweeted
Factors that accelerate epigenetic aging:
1. Smoking (worst)
2. Alcohol intake
3. Waist size
4. Body fat
5. CRP (inflammation)
6. Triglycerides
7. Childhood obesity
8. Type 2 diabetes
(Alcohol is turning out to be more toxic than we thought. Sorry) academic.oup.com/biomedgeron…
Beyond excited to see this out. New paper from the Sinclair lab: “Loss of #epigenetic information as a cause of mammalian aging”. A culmination of many years of work. Suggesting #aging is a “software” problem that is treatable! @davidasinclair cell.com/cell/fulltext/S0092…
Dr. Trinna L. Cuellar retweeted
Delighted to share our latest study that tests The Information Theory of Aging. 13 years of work. Available at 11 AM EST today @CellCellPress. What’s it about? Here’s a clue from Catherine Delphia’s illustration in Lifespan
I am so excited to see this work from the Frost lab! Congratulations!!! #RNA #neuroinflammation #Aging #Neurodegeneration #dsRNAs
New Frost lab paper alert:
#Tau!
#Retrotransposons!
#Neuroinflammatory double stranded RNAs!
science.org/doi/10.1126/scia…
@elizabethmochoa
@PaulRamirez42
@jimrayNDC
@UTHealthBarshop
@UTHealthSA
1/9
Dr. Trinna L. Cuellar retweeted
New Frost lab paper alert:
#Tau!
#Retrotransposons!
#Neuroinflammatory double stranded RNAs!
science.org/doi/10.1126/scia…
@elizabethmochoa
@PaulRamirez42
@jimrayNDC
@UTHealthBarshop
@UTHealthSA
1/9
Dr. Trinna L. Cuellar retweeted
Nice one @EricVerdin and team. Protection by NMN from the damaging effects of chemo 🐁🫀💪👏 @BuckInstitute mdpi.com/2073-4409/12/1/108
Congrats, @patrick_griffN! Excellent work! #epigeneticclocks #healthspan #costeffiencientagingclocks #aging #TIME-seq
We've updated our TIME-Seq preprint! 🚨 New: Improved human blood clock in 1000+ people ages 18-103. 3 mouse clocks, 4 interventions, & cell culture in 1600+ samples. Shallow TIME-Seq with scAge ($1.5/sample) in 250+ humans #aging #clocks @davidasinclair biorxiv.org/content/10.1101/…
So proud of my group!!! Check out our latest paper @tally_health. A little teaser. Much more to come.
#epigenetics #epigeneticclocks #healthspan #lifespan #aging
Our second peer-reviewed study "A set of common buccal CpGs that predict #epigeneticage and associate with #lifespanregulatinggenes" is published @Cellpress! bit.ly/3EhePsv Authors: Adiv Johnson, Maxim Shokhirev, @nicoletorosin, @dancingRNA #TallyHealth #WelcomeToANewAge
So grateful to be a part of this team @tally_health. More coming soon!
@melanie_goldey @patrick_griffN @davidasinclair @nicoletorosin #healthspan
#longevity #healthspan #ageisjustanumber #epigenetics
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Dr. Trinna L. Cuellar retweeted
Ovarian aging predicts aging rates in other tissues. Women reaching menopause before 40 are 2x as likely to die early than those reaching it between 50-54. Reversing ovarian aging may help reverse overall aging. In mice we’ve done it. Let’s give women the option ⬇️
Dr. Trinna L. Cuellar retweeted
Reducing the levels of epigenome-altering RNA from selfish genetic elements called LINE-1s, reverses DNA methylation age and extends the lifespan of prematurely aging mice. Could this be a way to reverse normal aging? science.org/doi/10.1126/scit…
Dr. Trinna L. Cuellar retweeted
New drug reduces symptoms in 2 mouse models of Alzheimer’s by turning up trash recycling, a process that sustains stem cells & extends mouse lifespan. Drs Ana Maria Cuervo & Evris Gavathiotis @EinsteinMed are preparing for human trials @lifebiosciences 👏 tinyurl.com/mwe9a9sw
Dr. Trinna L. Cuellar retweeted
What is consciousness? New research in epileptics with electrodes planted deep in the brain shows that we still hear sounds while asleep, but we don’t process the information because we’ve activated alpha-beta waves. So cool 😎 tinyurl.com/2p9xfj68
Dr. Trinna L. Cuellar retweeted
Our first peer-reviewed article "Human Age Reversal: Fact or Fiction?" is out in @AgingCell. Check it out here! bit.ly/3akokeg
@tally_health authors: @davidasinclair, @dancingRNA, Adiv Johnson, Maxim Shokhirev, @brad_w_e
#TallyHealth #WelcomeToANewAge #aging #healthspan
