Microbiologist 🧫 into biophysics, and 🤖. Glyxon Biolabs founder, DIYBio advocate. 🚀🏳️‍🌈🎨 Former ASU, Waseda, Osaka Univ., Max Planck, and UNAM researcher.

Mexico City MX
Joined March 2022
David J. Castillo-Cornejo PhD. 🔬 retweeted
Today I am sharing a new preprint and accompanying blog post. Hundreds of published papers include impossible western blots showing protein expression in cell lines that have deleted or mutated genes. These clumsy mistakes are widespread and repeated by LLMs.
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David J. Castillo-Cornejo PhD. 🔬 retweeted
Qué curioso que varios amigos y conocidos de CDMX me preguntaron dónde es aquí. Muchas veces tenemos cosas buenas cerca y no las conocemos. Los Dinamos, CDMX.
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Better than Marvel!
Ni escrita un año antes del rodaje, ni producido por las mejores compañías, ni dirigida por Stanley Kubrick; logras una escena épica como esta. No es ficción; pero el piano rodando ya es cine francés 😮‍💨🇫🇷
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David J. Castillo-Cornejo PhD. 🔬 retweeted
Ni escrita un año antes del rodaje, ni producido por las mejores compañías, ni dirigida por Stanley Kubrick; logras una escena épica como esta. No es ficción; pero el piano rodando ya es cine francés 😮‍💨🇫🇷
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David J. Castillo-Cornejo PhD. 🔬 retweeted
A Gaussian splat of a saffron flower. You can see it's three threads which are hand picked for the spice. Trained in @lichtfeldstudio #3dgs
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David J. Castillo-Cornejo PhD. 🔬 retweeted
🇲🇽 Una pequeña heladería-paletería del centro histórico de la #CDMX se ha convertido en destino de peregrinación gastronómica gracias a sus 🍨 helados con rostros de catrina que, impulsados por las redes sociales, congregan a capitalinos y visitantes de otros estados a pocas semanas del #DíaDeMuertos. #VideosLaJornada #heladosdecatrina #cdmx #centrohistorico #catrina
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David J. Castillo-Cornejo PhD. 🔬 retweeted
4335 aspirantes para 200 plazas. Llevamos décadas hacia esta tendencia. No hay salida laboral para una gran proporción de graduados de doctorado. Queda el subempleo o caer en la informalidad dentro del mismo sistema universitario (ej. prof. de asignatura). En el sector privado la
Hace un par de años, el @INAHmx sacó 67 plazas de investigador a "concurso abierto". Hace unos meses la @Secihti_Mx sacó 200. Se inscribieron casi cinco mil doctores. El resultado no se acercó al cinismo del INAH, pero fue aún más fraudulento por lo que ya estamos sabiendo. Y por una vez, copio un infograma del pasquín azul. xitter.cf/LectorHistoria/status/…
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Blade runner aztec edition
LLUVIA REVELÓ UN ESPECTÁCULO ÚNICO EN LA PIRÁMIDE DEL SOL. #TEOTIHUACAN Durante las lluvias más intensas, la Pirámide del Sol, en la zona arqueológica de Teotihuacán, se transforma en un impresionante sistema natural de escurrimientos. El agua fluye por sus cuatro caras y crea una imagen que cautiva a quienes logran presenciarla. Este comportamiento ha despertado el interés de especialistas, quienes consideran que podría no ser casual. Diversas investigaciones sugieren que el monumento habría tenido un vínculo simbólico con el agua y la fertilidad, elementos fundamentales en la cosmovisión teotihuacana. Aunque no existe una conclusión definitiva sobre su función ceremonial, algunas hipótesis relacionan a la Pirámide del Sol con deidades del agua como Tláloc y Chalchiuhtlicue, lo que refuerza la importancia que este recurso tenía para una de las civilizaciones más influyentes de Mesoamérica. Visitantes y arqueólogos coinciden en que el fenómeno, visible solo en temporada de lluvias fuertes, ofrece una perspectiva distinta del monumento y de su posible relación con los ciclos agrícolas y rituales del agua. #TheWeb #ElMensajero
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David J. Castillo-Cornejo PhD. 🔬 retweeted
Me llega la obra de uno de los top mundiales en filosofía de la IA, el gran Luciano Florido. Expectativas altas, ya veremos.
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Sorry people... AI and biology isn't going anywhere if we still think living matter as a Laplacian clock.
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David J. Castillo-Cornejo PhD. 🔬 retweeted
Emma's is the right take. The interesting question is not "can lab automation replace literally everything we do by hand?" The interesting question is "what new experiments can we perform with automation that could never be done by hand?" And for my money the best automation-only experiments are not going to be the ones that simply require lots of scale and replicates. I'm more curious about the way AI enables rapid real-time adjustment of experimental conditions in response to data. I want to see tight automation loops where an AI is making significant changes to the protocol 10 times a day. Not just changing the pipetting volumes on a few experimental inputs - totally refactoring a protocol the way that a human would.
Speaking as someone who spends most of their time building automation platforms and teaching people to do it (enough that I built a whole class around it)... but who also spent six years of my life splitting stem cells every 36 hours... I am split on this one. On one hand, @mkoeris is right that the primitives are learnable and that novel combinations are not some sacred skill. On the other, @hsalis is 💯 that the large majority of experiments are far from autonomous. Most methods that are truly automatable, I can still do way faster and probably better with a multichannel pipette, I just have better things to do with my time. Automating bespoke science is the hard part, but that is where the most exciting progress is to be made. I'd encourage all to challenge themselves to think beyond automating the mundane and ask what science simply could not be done in the absence of a robot: real time responsive feedback, or changing many parameters at once based on the data as it is generated. The kind of experiment where no amount of extra hands would ever get you there. We are only scratching the surface there. (Currently grading midterm proposals for my automation class at the moment. One aim has to justify a genuine *need* for automation, and any proposal that justifies it with throughput, combinations, scale, or time is a big yawn. Think bigger, people 🦾)
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Phage celebrations ...coming soon!
Every #WorldPhageDay - 22 October, we celebrate bacteriophages - the most abundant biological entities on Earth and a vital hope against antimicrobial resistance. This is your chance to host a talk, share research, run an event, or simply post about why phages matter. #LovePhage!
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David J. Castillo-Cornejo PhD. 🔬 retweeted
1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
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David J. Castillo-Cornejo PhD. 🔬 retweeted
If you missed the superb lecture last week by @ChristofferNorn, have no fear because you can check out the recording 👇 youtu.be/czkQXg0wwrw
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David J. Castillo-Cornejo PhD. 🔬 retweeted
Will AI replace healthcare professionals? Here is an AI robot on its first day working in a hospital after finding out that: • the EHR needs 17 clicks to order one test   • the medication list is different in three systems   • interoperability sometimes means making a phone call   • and fax machines are still critical infrastructure   What else? The video is obviously AI-made.
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David J. Castillo-Cornejo PhD. 🔬 retweeted
How do you build a telescope for particles that can pass straight through Earth? You turn a billion tonnes of Antarctic ice into the detector. IceCube, the observatory behind Francis Halzen’s Nobel-winning work, has 5,160 light sensors frozen deep beneath the South Pole. Spread through a cubic kilometre of ice, they wait for an encounter that almost never happens. Most neutrinos pass through unnoticed. Occasionally, one interacts with an atom, producing charged particles that race through the ice faster than light travels through ice. This does not break Einstein’s speed limit. Light slows down in ice. Those particles emit a faint glow called Cherenkov light. By measuring which sensors light up, when they do, and how much light they receive, researchers estimate the neutrino’s energy and arrival direction. The enormous detector gives these elusive particles more matter to interact with. The clear, deep ice lets their light reach the sensors. Because neutrinos have no electric charge, cosmic magnetic fields cannot bend their paths. Their arrival directions can help trace the distant environments that produced them. So, buried kilometres underground, IceCube watches the universe through tiny flashes in the dark. A marvel of modern science.
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David J. Castillo-Cornejo PhD. 🔬 retweeted
Quite right! #LovePhage! Celebrate #WorldPhageDay 22 October
Replying to @CTGvvon11
Trillions of them are on your skin and in your body right now waging a quiet war against bacteria that would otherwise grow out of control. They’re keeping you alive.
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