AI for science @PeriodicLabs | previously at Google DeepMind, TRI, Rivian, Berkeley Lab, Northwestern

Menlo Park, CA
Joined August 2018
We’re building the AI scientist. @PeriodicLabs is live! Super excited to be part of this journey.
Today, @ekindogus and I are excited to introduce @periodiclabs. Our goal is to create an AI scientist. Science works by conjecturing how the world might be, running experiments, and learning from the results. Intelligence is necessary, but not sufficient. New knowledge is created when ideas are found to be consistent with reality. And so, at Periodic, we are building AI scientists and the autonomous laboratories for them to operate. Until now, scientific AI advances have come from models trained on the internet. But despite its vastness — it’s still finite (estimates are ~10T text tokens where one English word may be 1-2 tokens). And in recent years the best frontier AI models have fully exhausted it. Researchers seek better use of this data, but as any scientist knows: though re-reading a textbook may give new insights, they eventually need to try their idea to see if it holds. Autonomous labs are central to our strategy. They provide huge amounts of high-quality data (each experiment can produce GBs of data!) that exists nowhere else. They generate valuable negative results which are seldom published. But most importantly, they give our AI scientists the tools to act. We’re starting in the physical sciences. Technological progress is limited by our ability to design the physical world. We’re starting here because experiments have high signal-to-noise and are (relatively) fast, physical simulations effectively model many systems, but more broadly, physics is a verifiable environment. AI has progressed fastest in domains with data and verifiable results - for example, in math and code. Here, nature is the RL environment. One of our goals is to discover superconductors that work at higher temperatures than today's materials. Significant advances could help us create next-generation transportation and build power grids with minimal losses. But this is just one example — if we can automate materials design, we have the potential to accelerate Moore’s Law, space travel, and nuclear fusion. We’re also working to deploy our solutions with industry. As an example, we're helping a semiconductor manufacturer that is facing issues with heat dissipation on their chips. We’re training custom agents for their engineers and researchers to make sense of their experimental data in order to iterate faster. Our founding team co-created ChatGPT, DeepMind’s GNoME, OpenAI’s Operator (now Agent), the neural attention mechanism, MatterGen; have scaled autonomous physics labs; and have contributed to some of the most important materials discoveries of the last decade. We’ve come together to scale up and reimagine how science is done. We’re fortunate to be backed by investors who share our vision, including @a16z who led our $300M round, as well as @Felicis, DST Global, NVentures (NVIDIA’s venture capital arm), @Accel and individuals including @JeffBezos , @eladgil , @ericschmidt, and @JeffDean. Their support will help us grow our team, scale our labs, and develop the first generation of AI scientists.
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Muratahan Aykol retweeted
If you are interested in working on science of scaling RL, please apply! You'll be closely working with me
I asked people which neolabs under $10B have the highest talent density: 32 votes: Core Automation (@MillionInt, @_arohan_) 26 votes: Periodic Labs (@LiamFedus, @ekindogus) 20 votes: Flapping Airplanes (@spectorb, @amspector100, @aidanmantine) 18 votes: Standard Intelligence (@G413N, @devanshpandey) 8 votes: Ricursive (@annadgoldie, @Azaliamirh) 5 votes each: - Ineffable (David Silver) - Mirendil (@bneyshabur, @HarshMeh1a, @shayan_, @tararezaeikh) - Recursive (@RichardSocher, @_rockt, @timshi_ai, @josh_tobin_, @CaimingXiong, @jeffclune, @tydsh, Alexey Dosovitskiy) 3 votes each: - Applied Compute (@ypatil125, @rhythmrg, @lindensli) - Isara (@ezhang7423, @hegasz) - Prime Intellect (@vincentweisser, @johannes_hage) 2 votes each: - Elorian (@AndrewDai, @yinfeiy, @SethInternet) - Goodfire (@eric_ho, @DanJBalsam, @banburismus_) - Inherent (@tantumscollins, @edwardfhughes, @LouisKirschAI, @kallyaleksiev) - Trajectory (@rronak_, @QuantumArjun, @MichaelElabd) - World Labs (@drfeifei, @jcjohnss, @BenMildenhall, @chlassner) People couldn't pick a company they work at or founded. Disclosure: I'm a small investor in Applied Compute, Factory, Standard Intelligence, Trajectory and Wafer. I didn't vote. Continued:
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Muratahan Aykol retweeted
Our co-founders @LiamFedus and @ekindogus sat down with @mariogabriele to discuss @periodiclabs, the limits of pure digital AI, and creating autonomous labs where nature is the RL environment.
"A system that can literally engineer matter is going to be of key importance to everybody." @LiamFedus and @ekindogus are the co-founders of @periodiclabs, a San Francisco-based startup building AI systems and autonomous laboratories to discover new materials, starting with a higher-temperature superconductor. Fedus previously helped build ChatGPT and ran post-training at OpenAI; Cubuk led materials and chemistry research at Google DeepMind. (3:14) What it takes to build a synthetic superintelligence (16:44) Dogus and Liam's path to AI (23:28) Lessons from launching ChatGPT (35:10) What AI learns across experiments (49:23) The difference in LLM performance on math vs. science (54:09) The competitive landscape (55:39) Final meditations
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Muratahan Aykol retweeted
"A system that can literally engineer matter is going to be of key importance to everybody." @LiamFedus and @ekindogus are the co-founders of @periodiclabs, a San Francisco-based startup building AI systems and autonomous laboratories to discover new materials, starting with a higher-temperature superconductor. Fedus previously helped build ChatGPT and ran post-training at OpenAI; Cubuk led materials and chemistry research at Google DeepMind. (3:14) What it takes to build a synthetic superintelligence (16:44) Dogus and Liam's path to AI (23:28) Lessons from launching ChatGPT (35:10) What AI learns across experiments (49:23) The difference in LLM performance on math vs. science (54:09) The competitive landscape (55:39) Final meditations
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Muratahan Aykol retweeted
Visited the lab - was struck both by how wide the search space is for materials synthesis experiments, and also how amenable it is to depth first search, where the design and informativeness of your next experiment improves as you pile up more data from previous runs.
We built high-throughput materials labs in Menlo Park to create a loop between experiments and models. The labs generate fresh data, the models learn from it, and then help us decide what to try next. Using only 1,300 H200s, plus months of our experimental data, we mid-trained and RL’d an open-source model to surpass GPT-6 Astra on our analysis benchmark. We call it Neon. This is real footage from our lab. We’re focusing first on hard problems in materials science, including superconductors, magnets, and semiconductor materials. Read our blog posts below.
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Muratahan Aykol retweeted
Neon required three pieces: the labs, the research, and the infra. It’s an early example of how our unique experimental data, combined with highly efficient infrastructure, can be used to train specialized scientific models with strong performance on relatively modest compute compared to frontier systems. Read more about our overall approach here. periodic.com/news/building-l…
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Muratahan Aykol retweeted
We built high-throughput materials labs in Menlo Park to create a loop between experiments and models. The labs generate fresh data, the models learn from it, and then help us decide what to try next. Using only 1,300 H200s, plus months of our experimental data, we mid-trained and RL’d an open-source model to surpass GPT-6 Astra on our analysis benchmark. We call it Neon. This is real footage from our lab. We’re focusing first on hard problems in materials science, including superconductors, magnets, and semiconductor materials. Read our blog posts below.
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Muratahan Aykol retweeted
Replying to @starsailing11
Good question! I tend to think that ML is the tide that lifts all ships, so we'll probably see a lot of things emerge. Obviously theoretical work is close to math, so probably the most straight forward (and iiuc the field is already seeing a lot of amazing results). Anything related to simulation is also quite low-hanging. Maybe improvements around quantum-simulation? There's been some really cool looking work there already. I'm also super bullish on automated labs like Periodic. So maybe there will be experimental results that happen sooner than we'd naively expect.
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Muratahan Aykol retweeted
Physics is a never-ending quest, and the ultimate proving ground for AI and RSI.
“I have come to think that physics is a never-ending quest.” Isaac Isidor Rabi discovered a method to measure the magnetic properties of atomic nuclei - research that would lead onto the development of MRI and atomic clocks. He was awarded the 1944 Nobel Prize in Physics.
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Muratahan Aykol retweeted
At Periodic, we love people with both science + LLM experience but would be very happy with folks who have: - strong science backgrounds - deep interest in AI tools - a desire to learn the rest (LLMs, evals etc) coding is getting easier, but doing science is not. we want to meet people with depth, accomplishments, and taste in science. if you have friends like this who want to work closer to AI, please send them our way. Also you get to work with people like Dima or yours truly
At @periodiclabs we are looking for brilliant new colleagues who excel at bridging AI and science. The role's main focus is advanced evals and training data/tasks. But you will also get involved in both internal science and AI work. Apply/spread the word! jobs.ashbyhq.com/periodic-la…
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At @periodiclabs we are looking for brilliant new colleagues who excel at bridging AI and science. The role's main focus is advanced evals and training data/tasks. But you will also get involved in both internal science and AI work. Apply/spread the word! jobs.ashbyhq.com/periodic-la…
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Muratahan Aykol retweeted
“The universe is too complex for any intelligence, human or AI, to make novel important discoveries without iterating with a lab.”
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Muratahan Aykol retweeted
As we ramped up our first lab at Periodic, we were surprised by how quickly we became intelligence-bottlenecked. The challenge shifted from conducting more experiments to understanding what we had actually made. @agarwl_’s talk gives a glimpse into the research + infra behind scaling high-compute RL on real experimental data. Early results suggest scientific analysis has nice scaling properties too.
I gave a talk at ICLR 2026 about how we are scaling RL on frontier LLMs with 1T+ parameters, on experimental data from our physical lab at Periodic! Here's a rough recording of the talk:
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Muratahan Aykol retweeted
this is probably one of the coolest roles we're hiring for rn apply below if you want to build the full stack of recursively self improving computers
Computation is physical: better materials → better chips → smarter models → better materials Periodic is hiring our first FDE to help close the loop. This role can be based in Taiwan. Apply here!
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Muratahan Aykol retweeted
Computation is physical: better materials → better chips → smarter models → better materials Periodic is hiring our first FDE to help close the loop. This role can be based in Taiwan. Apply here!
Replying to @periodiclabs
@periodiclabs is hiring the world's first Forward Deployed Engineer for LLM Systems of Atoms. You'll work closely with many top LLM systems engineers and researchers from the frontier labs — together with our semiconductor customers, to deploy and optimize frontier LLM systems in real industrial workflows. What we're looking for: 1. Hands-on experience with LLM system deployment and optimization 2. Passionate about optimizing the system end-to-end — from GPU kernels to orchestration 3. Good understanding of semiconductor processing ========================================= (We are open to hire from Taiwan too!) Periodic Labs 正在招聘全球首位 LLM Systems of Atoms 的 Forward Deployed Engineer。你將與許多來自前沿實驗室的優秀 LLM 系統工程師與研究員 — 以及我們的半導體客戶緊密合作,把前沿大模型系統真正部署並優化到工業級工作流程中。我們希望你具備: 1. LLM 系統部署與優化的實戰經驗 2. 熱衷於從 GPU kernel 到 orchestration 的端到端系統優化 3. 對半導體製程有良好理解 jobs.ashbyhq.com/periodic-la… Feel free to me / @LiamFedus / @kdelpaine directly if interested
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Muratahan Aykol retweeted
We’ve been busy! 👀👀
Industrial-scale science. Coming to a lab near you this summer.
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There’s a huge capability overhang in connecting today’s agents to high-throughput physical science labs Can’t wait to see what pops out once we close that loop
Industrial-scale science. Coming to a lab near you this summer.
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Muratahan Aykol retweeted
Frontier science.
Industrial-scale science. Coming to a lab near you this summer.
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Morning: launch an RL run. Afternoon: launch a batch of synthesis attempts. Next morning: check results of both!
Industrial-scale science. Coming to a lab near you this summer.
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Muratahan Aykol retweeted
We aim to make Onnes proud!
Industrial-scale science. Coming to a lab near you this summer.
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Concept to reality in record time. Excited by the progress we’re making.
Industrial-scale science. Coming to a lab near you this summer.
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