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How does our history of influenza infections shape the ability of CD8+ T cells to recognize new viral variants? Our new paper in @CellReports examines these questions using influenza-specific CD8+ T cells! 🧵⬇️ (1/12)
cell.com/cell-reports/fullte…
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Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.
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Join @ATS_GG & @ATS_AII for Journal Club: Extensive Acute & Sustained changes to Neutrophil Proteomes Post-SARS-CoV-2 infection on Jan. 14 at 11 am eastern featuring @MereteLong @ProfJDChalmers @hellofuture100 @donsin4 @KapellosTS @JPantaleonMD
Register: site.thoracic.org/events/ext…
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Our next journal club is on 7 Nov at 4pm ET/1pm PT! "Distinctive Evolution of Alveolar T-cell Responses is Associated with Clinical Outcomes in Unvaccinated Patients with SARS-CoV-2 Pneumonia" presented by Dr. @luisamnMD Morales-Nebreda. Register at thoracic.zoom.us/meeting/reg…
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Single-cell genomics meets human genetics go.nature.com/3LjdSmL by @AnnaSECuomo, @aparnanathan, @soumya_boston, @dgmacarthur and @drjosephpowell
Free to read here: rdcu.be/darro #sceQTL
Proud of my brilliant friends and collaborators for their well deserved honor! Congrats @oanheei and @louiserowntree !!!!!!!!!!!!!!
Congratulations to Dr @oanheei & Dr @louiserowntree from the Doherty Institute for being awarded the @UniMelb 2024 Woodward Medal (Science & Tech) for their groundbreaking work on human T-cell responses to respiratory viruses, including COVID-19. 🌟👏 go.unimelb.edu.au/wm78 @UniMelbMDHS @TheRMH
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TCR repertoire dream: decoding immune status by sequencing TCRs. Problems: 1) Need paired TCRab chains 2) Interesting T cell clones are often VERY small. Our solution: TIRTL-seq 🐢Deep, quantitative, & affordable paired TCR repertoire sequencing. 🧵 biorxiv.org/content/10.1101/… (1/11)
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At a recent conference @AthenaAktipis invited me to give a talk on the role of creativity in science. For those interested here are the illustrated slides in tweetorial format. The take home message: Creativity and science go hand in hand. (Thread 1 of 2)
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So happy to share our incredible work, just published in @CellCellPress. We found that high expression of OLAH drives life-threatening immune responses. OLAH directly impacts disease severity in multiple globally relevant, but distinct viral infections. tinyurl.com/3xupbr2k
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MIS-C is a rare post-COVID syndrome impacting children, though a direct connection between SCoV-2 & severe inflammation is undefined
In our new collaborative effort w/UCSF & Boston Children's, we find a cross-reactive epitope could be the MIS-Cing link. A🧵nature.com/articles/s41586-0…
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Our latest, from the brilliant @wchenomics and @_Choi_Junhong, out in @Nature , is ENGRAM, a multiplex method for symbolic recording of signaling and cis regulatory activity to DNA. Final version (not in preprint) includes integration w/ DNA Typewriter. rdcu.be/dN62L
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously.
nature.com/articles/s41586-0…
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Have you ever wondered why there are so many subtypes of immune cells? In our work published today at @Nature, we offer one possible reason – the capacity to evolve. 1/n nature.com/articles/s41586-0…
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NEW: @UMichSPH prof @AubreeGordonPhD has been awarded a $6.7 million five-year grant to advance her innovative research into influenza immunity development among children. "This study represents a monumental step toward understanding how early influenza exposure—whether through infection or vaccination—shapes the immune systems of children in the long term."
Read: myumi.ch/VGrwe
ALT Aubree Gordon holding a pipette in a lab at the University of Michigan School of Public Health
This was so fun and filled with great discussion with the panelists and audience! I had a great time! Thanks @JPantaleonMD for organizing!
Fantastic work in the Mechanisms of Lung Inflammation and Infection poster discussion session! @TimFlerlage presented incredible single cell data on influenza induced ARDS. Amazing to see a good friend and collaborator Yohannes Mebratu moderating the session! #ats2024
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We've underestimated the role and activation of the immune system in patients with heart attacks. A comprehensive multi-omic analysis uncovers the role of T cells and monocytes
nature.com/articles/s41591-0…
@NatureMedicine @KPekayvaz @LMU_Uniklinikum and colleagues
Tacos with friends on the water and puppy cuddles. Also, amazing science at the Charting lung omics session (not pictured). Great morning at #ats2024 @aanaishe @TimFlerlage
Started #ATS2024 off with some great friends and colleagues! Lucky to be a part of an incredible group in @ATS_GG!!
@RachelSKelly4 @aanaishe @MattMollpulmccm @JPantaleonMD
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Delighted to invite everyone to our members meeting at #ATS2024! Featuring a keynote from Trey Ideker @TreyIdeker "Building a Mind for Human Disease"! Taking place on Sunday May 19th from 11:45am-1:15pm in Coronado (South Tower, Level 4) at the Marriott Marquis San Diego Marina.
ALT Please join us for the Section on Genetics & Genomics (SGG) Membership Meeting. FEATURING A KEYNOTE ADDRESS BY TREY IDEKER, PHD Building a Mind for Human Disease Trey Ideker, PhD, is a 20-year Professor of Medicine, Bioengineering and Computer Science, and former Chief of Genetics, at the University of California San Diego (UCSD). Additionally, he is Director or Co-Director of the Bridge2AI Functional Genomics Data Generation Program, the Cancer Cell Map Initiative, the National Resource for Network Biology, and the UCSD Graduate Program in Bioinformatics and Systems Biology, all NIH-funded efforts. Time: Sunday, May 19 | 11:45 a.m. – 1:15 p.m. Location: Marriott Marquis San Diego Marina Room: Coronado (South Tower, Level 4)