ekaitys (@ekaitys) profile picture

ekaitys

@ekaitys

Human genetics and Immunology • Paul Thomas Lab at St. Jude • Grad school @ UVA with Michele Sale • Undergrad @ beautiful Clemson University

Joined December 2015
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Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)Photo by ekaitys (@ekaitys)
How does our history of influenza infections shape the ability of CD8+ T cells to recognize new viral variants? Our new paper in @CellReports examines these questions using influenza-specific CD8+ T cells! 🧵⬇️ (1/12) cell.com/cell-reports/fullte…
Image from Paul G Thomas (@PGTimmune)
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Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.
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Join @ATS_GG & @ATS_AII for Journal Club: Extensive Acute & Sustained changes to Neutrophil Proteomes Post-SARS-CoV-2 infection on Jan. 14 at 11 am eastern featuring @MereteLong @ProfJDChalmers @hellofuture100 @donsin4 @KapellosTS @JPantaleonMD Register: site.thoracic.org/events/ext…
Extensive Acute and Sustained Changes to… | American Thoracic Society

Extensive Acute and Sustained Changes to… | American Thoracic Society

The American Thoracic Society is the world's leading medical society dedicated to accelerating the advancement of global respiratory health through…

site.thoracic.org
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Our next journal club is on 7 Nov at 4pm ET/1pm PT! "Distinctive Evolution of Alveolar T-cell Responses is Associated with Clinical Outcomes in Unvaccinated Patients with SARS-CoV-2 Pneumonia" presented by Dr. @luisamnMD Morales-Nebreda. Register at thoracic.zoom.us/meeting/reg…
Image from ATS G&G Section (@ATS_GG)
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Single-cell genomics meets human genetics go.nature.com/3LjdSmL by @AnnaSECuomo, @aparnanathan, @soumya_boston, @dgmacarthur and @drjosephpowell Free to read here: rdcu.be/darro #sceQTL
Single-cell genomics meets human genetics

Single-cell genomics meets human genetics

Nature Reviews Genetics - In this Review, the authors describe the emerging field of single-cell genetics, which lies at the intersection of single-cell genomics and human genetics. They review the...

nature.com
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TCR repertoire dream: decoding immune status by sequencing TCRs. Problems: 1) Need paired TCRab chains 2) Interesting T cell clones are often VERY small. Our solution: TIRTL-seq 🐢Deep, quantitative, & affordable paired TCR repertoire sequencing. 🧵 biorxiv.org/content/10.1101/… (1/11)
TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing

TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing

α/β T cells are key players in adaptive immunity. The specificity of T cells is determined by the sequences of the hypervariable T cell receptor (TCR) α and β chains. Although bulk TCR sequencing...

biorxiv.org
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At a recent conference @AthenaAktipis invited me to give a talk on the role of creativity in science. For those interested here are the illustrated slides in tweetorial format. The take home message: Creativity and science go hand in hand. (Thread 1 of 2)
Image from Alex Cagan (@ATJCagan)
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So happy to share our incredible work, just published in @CellCellPress. We found that high expression of OLAH drives life-threatening immune responses. OLAH directly impacts disease severity in multiple globally relevant, but distinct viral infections. tinyurl.com/3xupbr2k
Image from The Jeremy Chase Crawford Lab (@theJCClab)
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MIS-C is a rare post-COVID syndrome impacting children, though a direct connection between SCoV-2 & severe inflammation is undefined In our new collaborative effort w/UCSF & Boston Children's, we find a cross-reactive epitope could be the MIS-Cing link. A🧵nature.com/articles/s41586-0…
Molecular mimicry in multisystem inflammatory syndrome in children

Molecular mimicry in multisystem inflammatory syndrome in children

Nature - A cross-reactive antibody and T cell response is identified in a large portion of patients with multisystem inflammatory syndrome in children.

nature.com
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Our latest, from the brilliant @wchenomics and @_Choi_Junhong, out in @Nature , is ENGRAM, a multiplex method for symbolic recording of signaling and cis regulatory activity to DNA. Final version (not in preprint) includes integration w/ DNA Typewriter. rdcu.be/dN62L
Will Chen (@wchenomics) profile pictureWill Chen@wchenomics17 Jul 2024
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s41586-0…
Symbolic recording of signalling and cis-regulatory element activity to DNA

Symbolic recording of signalling and cis-regulatory element activity to DNA

Nature - Enhancer-driven genomic recording of transcriptional activity in multiplex (ENGRAM) is used for multiplex recording of the cell-type-specific activities of dozens to hundreds of...

nature.com
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Have you ever wondered why there are so many subtypes of immune cells? In our work published today at @Nature, we offer one possible reason – the capacity to evolve. 1/n nature.com/articles/s41586-0…
Interactions between immune cell types facilitate the evolution of immune traits

Interactions between immune cell types facilitate the evolution of immune traits

Nature - By profiling immune cell variation in bone marrow of 54 genetically diverse mouse strains and analysing the evolutionary record, we found that genes associated with the frequency of...

nature.com
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NEW: @UMichSPH prof @AubreeGordonPhD has been awarded a $6.7 million five-year grant to advance her innovative research into influenza immunity development among children. "This study represents a monumental step toward understanding how early influenza exposure—whether through infection or vaccination—shapes the immune systems of children in the long term." Read: myumi.ch/VGrwe
Aubree Gordon holding a pipette in a lab at the University of Michigan School of Public Health

ALT Aubree Gordon holding a pipette in a lab at the University of Michigan School of Public Health

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We've underestimated the role and activation of the immune system in patients with heart attacks. A comprehensive multi-omic analysis uncovers the role of T cells and monocytes nature.com/articles/s41591-0… @NatureMedicine @KPekayvaz @LMU_Uniklinikum and colleagues
Image from Eric Topol (@EricTopol)
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Delighted to invite everyone to our members meeting at #ATS2024! Featuring a keynote from Trey Ideker @TreyIdeker "Building a Mind for Human Disease"! Taking place on Sunday May 19th from 11:45am-1:15pm in Coronado (South Tower, Level 4) at the Marriott Marquis San Diego Marina.
Please join us for the Section on Genetics & Genomics (SGG) Membership Meeting. FEATURING A KEYNOTE ADDRESS BY TREY IDEKER, PHD Building a Mind for Human Disease Trey Ideker, PhD, is a 20-year Professor of Medicine, Bioengineering and Computer Science, and former Chief of Genetics, at the University of California San Diego (UCSD). Additionally, he is Director or Co-Director of the Bridge2AI Functional Genomics Data Generation Program, the Cancer Cell Map Initiative, the National Resource for Network Biology, and the UCSD Graduate Program in Bioinformatics and Systems Biology, all NIH-funded efforts. Time: Sunday, May 19 | 11:45 a.m. – 1:15 p.m. Location: Marriott Marquis San Diego Marina Room: Coronado (South Tower, Level 4)

ALT Please join us for the Section on Genetics & Genomics (SGG) Membership Meeting. FEATURING A KEYNOTE ADDRESS BY TREY IDEKER, PHD Building a Mind for Human Disease Trey Ideker, PhD, is a 20-year Professor of Medicine, Bioengineering and Computer Science, and former Chief of Genetics, at the University of California San Diego (UCSD). Additionally, he is Director or Co-Director of the Bridge2AI Functional Genomics Data Generation Program, the Cancer Cell Map Initiative, the National Resource for Network Biology, and the UCSD Graduate Program in Bioinformatics and Systems Biology, all NIH-funded efforts. Time: Sunday, May 19 | 11:45 a.m. – 1:15 p.m. Location: Marriott Marquis San Diego Marina Room: Coronado (South Tower, Level 4)

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Check out our Early Career Workshop on Collaboration in Omics from @ATS_GG with Drs David Christiani and Mark Wurfel. Thx to co-facilitators @ekaitys @RachelSKelly4 @IainKon and all the people who came and made the event interesting thoracic.org/members/assembl…
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Really enjoying many amazing talks at #AAI2024 and seeing the field move forward together with collaborative synthesis. Makes talks that insist on their own way against overwhelming evidence really stand out.
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Our next webinar "Charting the lung" is on 23 April at 11:30am EST! Register at thoracic.zoom.us/meeting/reg…
Image from ATS G&G Section (@ATS_GG)
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Section of Genetics and Genomics presents: “Charting the lung: annotations and ontologies, towards a consensus lung cell atlas” Tuesday, April 23 from 11:30-1PM EST Register here: thoracic.zoom.us/meeting/reg…
Image from Rachel.S.Kelly (@RachelSKelly4)
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🗣️POSTPONED. See new date & time below! 👇 📅 Monday, November 2⃣0⃣ 🕒3 PM EST 🔗thoracic.zoom.us/meeting/reg…
ATS_Assemblies (@ATS_Assemblies) profile pictureATS_Assemblies@ATS_Assemblies1 Nov 2023
🤓Come join us for @ATS_GG's & @ATS_AII's journal club on, "Baseline Innate and T Cell Populations are..." w/@StJudeResearch's own @RMettelman! 📅Mon, Nov 6⃣ 🕒3 PM EST 🔗thoracic.zoom.us/meeting/reg…
Image from ATS_Assemblies (@ATS_Assemblies)
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🤓Come join us for @ATS_GG's & @ATS_AII's journal club on, "Baseline Innate and T Cell Populations are..." w/@StJudeResearch's own @RMettelman! 📅Mon, Nov 6⃣ 🕒3 PM EST 🔗thoracic.zoom.us/meeting/reg…
Image from ATS_Assemblies (@ATS_Assemblies)
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