Our group studies the molecular and systems biology of blood cell development. We focus on T cells and the way they split from other developmental alternatives.
@Caltech
Joined April 2020
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@EVRlab retweeted
There it is, the thymus DOES matter postnatally! Congratulations @ScaddenLab nejm.org/doi/full/10.1056/NE…
@EVRlab retweeted
Multi-scale reprogramming of chromatin organization underlies immunological memory and dysfunction in human CD4+ T cells @SciImmunology @R_Stadhouders @G_Stik
science.org/doi/10.1126/scii…
@EVRlab retweeted
Excited to introduce scKINETICS, an algorithm for joint inference of gene regulatory mechanism and cellular velocity, co-developed by the amazing duo of @CassBurdziak and @juuuulianaar
academic.oup.com/bioinformat…
@EVRlab retweeted
Are you a developmental or cell biologist?
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Yes? Try @Co_Biologists Mastodon server @biologists.social
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@EVRlab retweeted
Our latest: Cis-regulatory strategies for morphogen dependent cell fate decisions
Two ways CREs interpret morphogens
1. Differential binding: CREs bind cell type TFs
2. Differential access: availability of CREs is cell type specific
sciencedirect.com/science/ar…
@EVRlab retweeted
💥💥Excited that our TETact study has now been published in @NatureComms nature.com/articles/s41467-0… @ChanWingFuk did a huge amount of new work in response to reviewers comments (e.g. multiple cell types, multiple genes activated in the same cell)
Happy to share new work from our lab @WEHI_research. Frustrated by the inability to activate heavily methylated genes @ChanWingFuk fashioned a dCas9-TET1 based activation module he named TETact. Check it out 👇👇biorxiv.org/content/10.1101/…
@EVRlab retweeted
For centuries we've had anatomical maps of how the body's organs are connected, but what would a diagram of the immune system’s connections look like? In @Nature we report our initiative to map the "interactome" that links human immune cells together (1/14)nature.com/articles/s41586-0…
@EVRlab retweeted
The most important thing is to figure out the experiment that would kill the project (if X is not true, then the whole thing fails). As Shalin states "beg, borrow and steal (from other funded projects)" to get THIS key experiment done.
@EVRlab retweeted
Abstract Submissions Extended to 6/27! #TravelAwards Avail!
Talk #LymphocyteDifferentiation #GeneRearrangement #GenomeArchitecture & more at The #MolecularMechanism of #ImmuneCellDevelopment and Function Conf., 7/31-8/4 #MMSRC22
Info bit.ly/3KxJGAT
Students: $150 off
ALT Launched in 2003, this FASEB Research Conference is distinctive for its focus on the fundamental mechanisms that control gene expression, differentiation, genome architecture, and function in diverse cell types in the immune system. The conference's main themes are: 1) Explore how molecular interactions, epigenetics, and chromatin architecture control gene expression, recombination, and cellular development and function; 2) Understand the transcriptional regulatory circuits that control immune cell differentiation and function; 3) Discuss molecular and systems-level approaches to understanding how gene regulation and cellular identity in immune cells is linked with disease—with a new session devoted to immuno-oncology.
Kris will be giving a talk on July 31 at the Molecular Mechanisms of Immune Cell Development & Function FASEB conference in Nova Scotia (July 31-August 4). You can register here: bit.ly/3MFDMzn
@EVRlab retweeted
Hot from the oven! Take a look at the newest publication from the lab! In this essay, we discuss about the interplay between genome architecture and totipotency. Great work from @TeresaOlbrich !
doi.org/10.1002/bies.2022000…
@EVRlab retweeted
One of the best compliments I ever got on my bioinformatics work was (indirectly) from Ellen Rothenberg, and what made it good was the staggering depth of knowledge backing it up. No surprise here but big congrats.
I am delighted and extremely grateful to join such a terrific group of scientists in @theNASciences . Thanks to my great lab members, and thanks to the colleagues and reviewers who have been a constant inspiration and who have appreciated, criticized, and improved our work.
@EVRlab retweeted
Very happy to share that our paper on the oncogenic and tumor suppressor functions of LEF1 in T cell leukemia is now published! @UChicagoCCB @UChicagoImmuno @UCCancerCenter frontiersin.org/articles/10.…
@EVRlab retweeted
Our latest story of chromatin folding driving drug resistance is out!
sciencedirect.com/science/ar…
@EVRlab retweeted
We are excited to introduce CaRPool-seq, a new technology that utilizes Cas13 to perform combinatorial single-cell perturbation screens! Check it out, esp. if you're interested in simultaneously perturbing multiple genes and exploring genetic interactions: biorxiv.org/content/10.1101/…
@EVRlab retweeted
NEW at the 13th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia. myeloidmeeting.org
Send in your HOT unpublished abstract for a poster, get selected for a short talk, and we pay your hotel bill!
@EVRlab retweeted
This seems extremely problematic. I am almost speechless, but the fatalist in me wonders if this kind of future is inevitable.
Learning on knowledge graph dynamics provides an early warning of impactful research go.nature.com/3eTxOwr
@EVRlab retweeted
Very excited to share our latest review, discussing the functional importance and spatiotemporal dynamics of the #3DGenome in development @Dev_Cell. Led by the fantastic @erin_aboelnour cell.com/developmental-cell/…
@EVRlab retweeted
Both my Ph.D. and postdoc mentors were men but I have had a few very influential female mentors. Ana Cumano @ana09837244 taught me everything in the lab, and Ellen Rothenberg @evrlab has been a constant champion. Thanks to both of you on #InternationalDayOfWomenInScience
@EVRlab retweeted
“You spend so much of your life energy just trying to hold it together. And this is a big deal. For us just to be able to get some peace.”
Van Jones reacts after CNN projected Joe Biden as the winner of the presidential election. cnn.it/2Id1pmU