Combining DNA nanotech with whole body tissue clearing PhD candidate @ertuklab
Munich
Joined November 2021
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Excited to share the main project of my PhD✨ We used DNA hybridization to attach targeting ligands to lipid nanoparticles (LNPs), enabling cell-specific delivery in vivo. #DrugDelivery #LNP #Nanomedicine
We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic.
It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. by @cerenkimna @kalorintschi biorxiv.org/content/10.1101/…
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Karoline retweeted
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. nature.com/articles/s41587-0…
Karoline retweeted
Hot off the press @CellCellPress! 📰 Excited to share a significant portion of my PhD work and my first major publication. The skull's role in the neuroimmune axis has been a hot topic, and our study showcases its potential for future neuroimmune research & even clinics
Exciting🥳 Our new study in Cell shows that our skull is a gateway for diagnosing & potentially treating brain diseases such as Alzheimer's & stroke. Imagine a future where a portable sensor on the skull can monitor brain health! @CellCellPress cell.com/cell/fulltext/S0092… 🧵👇🏼with🔈
Amazing work, showing the biodistribution of DNA origami nanoparticles on a whole body level-at cellular resolution! Congrats @MolbayM 😊
We are thrilled to present our new study unlocking precision in nanoparticles. Cell-level resolution imaging is key in targeted nanoparticle development. See our work on DNA Origami🧬: biorxiv.org/content/10.1101/…
by @MolbayM, @shan_heather, Benni Kick et al, with @hendrik_dietz.🧵👇🏼
Very useful tool for automated image analysis in the brain! Watch the tweetorial below to find out how it works😊 congrats to @Dorie00 @Rami96614090 and @moritz_negwer
Want to use deep learning for image analysis but lack the coding skills? We introduce DELiVR, a game-changer in brain-wide cell analysis. No coding required, our Fiji Plug-in does the magic. Hats off to @Dorie00, @Rami96614090, @moritz_negwer! 🧵👇🏼 1/n biorxiv.org/content/10.1101/…
Karoline retweeted
😮~60% of us who had COVID still might have lingering viral spikes in our heads! Our new study reveals SARS-CoV-2 spike accumulation in the skull-meninges-brain axis & its implications in long COVID. By @zhouyi_rong @HongchengM @Sakethkapoor🔬🧠🦠🧵👇 biorxiv.org/content/10.1101/…
Karoline retweeted
😮👀DISCO clearing is getting wild, @erturklab. 🤩3D label,&clear&image whole mouse bodies with your💖antibodies. Have a pick at our @syGlassVR showcases (discotechnologies.org/wildDI…).
Try our new recipe @HongchengM & @jieluo692 👇 biorxiv.org/content/10.1101/…
Amazing work from my collegues @jieluo692 and @HongchengM☺️ they developed a whole-body antibody labeling technique (wildDISCO) that is compatible with tissue clearing!
Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By @HongchengM @jieluo692 biorxiv.org/content/10.1101/… 🧵👇🏼(turn on the sound)
Amazing work on robotics aided spatial proteomics by my collegues now out (and on the cover of) @CellCellPress . Congrats guys🥳
Spatial-omics goes 3D🤗! Out at Cell @CellCellPress 👉🏼 We developed DISCO-MS with @labs_mann, a spatial proteomics technology for specimens fully imaged in 3D. DISCO-MS is aided by robotics and enables the study of diseases at their early stages. cell.com/cell/fulltext/S0092…🧵👇
New work from our lab showing that the skull is more than just a physical barrier!
The skull is considered a physical barrier (helmet) for the brain. Our new findings show that the skull can be utilized to interact and monitor neuroinflammation in diverse brain diseases.
#scRNAseq #proteomics #skull #AI #clearing #TSPOPET
biorxiv.org/content/10.1101/… details🧵👇1/n
Karoline retweeted
💡 Just published & selected as an @ACSPublications Editors' Choice: Antigen-Triggered Logic-Gating of DNA Nanodevices by Engelen, Sigl, @kalorintschi, Willner, @hendrik_dietz
🔓 OPEN ACCESS fal.cn/3kQwb
Karoline retweeted
Tissue clearing yields cool 3D images but not much molecular data. Not anymore🤗
Meet DISCO-MS enabling unbiased proteomics profiling of 3D-imaged organs. biorxiv.org/content/10.1101/…
We co-developed with @labs_mann work by @HarsharanBhatia & @ADBxMPIB collab. with @fabian_theis🧵👇