@lstops

👩🏽‍🔬Proteomics, MHCs. PhD @MITdeptofBE, @UWMadison_BME alum | Currently starting a startup- follow along on IG @laurenstopfer 📷

 New York, NY
laurenstopfer.com
Joined June 2011
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I’m delighted to share our @NatureCancer paper by Anne Kraemer et al. nature.com/articles/s43018-0… Our objective was to investigate whether there are substantial differences in the antigenic landscape presented in tumors that are T cell inflamed versus those that are non-inflamed.
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Letter from >400 biopharma execs "If courts can overturn drug approvals without regard for science or evidence, or for the complexity required to fully vet the safety and efficacy of new drugs, any medicine is at risk for the same outcome as mifepristone" docsend.com/view/2ahvmwy8djz…
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Pillar VC
@pillar_vc4 Apr 2023
At @pillar_vc, we’re open-sourcing all the knowledge and knowhow of building biotech companies. Today, we’re releasing the @pavecomp + Founder-Led Bio Community compensation study. 🧬90 companies 🧫3.7k salary data points ✅industry-wide benchmarking founderledbio.com/biotech-co…
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Devin Quinlan@devinquinlan9 Mar 2023
👉We are recruiting for our Summer Fellowship!🚀 The MPM Summer Fellowship is a full-time experience with our investment team to explore the frontiers of science & medicine and help create the next generation of therapeutics companies! Apply at: [email protected]
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MSAID
@msaid_de8 Mar 2023
Happy #InternationalWomensDay🌷 We celebrate the incredible achievements and outstanding contributions of women in proteomics and the mass spec industry. Your dedication shapes the future of science! #IWD2023
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Josh Peters
@joshpetepeters23 Jan 2023
pMHC coated nanovials enable linking TCR sequence to target biorxiv.org/content/10.1101/…

Defining T cell receptor repertoires using nanovial-based affinity and functional screening

The ability to selectively bind to antigenic peptides and secrete cytokines can define populations of cells with therapeutic potential in emerging T cell receptor (TCR) immunotherapies. We leverage...

biorxiv.org
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Elizabeth McKenna@ElizSMcKenna9 Jan 2023
The January issue of @CD_AACR is now online and I couldn't be more excited about how we are kicking off the year! Check it out: aacrjournals.org/cancerdisco…
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Countdown to 2023: #JITCTop10 - Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins bit.ly/3avo8ZR @timisstuck @ThereseMarieC @stefanispranger
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Jim Wells@realJimWells2 Dec 2022
Great collaboration from ⁦@NickRettko⁩ and ⁦@lstops⁩ from Forest White's lab where we show MEKi can increase presentation of pMHC's derived from tumor-associated antigens, which can be targeted with BiTEs for enhanced cytotoxicity in melanoma! pnas.org/doi/10.1073/pnas.22…

MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas | PNAS

Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma—namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors (ICIs), and ...

pnas.org
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Last days to register to the Annual Proteomics Symposium! Opening talk by Lauren Stopfer (@lstops) and many other talks by lead researchers in #proteomics⬇️⬇️⬇️ 🗓️ Nov 11 📌 Auditorium @the_prbb ✍️🏿 FREE Registration bit.ly/ProtSymp22 #ICTSNews @epic_xs @SEProt_Oficial
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Apoorva
@apoorvasriniva18 Oct 2022
get you someone who loves you the way biotech startups love george church on their board
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ACIR
@ACIR_org1 Aug 2022
SPOTLIGHT: Dendritic cell-mediated cross presentation of tumor-derived peptides is biased [...] @kochinstitute @timisstuck @MITBiology @lstops @stefanispranger @ragoninstitute. Originally published in @jitcancer. To read our summary click ow.ly/8soy50K67im and scroll down.
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The Spranger and White Labs developed a new method for surveying cross-presentation of antigens by dendritic cells. The new tool could help researchers understand why some patients and tumor types don't respond to immune checkpoint therapy. ki.mit.edu/news/2022/cross-p…
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Science in Boston
@ScienceinBoston15 Jul 2022
Drs. @StefaniSpranger and Forest White and a team at the @KochInstitute developed a method that could help researchers understand why some patients and tumor types do not respond to #ImmuneCheckpoint therapies. 🚧 @lstops @timisstuck 🖱️ Learn more: bit.ly/3PpB0PS
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timisstuck@timisstuck13 Jul 2022
We also got @lstops to measure, for the first time everrrr, the number of peptides cross-presented per cell using quantitative mass spec! This validated our basic finding that membrane-associated proteins are poorly cross-presented. Such a cool technique, I'm still in awe.
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ACIR
@ACIR_org29 Jun 2022
A new genetically-engineered mouse model (GEMM) enables purification of pMHCs from cells of interest, allowing for specific evaluation of the immunopeptidome of #cancer cells in vivo @kochinstitute @ajaeger40 Read our summary here => ow.ly/OmUk50JKvjz
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Peter Westcott@PeterMKWestcott16 Jun 2022
Here's an approach that will find many applications for years to come—a new mouse model enabling deep cell-specific profiling of the immunopeptidome in vivo. Amazing to see @ajaeger40's vision come to life and a privilege to be an extra in this tale. Congrats to all involved!
Alex Jaeger@ajaeger4015 Jun 2022
Proud to share my work out today in @Nature interrogating antigen presentation in vivo! We found that physiological context shapes the antigenic repertoire of cancer cells and describe a new tool to uncover tissue and cell type specific antigens in vivo. nature.com/articles/s41586-0…
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Alex Jaeger@ajaeger4015 Jun 2022
Thank you to my colleagues @LabJacks @lstops @RyuhjinAhn @DemiSandel @PeterMKWestcott @timisstuck @santinoids @peterswinter @JMSchenkel @stefanispranger @shaleklab And everyone else who helped bring this story to life!
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Mass Spec Mommy@MassSpecMommy7 Jun 2022
Overheard at #asms2022: we are all at the mercy of a vacuum pump.
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Timothy Kassis
@TimothyKassis3 Jun 2022
Hey #TeamMassSpec what are some must-see talks at #ASMS2022? I need recommendations. Brand new to ASMS. Putting my schedule together. #massspec #metabolomics
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