Genomics technologist, Psychiatrist, Associate Professor, Massachusetts General Hospital @broadinstitute. Founder, Curio Bioscience
Joined May 2012
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Evan Macosko retweeted
“Cellular scaling laws in the mammalian brain” by Fei Chen & Evan Macosko is out in Cell! It dovetails with many of the neuro ideas I’m always pushing, but in the context of transcriptomics and psych. Thanks Fei & Evan for lots of great conversations while they were working on this! @insitubiology cell.com/cell/fulltext/S0092…
Evan Macosko retweeted
1/8 We learned what kinds of neurons are in the brain with Drop-seq, and where they are located with Slide-seq/tags. But what about their synaptic anatomy?
Protein-guided RNA barcoding links transcriptomes to synaptic architecture biorxiv.org/content/10.64898… #biorxiv_neursci
Evan Macosko retweeted
We developed an imaging-free spatial genomics technology where DNA barcodes diffuse to connect locally. Using UMAP, we reconstructed the physical locations of these barcodes, transforming spatial transcriptomics into purely molecular biology.
biorxiv.org/content/10.1101/…
Evan Macosko retweeted
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
Evan Macosko retweeted
Hear us talk about Slide-tags!
Slide-tags: Combining single-nucleus genomics with spatial measurements 🧬🔬
Hear from @AndyRusss, @jacksonweir4, Naeem Nadaf, and @insitubiology as they describe the development and application of this impressive technology
youtu.be/4TJkLI4LINU
Evan Macosko retweeted
I am thrilled to announce that I will be joining the Department of Genetics at Trinity College Dublin (@tcdgenmicro) in summer 2024! My lab will build and apply new tools to understand the formation and function of microglia states in brain health and disease.
Evan Macosko retweeted
Findings "strongly imply that there is no specific link between maternal mental illness or maternal infection during pregnancy" & neurodevelopmental disabilities (including autism) in offspring cambridge.org/core/journals/… free
Evan Macosko retweeted
Delighted to announce our work developing an approach to understand the function of human microglial states. @MartineTherrie4 and I will guide you through our work, a collaboration with @sasajereb from @macosko and @stevens1lab ! nature.com/articles/s41590-0…
Evan Macosko retweeted
Single-cell or spatial?
Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics
➡️ doi.org/10.1101/2023.04.01.5…
Evan Macosko retweeted
Introducing Slide-tags: our new technology for truly single-cell, multi-modal spatial genomics!
Had a blast working alongside @AndyRusss, @Naeemnadaff, @macosko, @insitubiology, and the rest of our team on this project!
biorxiv.org/content/10.1101/…
1/9
Evan Macosko retweeted
Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 7. Talks will feature recent exciting computational and experimental advances and will be livestreamed at satijalab.org/scgd. Please RT/spread the word!
Evan Macosko retweeted
Excited to present our work developing tools to model & manipulate human brain microglia subtypes in a dish. Hope this will open up microglia and their disease-associated states to functional genomics!
biorxiv.org/content/10.1101/…
Evan Macosko retweeted
My lab is hiring! We're located at the Crick Institute in Central London -- if you want to invent new biotechnologies to measure and control biological systems, get in touch!
Evan Macosko retweeted
The perennial question of neurodegeneration is "why some neurons, not others?"
Our work (@macosko, @abdul_squared, et al, myself), in @NatureNeuro, has led us to believe that the answer, for Parkinson's disease, lies in the genetics: nature.com/articles/s41593-0…
And,two things: (1/4)
Evan Macosko retweeted
How do genetic and environment interact to alter microglia states and functions in health & disease?
Excited to share preprint collaboration with @macosko led by @MartineTherrie4 @dolanmjg @sasajereb and many others
biorxiv.org/content/10.1101/…
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Evan Macosko retweeted
Excited to share our paper published in @NatureNeuro. With #scRNAseq, machine learning, and #Slideseq, we were able to reconstruct the mouse olfactory glomerular map and explore the potential mechanism of how this map is formed.
@UMassChan
@ProgMolMed
nature.com/articles/s41593-0…
Evan Macosko retweeted
@stevens1lab and @macosko looking for Project Manager I, neurodegeneration data science initiative passionate about data sharing and integrative analyses Please share and RT 1/2 broadinstitute.wd1.myworkday…
Evan Macosko retweeted
As we conclude Next-Generation Genomics 2021, thanks to @cziscience, our OC, our viewers, and an incredible set of speakers! All of them opened or spent their lab's early years in a global pandemic, and their resilience and output is inspirational. See you next year!
Evan Macosko retweeted
We are excited to open (free!) registration for Next Generation Genomics 2021! Amazing line-up of junior speakers developing new methods in single-cell/spatial analysis, genome engineering, comp. bio, and population genetics. Register+submit an abstract at nextgengenomics.org
Evan Macosko retweeted
We are recruiting for two computational biologist positions! Applicants at all career stages welcome. Please apply if you'd like to train and work on exciting problems in single-cell genomics, spatial analysis, and statistical learning. Just send your CV by e-mail/DM. Please RT!