@tkam80

@mghmedres intern | prev @harvardMITmdphd @broadinstitute @macosko lab

 Cambridge
Joined July 2012
  • Tweets98
  • Following297
  • Followers221
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Tushar Kamath retweeted
AbdulAbdul@Abdul_SquaredMay 12
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…

Optics-free spatial genomics for mapping mammalian brain aging by IRISeq

Nature Neuroscience - The authors developed an optics-free spatial genomics method to map mouse brain aging, revealing region-specific inflammation and showing that lymphocytes promote harmful...

nature.com
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Tushar Kamath retweeted
Amanda Urke@amanda_urkeMar 2
2/8 Introducing Synapse-seq: our AAV-based tool for mapping brainwide presynaptic projections or postsynaptic distributions of molecularly-defined neurons, via protein-guided RNA barcoding & single-cell/spatial readouts: doi.org/10.64898/2026.02.26.…
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We are thrilled to have the following superstars join our fellowship program in July 2026.  Congratulations to Erik, Wes, Tushar, Brian, May and Shawna, and congratulations to the MGH GI Division for recruiting such talent.  Welcome to the family!
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Tushar Kamath retweeted
Tarun Kamath@TVKamath12 Nov 2024
The first piece of work from my PhD has now been uploaded to biorXiv! Short 🧵below:
bioRxiv Neuroscience@biorxiv_neursci12 Nov 2024
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Tushar Kamath retweeted
Luke O'Connor@Luke0connor7 Nov 2024
Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by @XihongLin #ASHG24 poster 4089F medrxiv.org/content/10.1101/…

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML

Heritability enrichment analysis using data from Genome-Wide Association Studies (GWAS) is often used to understand the functional basis of genetic architecture. Stratified LD score regression...

medrxiv.org
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Tushar Kamath retweeted
Ajay Nadig@NadigAjay8 Jul 2024
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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Tushar Kamath retweeted
Evan Macosko@macosko13 Dec 2023
We now know the locations of cell types in a full mammalian brain. Our work reveals the brainstem’s absolutely stunning cellular complexity. How and why does it arise? Visit braincelldata.org to plot genes, localize types, and get markers. nature.com/articles/s41586-0…
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Tushar Kamath retweeted
Evan Macosko@macosko13 Dec 2023
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods: 1) Cell segmentation (the biggest problem) 2) robustness and scalability (well-powered case-control studies now possible) 3) Multiomics (ATAC, RNA, etc)
Broad Institute@broadinstitute13 Dec 2023
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
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Excited to share the next chapter of primate genomics in @Nature, where we (@illumina, @IBE_Barcelona, and @bcmhouston) created a multiple sequence alignment of 239 primate species to better understand non-coding regulatory elements! nature.com/articles/s41586-0…
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Excited to announce I will be starting my lab in @BIDMCpath @BIDMC_CancerCtr at @BIDMC . Using chemical genomic approaches and thorough biochemistry we will focus on revealing new mechanisms of metabolism regulated cell death with a special focus on metal (copper) biology.
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Tushar Kamath retweeted
ChrisAWalsh@ChrisAWalsh111 Aug 2023
Wow finally out in print! Great work from @emauryg and great collaborations with @freeseek82 @tkam80 and @macosko
Cell Genomics@CellGenomics10 Aug 2023
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions dlvr.it/StSZRB
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Very excited to see our work on using gene features to identify target GWAS genes out at @NatureGenet
Nature Genetics@NatureGenet13 Jul 2023
✨ ONLINE @NatureGenet 📰 Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases 🧑🏼‍🤝‍🧑🏻 Elle M. Weeks, Hilary K. Finucane and team 👇🏼 go.nature.com/3rnYnT7
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ASO activity at single cell resolution - now published as a @NAR_Open Breakthrough article: academic.oup.com/nar/advance… Blog post on implications for prion prevention: cureffi.org/2023/05/16/asos-… Tweetstorm: xitter.cf/cureffi/status/1625800… Thank you @OnoPharmaFound for funding this 🙏
Eric Vallabh Minikel
@cureffi15 Feb 2023
If an ASO lowers target RNA 50% in bulk brain tissue, is it 50% in all cells or 100% in half? Are cell types all impacted equally? Does CSF reflect neuronal target engagement? We did single-cell seq in ASO-treated mice & NHPs to find out doi.org/10.1101/2023.02.14.5… Thread 👇
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Tushar Kamath retweeted
Evan Macosko@macosko8 Mar 2023
Excited to release our cell type atlas of the adult mouse brain! Here’s our portal: braincelldata.org And preprint: biorxiv.org/content/10.1101/… We find minimal marker sets for all cell types, explore activity-regulated genes, and perform analyses of heritability enrichment.
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Tushar Kamath retweeted
Sophia Liu@immunoliugy11 Oct 2022
Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ! This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and @insitubiology led to some cool findings... cell.com/immunity/fulltext/S… 1/8
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Tushar Kamath retweeted
Tom Morello
@tmorello5 Oct 2022
Congrats to my former ⁦@Harvard⁩ bandmate ⁦@CarolynBertozzi⁩ on her ⁦@NobelPrize⁩ in chemistry! We won the Ivy League Battle of the Bands in 1986 with our rockin’ group ‘Bored Of Education’, with her on keyboards & me in spandex. news.stanford.edu/2022/10/05…
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I learned in medical school that clinical trials are the best test of a hypothesis. In this week’s issue of @NEJM, two anti-synuclein trials tested the hypothesis that α-synuclein is toxic and both were negative. What keeps us from falsifying the hypothesis? (1/8)
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I’ve started a Substack, called Biomarker. This week features interviews with @SchreiberStuart and Bob Langer on a life in science. I also chat with @aloktayi, CEO of @vibe_bio. Lastly, an article on cryptic splicing in #ALS dneel.substack.com – at Boston, MA
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Tushar Kamath retweeted
Ajay Nadig@NadigAjay8 Jul 2022
How does a genetic variant you observe only once or twice in 400k people affect a trait? Im excited to share my first PhD manuscript, co-led with @danweiner92 and supervised by @Luke0connor, that develops a novel statistical approach to the problem of rare variant heritability
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Tushar Kamath retweeted
Mike Dolan@dolanmjg7 May 2022
Excited to present our work developing tools to model & manipulate human brain microglia subtypes in a dish. Hope this will open up microglia and their disease-associated states to functional genomics! biorxiv.org/content/10.1101/…

A resource for generating and manipulating human microglial states in vitro

Microglia have emerged as key players in the pathogenesis of neurodegenerative conditions such as Alzheimer’s disease (AD). In response to CNS stimuli, these cells adopt distinct transcriptional and...

biorxiv.org
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