Author of Rethinking Diabetes, The Case for Keto, The Case Against Sugar, Why We Get Fat, Good Calories, Bad Calories, Bad Science, and Nobel Dreams

Oakland, California
Joined June 2009
The Endocrine Society has a new "scientific statement" on the gaps (or rather black holes) in obesity science. @garytaubes shines cosmic light on the matter. If you don't subscribe to his Substack, this essay alone is worth the price.
Here’s a question from my latest Substack post. It's about obesity and obesity medicine and it should be rhetorical. Regrettably, it's not: Q. If you were going to study a disorder of excess fat accumulation (i.e., too much fat in fat cells) and the action of the drugs that so spectacularly treat it, wouldn’t you be at least vaguely interested in the physiological mechanisms that determine how much fat those fat cells will store? 1. Yes? 2. No? Common sense (and the history of obesity science) might suggest the answer has to be yes, but the expert authors of a recent Endocrine Society Scientific Statement on  “Obesity science, research gaps, and opportunities in the new era of obesity medicines,” would claim otherwise. They put the brain at the center of obesity science and GLP-1 action, then omit (ignore?) a century of science suggesting that since it's the fat cells that get fatter in obesity, the direct neuroendocrine regulation of fat storage in those cells must be relevant. These expert authors include @kevinhallPhD and @danielJdrucker and a half dozen others, and we can assume they know more about obesity than anyone. They’re the experts. But if so, why do they ignore the fat cell itself when discussing why we accumulate excess fat in fat cells, and why GLP-1 drugs do such a remarkable job of reversing that process? What are they missing with their conviction that obesity is an "appetitive behavior" disorder? The Black Hole at the Galactic Core of Obesity and GLP-1 Drug Science uncertaintyprinciples.substa…
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Excited to see the evidence base for ketogenic therapies as a treatment for severe mental illnesses and neurocognitive disorders continue to advance! This systematic review and meta-analysis includes 73 studies. More are on the way! nature.com/articles/s41398-0…
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We recently hosted a Capitol Hill briefing on how nutrition can address chronic disease, improve health outcomes, and reduce healthcare costs in the era of GLP-1s. Watch highlights featuring @RepDavids, Dr. Maya Maroto, @bschermd, @DoctorTro, and Dr. Caroline Roberts.
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Mental health and metabolic health are deeply interconnected, and the science is advancing rapidly. Join us virtually for this Harvard Medical School-accredited CME/CE course September 16–19, 2026. We'll explore the latest research and practical clinical applications related to mental health, metabolism, nutrition, lifestyle interventions, and integrated care models. Only 9 days left to take advantage of the early registration discount. I hope you'll join us! learn.hms.harvard.edu/progra…
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gary taubes retweeted
Proud to share a study lead by PI Judy Ford which I was a co-investigator at @UCSF on: the first randomized controlled trial of ketogenic therapy in schizophrenia-spectrum and bipolar disorders, out now in Schizophrenia Bulletin. Key results: keto was feasible, metabolic markers improved significantly at 1 month, and the 4-month extension showed significant psychiatric symptom reduction and better cognition. 58 participants at UCSF. 1-month RCT + optional 4-month keto extension. Early evidence — but a real step toward metabolic treatments for serious mental illness. Paper: doi.org/10.1093/schbul/sbag0…
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Results of the first-ever randomized controlled trial testing ketogenic therapy in people living with schizophrenia and bipolar disorder were just published in Schizophrenia Bulletin. Here's what was found 🧵
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They expected to learn more about digestion. What they found changed the history of diabetes. In 1889, Oskar Minkowski and Joseph von Mering at the University of Strasbourg surgically removed a dog’s pancreas. They were studying the pancreas’ digestive enzymes and their role in fat digestion. What happened next surprised them. The dog developed polyuria, and its urine contained glucose. The experiment provided the first compelling evidence that the pancreas played a critical role in preventing diabetes, decades before insulin was discovered. You can read more about it in @garytaubes’ excellent book Rethinking Diabetes.
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The Futility of Calorie Counting: “You could put sawdust into a bomb calorimeter and you would get basically 4 calories per gram.... If you’re a termite, yes, you’ll get calories from it. But humans won’t.” apnews.com/article/calories-…
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gary taubes retweeted
Erling Haaland is doing more to effectively dismantle the 1977 US Food Pyramid than @RobertKennedyJc and the entire global low-carb movement combined. (Well almost). @bigfatsurprise @zoeharcombe @TheNoakesF @garytaubes @BenBikmanPhD @AKoutnik @sweatscience
🇳🇴 A velocidade do Haaland.
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gary taubes retweeted
What I'm watching - a lecture by @garytaubes on the causes of obesity ... videocast.nih.gov/watch/94fb…
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NEW PAPER @AJCNutrition Have CONTINUOUS GLUCOSE MONITORS been wrongfully discredited? CGMs (used in diabetes) are now being applied to "Precision Nutrition" Even without diabetes, high-carb foods can spike glucose—tending to make low-carb diets look good Critics cry foul! 1/6
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Arguably the most consequential debate in nutrition today— Ultra-Processed Food 👉Like the low-fat diet debacle of the late 20th century, are we building another house of cards? The inimitable @garytaubes @TheAtlantic Worth finding your way thru paywall theatlantic.com/health/2026/…
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gary taubes retweeted
“Ultra-processed” in the world of nutrition circa 2026 is just the latest synonym for “unhealthy,” @garytaubes writes—but this vague new term may be leading people in the wrong direction. theatlantic.com/health/2026/…
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gary taubes retweeted
One of the regrettable facts about obesity research and its implications for nutrition and public health is that the authorities do not know the history of their own science. I'll try to rectify this at the NIH on Friday, explaining why the energy balance model of obesity--that overeating is the cause--was rejected prior to World War 2 as a "dead end" that explained nothing about why we get fat.
🧐Be sure to join me June 12 at 1:30pm ET for the next talk in the NIH Scientific Freedom Lecture Series, titled “Energy Balance or Fuel Partitioning? A History Lesson in the Science of Obesity Pathogenesis, and Its Implications.” I’ll be joined by Gary Taubes, a science journalist and historian, to discuss how nutrition, fitness, and other factors like genetics influence obesity risk. NIH staff can attend in person in the Masur Auditorium of NIH’s Building 10. The public is invited to attend virtually via webcast. ➡️ bit.ly/3S6bUfr
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Echo Chamber of the Like-Minded? 18 new papers on ultra-processed foods in @AMJPublicHealth As with prior series (eg @lancet), there is remarkably little diversity of opinion. Perhaps inadvertently, the first paper on the TOC (Campos et al) reveals a crucial problem. 1/2
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gary taubes retweeted
What the post also shows is that no single dietary intervention has been shown, in a long term study, to improve long term human health. Not diets that substitute polyunsaturated fats for saturated fats; not diets that replace fat with carbohydrate. Yet I doubt there is a single faculty teaching human nutrition anywhere in the world that ever makes this point. Probably the most important study is the LookAhead study which tested dietary fat reduction in obese type 2 diabetes. After 9.5 years it was given up as a. hopeless failure. Which of course it was not. It was only a failure for those who, filled with cognitive dissonance, have and will continue to prescribe that diet in the hope that somehow their patients will respond differently. Yet what diet does one think is prescribed by "evidence-based" doctors and dietitians, for most of the world's persons living with that condition? On the other hand, the one diet that has yet to be properly investigated with long term trials is the low-carbohydrate high-fat diet. Yet the reason most usually advanced by the "evidence-based" practitioners to explain why the low-carbohydrate diet should not be prescribed is "because there are no long term studies". So instead the diets that are prescribed (because there are long-term trials - regardless of outcomes) are exactly those which long-term studies show are either harmful or without effect. A strange situation is it not? @garytaubes @bigfatsurprise @lowcarbGP @BenBikmanPhD @markkaplan20 @AKoutnik @LoreofRunning1
Another great post from @ProfTimNoakes. Reading it made me wonder whether we may eventually look back at GLP-1s with a similar kind of historical perspective. Not because GLP-1s they “don’t work.” They clearly do many things powerfully. But insulin also worked. Miraculously. Life-savingly. And then, decades later, the story became more complicated. I don’t pretend to know where the GLP-1 story goes from here. But I do wonder whether we’re asking enough long-term questions about appetite suppression, lean mass, nutrition quality, dependency, behavior change, metabolic health, and what “success” actually means beyond weight loss. History doesn’t always repeat but it often rhymes…
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gary taubes retweeted
Thank goodness Gary Taubes @garytaubes chose physics over medicine and then came from there to science journalism. His latest book amazon.com/Rethinking-Diabet… is another masterpiece. His ability to research the history of the medical topics that interest him and to present the material with novelty, accuracy and clarity in a most engaging way, is of the highest quality. I learned two crucial facts from his deep dive into the historical evolution of the management of diabetes of both types. First, when insulin was discovered in 1921, it produced an instant miracle cure by saving the lives of those who were unable to produce any insulin, those with type 1 diabetes. But the honeymoon period lasted just 15-20 years after which insulin-treated diabetics began to present with premature atherosclerosis. By which time, the prevailing opinion had become that this was caused by a diet too high in fat. For the life-saving insulin had to be innocent - Remember Semmelweis and the doctor-caused disease that he decribed. Thus the prescribed treatment for diabetics of both types became a low-fat high-carbohydrate diet, just as was being prescribed to cardiac patients to prevent disease progression. Second, Taubes made the telling point, overlooked by many, that one of two diets is prescribed to prevent atherosclerosis in normal persons and in those with diabetes. There are the fat substitution diet and the low-fat diet - and they act quite different especially in persons with insulin-resistance or type 2 diabetes. In the fat substitution diet, saturated fats are replaced with polyunsaturated fats. There have been numerous long-term multi-million $ trials of this dietary intervention. They have all failed miserably to show benefit and some have caused harm openheart.bmj.com/content/8/…. Thus we know that the fat substitution diet is a complete failure and may even be harmful. In the low-fat diet, a large portion of the fat in the diet is replaced with carbohydrate. Whilst this diet may be acceptable for those who are not insulin-resistant, for those who are diabetic, it has to be the worst possible choice. Because, with time as the patient becomes progressively more insulin resistant, he/she will require ever larger doses of insulin to maintain blood glucose concentrations in a reasonable range. And didn't the problem of atherosclerosis first appear in middle-aged type 1 diabetics who had been treated with insulin for some decades? Importantly there has never been a major multi-million $ trial of the effects of a low-fat high-carbohydrate diet on the development of atherosclerosis in otherwise health individuals. But there has been one such trial on weight loss and cardiovascular outcomes in diabetic patients - The LookAhead trial. The study was terminated after 9.5 years because it was considered "futile" to continue as there was no evidence that the diet produced any protection from coronary heart disease. The point is that if you have diabetes, you're probably not best advised to adopt either a fat-substitution diet or a low-fat high-carbohydrate diet, since neither is likely to produce any health benefits and both could be harmful. @BenBikmanPhD @zoeharcombe @bigfatsurprise @AKoutnik @LoreofRunning1 @sweatscience @drericwestman @markkaplan20
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The ketogenic diet as a treatment for mental health conditions is getting even more attention from researchers, clinicians, and mainstream media!
New Scientist
@newscientistApr 27
You may think of the high-fat, low-carb eating plan as a faddish way to lose weight. But the keto diet is now being used to tackle conditions from severe depression to bipolar disorder and anorexia, with transformative results newscientist.com/article/252…
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gary taubes retweeted
Well, well, what do we have here? A study on carbohydrate fuelling before and during exercise is judged the 2025 research article with the best impact in the "elite" journal, the American Journal of Physiology, Cell Physiology. Now, why would the Editors choose, from amongst all the submissions to a world-leading journal publishing work on key advances in cellular biology, a publication from a usually peripheral (ie minor) discipline like sports science/sports nutrition for this prestigious award? Perhaps because we have shown, for the first time, the consequences of the existence of two separately-regulated glucose pools - the large and glucose pools - with different effects on human exercise performance. Hopefully this recognition of the meaning of this paradigm shift for the understanding of glucose regulation in the human body, might slowly percolate into the discussion of how carbohydrates influence human exercise performance. More science, less wrath (perhaps) @PhilipPrins11 @akoutnik @PaulBLaursen @sweatscience @theplews1 @DrPhilMaffetone @TheNoakesF @Brady_H @drjamesdinic @zbitter @garytaubes @zoeharcombe @bigfatsurprise @LoreofRunning1 @lowcarbGP
🚨 Boston Marathon carb fueling debates are raging: extremely high-carb intake? … or can minimal carb intake work? Incredibly honored that our RCT on athlete fueling won @APSPhysiology 2025 BEST IMPACT PAPER (@AJPCellPhys) 🏆 We tested key scientific questions in Ironman-level athletes: 1️⃣ Does LCHF impair strenuous time-to-exhaustion performance? 2️⃣ Does just 10g/hr carbs (3.4g/20min — 6-12x below guidelines) improve performance? How? 3️⃣ What’s the keto-adaptation homeostasis timeline? 📜 Full article: journals.physiology.org/doi/… None of this happens without the incredible teamwork from @PhilipPrins11, @ProfTimNoakes, @DominicDAgosti2 & the whole crew who worked hard to push the evidence forward on how athletes should fuel.
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